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Renal Anemia pp 107–113Cite as

Is secondary hyperparathyroidism a significant cause of renal anemia?

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Abstract

Anemia, a major feature of end-stage renal disease (ESRD) is chiefly due to diminished erythropoietin synthesis by diseased kidneys [1]. It is suggested that parathyroid hormone, when in excessive amounts, interferes with normal erythropoiesis by down regulating the erythropoietin receptors on erythroid progenitor cells in the bone marrow [2]. Therefore, physiologic concentrations of erythropoietin can no longer sustain normal red cell counts, so normocytic and normochromic anemia ensues [2]. In primary hyperparathyroidism, this effect is observed with very high concentrations of parathyroid hormone. In secondary hyperparathyroidism during chronic renal failure, this effect is more pronounced because erythropoietin synthesis is impaired [2].

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Authors
  1. Onyekachi Ifudu
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Editors and Affiliations

  1. Inpatient Dialysis Services, SUNY Downstate Medical Center, Brooklyn, New York, USA

    Onyekachi Ifudu (Associate Professor of Medicine, Director) (Associate Professor of Medicine, Director)

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© 2002 Springer Science+Business Media Dordrecht

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Ifudu, O. (2002). Is secondary hyperparathyroidism a significant cause of renal anemia?. In: Ifudu, O. (eds) Renal Anemia. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9998-6_11

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  • DOI: https://doi.org/10.1007/978-94-015-9998-6_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6045-7

  • Online ISBN: 978-94-015-9998-6

  • eBook Packages: Springer Book Archive

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