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NHC-Catalyzed Cyclocondensation of α,β-Unsaturated Carboxylic Acids

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New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations

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Abstract

Catalytic enantioselective reactions employing α,β-unsaturated acyl azolium intermediate have attracted great attention and have been intensively explored in these years. A variety of α,β-unsaturated carbonyl compounds have been developed for these reactions (Fig. 4.1). In this area, the α,β-unsaturated acyl azolium is usually generated from ynals, enals, α-bromoenals, α,β-unsaturated acyl fluorides and esters by (oxidative) N-heterocyclic carbene (NHC) catalysis.

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Authors and Affiliations

  1. Institute of Chemistry, Chinese Academy of Sciences, Beijing, China

    Dr. Xiangyu Chen

  2. Institute of Organic Chemistry, RWTH Aachen University, Aachen, Germany

    Dr. Xiangyu Chen

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  1. Dr. Xiangyu Chen
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Correspondence to Xiangyu Chen .

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Chen, X. (2017). NHC-Catalyzed Cyclocondensation of α,β-Unsaturated Carboxylic Acids. In: New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-10-2899-1_4

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