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Nanoscience Advances in CBRN Agents Detection, Information and Energy Security pp 423–436Cite as

Nanoparticles Containing a Copper Chelator: A Possible Instrument for Radiation Protection

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Abstract

Nanotechnology is considered as an emerging technology with great potential in a wide range of applications. In addition to various industrial uses, several innovations are foreseen in biotechnology, medicine and medical technology. The application of nanotechnology to medicine also provides an innovative approach that can enhance the effectiveness of radiotherapies or radioprotection. The aim of the present study was to investigate the radioprotective effect of neocuproine-nanodiamond nanoparticles on gamma irradiated human hepatocellular carcinoma cells. We revealed a significant increase in the radioprotection efficacy against gamma irradiation of HepG2 cells pre-exposed to nanodiamonds or nanodiamonds-neocuproine nanoparticles. The results showed that the protective effect of nanoparticles is connected with decreasing free radicals released during the irradiation and with cytokinesis-blocked micronucleous formation, does protecting cells from cyto- and genotoxic effect of gamma irradiation.

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Author information

Authors and Affiliations

  1. Medical and Biological Research Laboratory, “Roumen Tsanev” Institute of Molecular Biology – Bulgarian Academy of Sciences, Sofia, Bulgaria

    V. V. Vasilieva & M. D. Apostolova

  2. Department of Radiation Protection, Military Medical Academy, Sofia, Bulgaria

    V. V. Vasilieva & M. Alyakov

Authors
  1. V. V. Vasilieva
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  2. M. Alyakov
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  3. M. D. Apostolova
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Corresponding author

Correspondence to M. D. Apostolova .

Editor information

Editors and Affiliations

  1. Department of Physics, University of Chemical Technology and Metallurgy, Sofia, Bulgaria

    Plamen Petkov

  2. Department of Physics, Technical University of Moldova, Chisinau, Moldova

    Dumitru Tsiulyanu

  3. Dept. of Mathematics and Natural Sciences, University of Kassel, Kassel, Germany

    Wilhelm Kulisch

  4. Inst. of Nanostructure Technologies and Analytics, University of Kassel, Kassel, Germany

    Cyril Popov

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Vasilieva, V.V., Alyakov, M., Apostolova, M.D. (2015). Nanoparticles Containing a Copper Chelator: A Possible Instrument for Radiation Protection. In: Petkov, P., Tsiulyanu, D., Kulisch, W., Popov, C. (eds) Nanoscience Advances in CBRN Agents Detection, Information and Energy Security. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9697-2_43

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