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Biological Weapons Defense pp 155–184Cite as

Medical Protection Against Brucellosis

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Part of the book series: Infectious Disease ((ID))

Abstract

Human brucellosis is a systemic, febrile illness caused by at least five different species of Brucella, a Gram-negative, aerobic, nonmotile, nonspore-forming coccobacillus. It has long been considered a prime biowarfare threat agent. As an intracellular parasite of mononuclear phagocytes, it successfully evades many host immune responses and resists easy eradication by antimicrobial agents. These characteristics both increase the need for effective strategies to protect against infection and create challenges to development of vaccines and other antimicrobial countermeasures against the organism.

The views of the authors do not purport to reflect the position of the Department of the Army or the Department of Defense (para 4-3, AR 360-5). Data discussed from unpublished manuscripts was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition.

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Authors and Affiliations

  1. Department of Bacterial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD

    David L. Hoover MD & Richard H. Borschel PhD

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  1. David L. Hoover MD
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  2. Richard H. Borschel PhD
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Editors and Affiliations

  1. Department of Homeland Security, Science and Technology Directorate, National Biodefense Analysis and Countermeasures Center, Fort Detrick, MD

    Luther E. Lindler PhD  & George W. Korch PhD (Deputy Director) &  (Deputy Director)

  2. Department of Bacterial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD

    Luther E. Lindler PhD

  3. Department of Cell Biology and Biochemistry, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD

    Frank J. Lebeda PhD

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Hoover, D.L., Borschel, R.H. (2005). Medical Protection Against Brucellosis. In: Lindler, L.E., Lebeda, F.J., Korch, G.W. (eds) Biological Weapons Defense. Infectious Disease. Humana Press. https://doi.org/10.1385/1-59259-764-5:155

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