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Ocular Consequences and Late Effects of Brain Tumor Treatments

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Late Effects of Treatment for Brain Tumors

Part of the book series: Cancer Treatment and Research ((CTAR,volume 150))

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References

  1. Punt J. Cinical syndromes In: Walker D, Periolongo G, Punt J, Taylor R, eds. Brain and Spinal Tumors of Childhood. London: Arnold; 2004:99–106.

    Google Scholar 

  2. Schwartz C HW, Constine L. Survivors of Childhood Cancer: Assessment and Management. St. Louis, Mo: Mosby; 1994.

    Google Scholar 

  3. Friedman DL CL. Late Effects on Cancer Treatment. Fourth Edition: Lippincott Williams and Wilkins; 2005.

    Google Scholar 

  4. Lessell S. Friendly fire: neurogenic visual loss from radiation therapy. J Neuroophthalmol. 2004;24:243–250.

    Article  PubMed  Google Scholar 

  5. Fishman ML, Bean SC, Cogan DG. Optic atrophy following prophylactic chemotherapy and cranial radiation for acute lymphocytic leukemia. Am J Ophthalmol. 1976;82:571–6.

    PubMed  CAS  Google Scholar 

  6. Barabino S, Raghavan A, Loeffler J, et al. Radiotherapy-induced ocular surface disease. Cornea. 2005;24:909–914.

    Article  PubMed  Google Scholar 

  7. Durkin SR, Roos D, Higgs B, et al. Ophthalmic and adnexal complications of radiotherapy. Acta Ophthalmol Scand. 2007;85:240–250.

    Article  PubMed  Google Scholar 

  8. Brady LW, Shields J, Augusburger J, et al. Complications from radiation therapy to the eye. Front Radiat Ther Oncol. 1989;23:238–250; discussion 51–4.

    PubMed  CAS  Google Scholar 

  9. Riekki R, Jukkola A, Oikarinen A, et al. Radiation therapy induces tenascin expression and angiogenesis in human skin. Acta Derm Venereol. 2001;81:329–333.

    Article  PubMed  CAS  Google Scholar 

  10. Pilapil F, Studva KV, Dietz KA. Programmed instruction: cancer care. Radiation therapy: external radiation. Cancer Nurs. 1979;2:129–138.

    PubMed  CAS  Google Scholar 

  11. Roth J, Brown N, Catterall M, et al. Effects of fast neutrons on the eye. Br J Ophthalmol. 1976;60:236–244.

    Article  PubMed  CAS  Google Scholar 

  12. Karp LA, Streeten BW, Cogan DG. Radiation-induced atrophy of the Meibomian gland. Arch Ophthalmol. 1979;97:303–305.

    Article  PubMed  CAS  Google Scholar 

  13. Bessell EM, Henk JM, Whitelocke RA, et al. Ocular morbidity after radiotherapy of orbital and conjunctival lymphoma. Eye. 1987;1(Pt 1):90–96.

    Article  PubMed  Google Scholar 

  14. Kennerdell JS, Flores NE, Hartsock RJ. Low-dose radiotherapy for lymphoid lesions of the orbit and ocular adnexa. Ophthal Plast Reconstr Surg. 1999;15:129–133.

    Article  PubMed  CAS  Google Scholar 

  15. Parsons JT, Bova FJ, Fitzgerald CR, et al. Severe dry-eye syndrome following external beam irradiation. Int J Radiat Oncol Biol Phys. 1994;30:775–780.

    PubMed  CAS  Google Scholar 

  16. Stafford SL, Kozelsky TF, Garrity JA, et al. Orbital lymphoma: radiotherapy outcome and complications. Radiother Oncol. 2001;59:139–144.

    Article  PubMed  CAS  Google Scholar 

  17. Parsons JT, Fitzgerald CR, Hood CI, et al. The effects of irradiation on the eye and optic nerve. Int J Radiat Oncol Biol Phys. 1983;9:609–622.

    Article  PubMed  CAS  Google Scholar 

  18. Parsons JT, Bova FJ, Mendenhall WM, et al. Response of the normal eye to high dose radiotherapy. Oncology (Williston Park). 1996;10:837–847; discussion 47–8, 51–52.

    CAS  Google Scholar 

  19. Kwok SK, Ho PC, Leung SF, et al. An analysis of the incidence and risk factors of developing severe keratopathy in eyes after megavoltage external beam irradiation. Ophthalmology. 1998;105:2051–2055.

    Article  PubMed  CAS  Google Scholar 

  20. Weber DC, Chan AW, Lessell S, et al. Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons/protons. Radiother Oncol. 2006;81:243–249.

    Article  PubMed  Google Scholar 

  21. Nakissa N, Rubin P, Strohl R, et al. Ocular and orbital complications following radiation therapy of paranasal sinus malignancies and review of literature. Cancer. 1983;51:980–986.

    Article  PubMed  CAS  Google Scholar 

  22. Buatois F, Coquard R, Pica A, et al. [Treatment of eyelid carcinomas of 2 cmm or less by contact radiotherapy]. J Fr Ophtalmol. 1996;19:405–409.

    PubMed  CAS  Google Scholar 

  23. Eiseman AS, Flanagan JC, Brooks AB, et al. Ocular surface, ocular adnexal, and lacrimal complications associated with the use of systemic 5-fluorouracil. Ophthal Plast Reconstr Surg. 2003;19:216–224.

    Article  PubMed  Google Scholar 

  24. Esmaeli B, Hidaji L, Adinin RB, et al. Blockage of the lacrimal drainage apparatus as a side effect of docetaxel therapy. Cancer. 2003;98:504–507.

    Article  PubMed  CAS  Google Scholar 

  25. Sanders JE. Chronic graft-versus-host disease and late effects after hematopoietic stem cell transplantation. Int J Hematol. 2002;76(Suppl 2):15–28.

    Article  PubMed  Google Scholar 

  26. Ahmad SM, Stegman Z, Fructhman S, et al. Successful treatment of acute ocular graft-versus-host disease with tacrolimus (FK506). Cornea. 2002;21:432–433.

    Article  PubMed  Google Scholar 

  27. Kiang E, Tesavibul N, Yee R, et al. The use of topical cyclosporin A in ocular graft-versus-host-disease. Bone Marrow Transplant. 1998;22:147–151.

    Article  PubMed  CAS  Google Scholar 

  28. Murphy PT, Sivakumaran M, Fahy G, et al. Successful use of topical retinoic acid in severe dry eye due to chronic graft-versus-host disease. Bone Marrow Transplant. 1996;18:641–642.

    PubMed  CAS  Google Scholar 

  29. Ogawa Y, Okamoto S, Mori T, et al. Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplant. 2003;31:579–583.

    Article  PubMed  CAS  Google Scholar 

  30. Robinson MR, Lee SS, Rubin BI, et al. Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant. 2004;33:1031–1035.

    Article  PubMed  CAS  Google Scholar 

  31. Rocha V, Wagner JE, Jr., Sobocinski KA, et al. Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and international bone marrow transplant registry working committee on alternative donor and stem cell sources. N Engl J Med. 2000;342:1846–1854.

    Article  PubMed  CAS  Google Scholar 

  32. Shields CL, Naseripour M, Shields JA, et al. Custom-designed plaque radiotherapy for nonresectable iris melanoma in 38 patients: tumor control and ocular complications. Am J Ophthalmol. 2003;135:648–656.

    Article  PubMed  Google Scholar 

  33. Shields CL, Shields JA, Cater J, et al. Plaque radiotherapy for retinoblastoma: long-term tumor control and treatment complications in 208 tumors. Ophthalmology. 2001;108:2116–2121.

    Article  PubMed  CAS  Google Scholar 

  34. Morita K, Kawabe Y. Late effects on the eye of conformation radiotherapy for carcinoma of the paranasal sinuses and nasal cavity. Radiology. 1979;130:227–232.

    PubMed  CAS  Google Scholar 

  35. Jabs DA, Wingard J, Green WR, et al. The eye in bone marrow transplantation. III. Conjunctival graft-vs-host disease. Arch Ophthalmol. 1989;107:1343–1348.

    Article  PubMed  CAS  Google Scholar 

  36. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant. 1995;15:825–828.

    PubMed  CAS  Google Scholar 

  37. Saito T, Shinagawa K, Takenaka K, et al. Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. Int J Hematol. 2002;75:332–334.

    Article  PubMed  Google Scholar 

  38. Bacin F, Kwiatkowski F, Dalens H, et al. [Long-term results of cobalt 60 curietherapy for uveal melanoma]. J Fr Ophtalmol. 1998;21:333–344.

    PubMed  CAS  Google Scholar 

  39. Worgul BV, Merriam GR, Szechter A, et al. Lens epithelium and radiation cataract. I. Preliminary studies. Arch Ophthalmol. 1976;94:996–999.

    Article  PubMed  CAS  Google Scholar 

  40. Worgul BV, Rothstein H. On the mechanism of thyroid mediated mitogenesis in adult anura. I. Preliminary analysis of growth kinetics and macromolecular syntheses, in lens epithelium, under the influence of exogenous triiodothyronine. Cell Tissue Kinet. 1974;7:415–424.

    PubMed  CAS  Google Scholar 

  41. Paulino AC. Role of radiation therapy in parameningeal rhabdomyosarcoma. Cancer Invest. 1999;17:223–230.

    Article  PubMed  CAS  Google Scholar 

  42. Alter AJ, Leinfelder PJ. Roentgen-ray cataract; effects of shielding of the lens and ciliary body. AMA Arch Ophthalmol. 1953;49:257–260.

    Article  PubMed  CAS  Google Scholar 

  43. Macfaul PA, Bedford MA. Ocular complications after therapeutic irradiation. Br J Ophthalmol. 1970;54: 237–247.

    Article  PubMed  CAS  Google Scholar 

  44. Livingston PM, Carson CA, Taylor HR. The epidemiology of cataract: a review of the literature. Ophthal Epidemiol. 1995;2:151–164.

    Article  CAS  Google Scholar 

  45. West SK, Valmadrid CT. Epidemiology of risk factors for age-related cataract. Sur Ophthalmol. 1995;39:323–334.

    Article  CAS  Google Scholar 

  46. Dai E, et al. In: Yanoff M, Duker JS eds. Ophthalmology. C. V. Mosby. 2nd edition.

    Google Scholar 

  47. Anteby I, Ramu N, Gradstein L, et al. Ocular and orbital complications following the treatment of retinoblastoma. Eur J Ophthalmol. 1998;8:106–111.

    PubMed  CAS  Google Scholar 

  48. Takeda A, Shigematsu N, Suzuki S, et al. Late retinal complications of radiation therapy for nasal and paranasal malignancies: relationship between irradiated-dose area and severity. Int J Radiat Oncol Biol Phys. 1999;44:599–605.

    Article  PubMed  CAS  Google Scholar 

  49. Wilde G, Sjostrand J. A clinical study of radiation cataract formation in adult life following gamma irradiation of the lens in early childhood. Br J Ophthalmol. 1997;81:261–266.

    Article  PubMed  CAS  Google Scholar 

  50. Schipper J, Tan KE, van Peperzeel HA. Treatment of retinoblastoma by precision megavoltage radiation therapy. Radiother Oncol. 1985;3:117–132.

    Article  PubMed  CAS  Google Scholar 

  51. Deeg HJ, Flournoy N, Sullivan KM, et al. Cataracts after total body irradiation and marrow transplantation: a sparing effect of dose fractionation. Int J Radiat Oncol Biol Phys. 1984;10:957–964.

    Article  PubMed  CAS  Google Scholar 

  52. Group COMS. Incidence of cataract and outcomes after cataract surgery in the first 5 years afetr iodine 125 bracgytherapy in the Collaborative Ocular Melanoma Study: COMS Report No. 27. Ophthalmology. 2007;114(7):1363–1371.

    Article  Google Scholar 

  53. Belkacemi Y, Labopin M, Vernant JP, et al. Cataracts after total body irradiation and bone marrow transplantation in patients with acute leukemia in complete remission: a study of the European Group for Blood and Marrow Transplantation. Int J Radiat Oncol Biol Phys. 1998;41:659–668.

    Article  PubMed  CAS  Google Scholar 

  54. Belkacemi Y, Ozsahin M, Pene F, et al. Cataractogenesis after total body irradiation. Int J Radiat Oncol Biol Phys. 1996;35:53–60.

    Article  PubMed  CAS  Google Scholar 

  55. Zierhut D, Lohr F, Schraube P, et al. Cataract incidence after total-body irradiation. Int J Radiat Oncol Biol Phys. 2000;46:131–135.

    Article  PubMed  CAS  Google Scholar 

  56. Beyzadeoglu M, Dirican B, Oysul K, et al. Evaluation of fractionated total body irradiation and dose rate on cataractogenesis in bone marrow transplantation. Haematologia (Budap). 2002;32:25–30.

    Article  PubMed  Google Scholar 

  57. Parsons JT, Bova FJ, Fitzgerald CR, et al. Radiation retinopathy after external-beam irradiation: analysis of time-dose factors. Int J Radiat Oncol Biol Phys. 1994;30:765–773.

    PubMed  CAS  Google Scholar 

  58. Gupta A, Dhawahir-Scala F, Smith A, et al. Radiation retinopathy: case report and review. BMC Ophthalmol. 2007;7:6.

    Article  PubMed  Google Scholar 

  59. Subramanian PS, Bressler NM, Miller NR. Radiation retinopathy after fractionated stereotactic radiotherapy for optic nerve sheath meningioma. Ophthalmology. 2004;111:565–567.

    Article  PubMed  Google Scholar 

  60. Monroe AT, Bhandare N, Morris CG, et al. Preventing radiation retinopathy with hyperfractionation. Int J Radiat Oncol Biol Phys. 2005;61:856–864.

    Article  PubMed  Google Scholar 

  61. Zamber RW, Kinyoun JL. Radiation retinopathy. West J Med. 1992;157:530–533.

    PubMed  CAS  Google Scholar 

  62. Brown GC, Shields JA, Sanborn G, et al. Radiation retinopathy. Ophthalmology. 1982;89:1494–1501.

    PubMed  CAS  Google Scholar 

  63. Anderson NG, Regillo C. Ocular manifestations of graft versus host disease. Curr Opin Ophthalmol. 2004;15:503–507.

    Article  PubMed  Google Scholar 

  64. Shukovsky LJ, Fletcher GH. Retinal and optic nerve complications in a high dose irradiation technique of ethmoid sinus and nasal cavity. Radiology. 1972;104:629–634.

    PubMed  CAS  Google Scholar 

  65. Kim RY, Anderlini P, Naderi AA, et al. Scleritis as the initial clinical manifestation of graft-versus-host disease after allogenic bone marrow transplantation. Am J Ophthalmol. 2002;133:843–845.

    Article  PubMed  Google Scholar 

  66. Alvarez MT, Hernaez JM, Ciancas E, et al. Multifocal choroiditis after allogenic bone marrow transplantation. Eur J Ophthalmol. 2002;12:135–137.

    PubMed  CAS  Google Scholar 

  67. Hykin PG, Shields CL, Shields JA, et al. The efficacy of focal laser therapy in radiation-induced macular edema. Ophthalmology. 1998;105:1425–1429.

    Article  PubMed  CAS  Google Scholar 

  68. Shields CL, Demirci H, Dai V, et al. Intravitreal triamcinolone acetonide for radiation maculopathy after plaque radiotherapy for choroidal melanoma. Retina. 2005;25:868–874.

    Article  PubMed  Google Scholar 

  69. Sutter FK, Gillies MC. Intravitreal triamcinolone for radiation-induced macular edema. Arch Ophthalmol. 2003;121:1491–1493.

    Article  PubMed  Google Scholar 

  70. Finger PT, Chin K. Anti-vascular endothelial growth factor bevacizumab (avastin) for radiation retinopathy. Arch Ophthalmol. 2007;125:751–756.

    Article  PubMed  CAS  Google Scholar 

  71. Solano JM, Bakri SJ, Pulido JS. Regression of radiation-induced macular edema after systemic bevacizumab. Can J Ophthalmol. 2007;42:748–749.

    Article  PubMed  Google Scholar 

  72. Boschetti M, De Lucchi M, Giusti M, et al. Partial visual recovery from radiation-induced optic neuropathy after hyperbaric oxygen therapy in a patient with Cushing disease. Eur J Endocrinol. 2006;154:813–818.

    Article  PubMed  CAS  Google Scholar 

  73. Parsons JT, Bova FJ, Fitzgerald CR, et al. Radiation optic neuropathy after megavoltage external-beam irradiation: analysis of time-dose factors. Int J Radiat Oncol Biol Phys. 1994;30:755–763.

    PubMed  CAS  Google Scholar 

  74. Hopewell JW, van der Kogel AJ. Pathophysiological mechanisms leading to the development of late radiation-induced damage to the central nervous system. Front Radiat Ther Oncol. 1999;33:265–275.

    Article  PubMed  CAS  Google Scholar 

  75. Guy J, Schatz NJ. Hyperbaric oxygen in the treatment of radiation-induced optic neuropathy. Ophthalmology. 1986;93:1083–1088.

    PubMed  CAS  Google Scholar 

  76. Miller NR. Radiation-induced optic neuropathy: still no treatment. Clin Experiment Ophthalmol. 2004;32:233–235.

    Article  PubMed  Google Scholar 

  77. Levy RL, Miller NR. Hyperbaric oxygen therapy for radiation-induced optic neuropathy. Ann Acad Med Singapore. 2006;35:151–157.

    PubMed  Google Scholar 

  78. Finger PT. Anti-VEGF bevacizumab (Avastin) for radiation optic neuropathy. Am J Ophthalmol 2007;143:335–338.

    Article  PubMed  CAS  Google Scholar 

  79. Landier W, Bhatia S, Eshelman DA, et al. Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing Discipline. J Clin Oncol. 2004;22:4979–4990.

    Article  PubMed  Google Scholar 

  80. Mohammadpour M, Javadi MA. Keratitis associated with multiple endocrine deficiency. Cornea. 2006;25:112–114.

    Article  PubMed  Google Scholar 

  81. Franklin RM, Kenyon KR, Tutschka PJ, et al. Ocular manifestations of graft-vs-host disease. Ophthalmology. 1983;90:4–13.

    PubMed  CAS  Google Scholar 

  82. Cheng LL, Kwok AK, Wat NM, et al. Graft-vs-host-disease-associated conjunctival chemosis and central serous chorioretinopathy after bone marrow transplant. Am J Ophthalmol. 2002;134:293–295.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. San Jorge Children’s Hospital, Division of Hematology/Oncology and Stem Cell Transplant, San Juan, PR, USA

    María E. Echevarría MD

  2. Division of Hematology, Oncology and Stem Cell Transplantation, Children’s Memorial Hospital, Chicago, IL, USA

    Joanna L. Weinstein MD

Authors
  1. María E. Echevarría MD
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  2. Joanna L. Weinstein MD
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Correspondence to María E. Echevarría MD .

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Editors and Affiliations

  1. Dept. Pediatrics, Children's Memorial Hospital, Children's Plaza 2300, Chicago, 30614, U.S.A.

    Stewart Goldman

  2. Dana-Farber Cancer Institute, Harvard Medical School, Binney St. 44, Boston, 02115, U.S.A.

    Christopher D. Turner

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Echevarría, M.E., Weinstein, J.L. (2009). Ocular Consequences and Late Effects of Brain Tumor Treatments. In: Goldman, S., Turner, C. (eds) Late Effects of Treatment for Brain Tumors. Cancer Treatment and Research, vol 150. Springer, Boston, MA. https://doi.org/10.1007/b109924_12

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