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Suppression of Differentiation and Maturation of Dendritic Cells: Stem Cells from Different Sources Vary in Their Effect

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Book cover Stem Cells and Cancer Stem Cells, Volume 12

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 12))

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Abstract

Mesenchymal stem cells (MSC) are multipotent progenitor cells with the ability to modulate and suppress immune responses in vitro and in vivo. One of their immunoregulatory properties is the suppression of dendritic cell (DC) differentiation, maturation and effector functions thus indirectly affecting T-cell priming and polarization. It has been shown that MSC from different sources and species exert varying immunoregulatory effects on DC in vitro. These findings demonstrate that careful consideration should be taken when choosing a source of MSC for cellular therapy.

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Authors and Affiliations

  1. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, Austria

    Barbara Kronsteiner & Susanne Wolbank

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  1. Barbara Kronsteiner
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  2. Susanne Wolbank
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Correspondence to Barbara Kronsteiner .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Kronsteiner, B., Wolbank, S. (2014). Suppression of Differentiation and Maturation of Dendritic Cells: Stem Cells from Different Sources Vary in Their Effect. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 12. Stem Cells and Cancer Stem Cells, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8032-2_8

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