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The role of caspases in apoptosis

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Book cover Apoptosis

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 62))

Abstract

The process of apoptosis, or programmed cell death, is fundamental during normal development and homeostasis and aberrant apoptosis has been implicated in a number of human diseases. The cellular machinery involved in the execution of apoptosis includes a family of cysteine proteases termed caspases. Caspases exhibit the rare substrate preference of cleavage C-terminal to aspartate residues, a property shared only by the cytotoxic lymphocyte serine protease, granzyme B. Experimental evidence demonstrates a vital role for caspase activation in the apoptotic pathway, and, as such, caspases are a target for the development of agents that can modulate their activity. This article reviews the members of the caspase family and the role that each contributes to the execution of cell death induced by apoptotic stimuli.

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Abbreviations

ICE:

interleukin-1β-converting enzyme

PARP:

poly(ADP-ribose)-polymerase

TNF:

tumour necrosis factor

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  1. The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Rundle Mall, PO Box 14, 5000, Adelaide, South Australia

    Natasha L. Harvey

  2. The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Rundle Mall, PO Box 14, 5000, Adelaide, South Australia

    Sharad Kumar

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  1. Natasha L. Harvey
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  2. Sharad Kumar
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M. Al-Rubeai (Volume Editor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Harvey, N.L., Kumar, S. (1998). The role of caspases in apoptosis. In: Al-Rubeai, M. (eds) Apoptosis. Advances in Biochemical Engineering/Biotechnology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0102307

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  • DOI: https://doi.org/10.1007/BFb0102307

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64153-7

  • Online ISBN: 978-3-540-69694-0

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