Methods of Studying Human Chromosomes and Nomenclature. The Normal Human Karyotype
Ever since the elucidation of the correct human chromosome number (2n = 46) by Tijo and Levan , clinical cytogenetics has become an important branch of medical genetics. It was natural that this epoch-making discovery was soon followed by discovery of various numerical chromosomal abnormalities such as trisomy 21 , trisomy 13 , trisomy 18  and sex chromosome abnormalities that included monosomy X , XXY  and XXX . Several of these important observations were followed by breakthroughs in the technological aspects of cell cultures, which had been a stumbling block in routinely studying human chromosomes. Two independent investigators, Nowell  and Moorehead et al. , described a simple method of cell culture to study human chromosomes, thus paving the way for the clinical cytogenetics revolution.
- Methods of Studying Human Chromosomes and Nomenclature. The Normal Human Karyotype
- Book Title
- Atlas of Human Chromosome Heteromorphisms
- Book Part
- Part I
- pp 11-31
- Print ISBN
- Online ISBN
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media B.V.
- Additional Links
- Industry Sectors
- eBook Packages
To view the rest of this content please follow the download PDF link above.