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Apoptosis pp 167–184Cite as

Apoptosis and bioprocess technology

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Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 62))

Abstract

Optimisation of the production of biopharmaceuticals in animal cell lines has become a key area of research. The identification of apoptosis as the major mechanism of cell death during such processes has raised the importance of studies of cell death when implementing culture optimisation strategies. In this article we present an overview of the studies which have demonstrated the induction of apoptosis during the cultivation of industrially important animal cell lines. We also discuss studies which have shown that deprivation of factors such as amino acids, glucose, serum and oxygen are potent inducers of apoptosis in industrial cultures. The suppression of apoptosis under these conditions has been demonstrated by a number of recent reports, and we describe ways in which this knowledge may be applied in the development of novel solutions to some of the technical problems associated with the development of successful large scale culture process. The article concludes with a discussion of future directions for apoptosis research in bioprocess technology.

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Authors and Affiliations

  1. Centre for Bioprocess Engineering, School of Chemical Engineering, University of Birmingham Edgbaston, B15 2TT, UK, Birmingham

    R. P. Singh & M. Al-Rubeai

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  1. R. P. Singh
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  2. M. Al-Rubeai
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M. Al-Rubeai (Volume Editor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Singh, R.P., Al-Rubeai, M. (1998). Apoptosis and bioprocess technology. In: Al-Rubeai, M. (eds) Apoptosis. Advances in Biochemical Engineering/Biotechnology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0102310

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  • DOI: https://doi.org/10.1007/BFb0102310

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  • Print ISBN: 978-3-540-64153-7

  • Online ISBN: 978-3-540-69694-0

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