Abstract
At one time, the term, ‘basal ganglia’ was used to describe all the large nuclear masses in the interior of the brain, including the thalamus. Gradually, its use has become restricted to five closely related nuclei: caudate, putamen, globus pallidus, subthalamic nucleus and substantia nigra (Figure 11.1). The basal ganglia receive no direct sensory inputs and, like the cerebellum, send no direct motor output to the spinal cord. However, there is no doubt that these structures are involved in the control of movement. All diseases of the basal ganglia in man have some disorder of movement as their primary symptom. These range from an excess of involuntary movements (for instance, chorea) to a poverty and slowness of voluntary movement (for instance, Parkinson’s disease). Important as their role may be, there is to date no agreement on the precise function or the mechanism of action of the basal ganglia.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Bibliography
Review articles and books
Crossman, A. R. and Sambrook, M. A. (1989) Neural mechanisms in disorders of movement, John Libbey, London.
Ciba Foundation (1984) Functions of the basal ganglia, Ciba Foundation Symposium, 107, Pitman, London.
Marsden, C. D. (1982) The mysterious motor function of the basal ganglia, Neurology, 32, 514–539.
Trends in Neuroscience (1990), volume 13, no. 10. Special edition on the basal ganglia.
Original papers
Albin, R. L., Young, A. B. and Penney, J. B. (1989) The functional anatomy of basal ganglia disorders, Trends Neurosci., 12, 366–375.
Albin, R. L., Reiner, A., Anderson, K. D. et al. (1992) Preferential loss of striato-external pallidal projection neurones in presymptomatic Huntington’s disease, Ann. Neurol., 31, 425–430.
Alexander, G. E., DeLong, M. R. and Strick, P. L. (1986) Parallel organisation of functionally segregated circuits linking basal ganglia and cortex, Annu. Rev. Neurosci., 9, 357–381.
Alexander, G. E. and Crutcher, M. D. (1990a) Functional architecture of basal ganglia circuits: neural substrates of parallel processing, Trends Neurosci., 13, 266–271.
Alexander, G. E. and Crutcher, M. D. (1990b) Preparation for movement: neural representations of intended direction in three motor areas of the monkey, J. Neurophysiol., 64, 133–150; 150-163; 164-178.
Anderson, M. E. and Horak, F. B. (1985) Influence of the globus pallidus on arm movement in monkeys, Parts 1, 2, and 3, J. Neurophysiol., 52, 290–304; 305-322; 54, 433-448.
Anderson, M. E. and Turner, R. S. (1991) A quantitative analysis of pallidal discharge during targeted reaching movement in the monkey, Exp. Brain Res., 86, 623–632.
Benecke, R., Rothwell, J. C., Dick, J. P. R. et al. (1986) Performance of simultaneous movements in patients with Parkinson’s disease, Brain 109, 739–757.
Benecke, R., Rothwell, J. C, Dick, J. P. R. et al. (1987) Disturbance of sequential movements in patients with Parkinson’s disease, Brain, 110, 361–379.
Bergman, H., Wichmann, T. and DeLong, M. R. (1990) Reversal of experimental parkinsonism by lesions of the subthalamic nucleus, Science, 249, 1436–1438.
Brotchie, P., Ianseck, R. and Home, M. K. (1991) Motor function of the monkey globus pallidus, Papers 1 and 2, Brain, 114, 1667–1702.
Carpenter, M. B. (1981) Anatomy of the corpus striatum and brainstem integrating systems, in V. B. Brooks (ed.), Handbook of Physiology, sect. 1, vol. 2, part 2, Williams and Wilkins, Baltimore, pp. 947–995.
Chevalier, G. and Deniau, J. M. (1990) Disinhibition as a basic process in the expression of striatal function, Trends Neurosci. 13, 277–280.
Crutcher, M. D. and DeLong, M. R. (1984) Single cell studies of the primate putamen, Parts 1 and 2, Exp. Brain Res., 53, 233–258.
Day, B. L., Dick, J. P. R. and Marsden, C. D. (1984) Patients with Parkinson’s disease can employ a predictive motor strategy, J. Neurol. Neurosurg. Psychiatr., 47, 1299–1306.
DeLong, M. R. and Georgopoulos, A. P. (1979) Motor function of basal ganglia as revealed by studies of single cell activity in the behaving primate, Adv. Neurol., 24, 131–140.
DeLong, M. R. and Georgopoulos, A. P. (1981) Motor functions of the basal ganglia, in V. B. Brooks (ed.), Handbook of Physiology, sect. 1, vol. 2, part 2, Williams and Wilkins, Baltimore, pp. 1017–1061.
DeLong, M. R., Crutcher, M. D. and Georgopoulos, A. P. (1985) Primate globus pallidus and subthalamic nucleus: functional organisation, J. Neurophysiol., 53, 530–543.
Dick, J. P. R., Rothwell, J. C, Day, B. L. et al. (1989) The Bereitschaftspotential is abnormal in Parkinson’s disease, Brain, 112, 233–244.
Evarts, E. V., Teravainen, N. H. and Calne, D. B. (1981) Reaction time in Parkinson’s disease, Brain, 104, 167–186.
Filion, M. and Tremblay, L. (1991) Abnormal spontaneous activity of globus pallidus neurones in monkeys with MPTP induced parkinsonism, Brain Res., 547, 142–151; 152-161.
Flowers, K. A. (1976) Visual ‘closed loop’ and ‘open loop’ characteristics of voluntary movement in patients with parkinsonism and intention tremor, Brain, 99, 269–310.
Flowers, K. A. (1978) Lack of prediction in the motor behaviour of parkinsonism, Brain, 101, 35–52.
Graybiel, A. M. (1990) Neurotransmitters and neuromodulators in the basal ganglia, Trends Neurosci., 13, 244–253.
Hikosaka, O. and Wurtz, R. H. (1983) Visual and oculomotor functions of monkey substantia nigra pars reticulata, parts 1–4, J. Neurophysiol., 49, 1232–1301.
Hore, J. and Vilis, T. (1980) Arm movement performance during reversible basal ganglia lesions in the monkey, Exp. Brain Res., 39, 217–228.
Lamarre, Y. and Joffroy, A. J. (1979) Experimental tremor in monkey: activity of thalamic and precentral cortical neurones in the absence of peripheral feedback, Adv. Neurol., 24, 109–122.
Lindvall, O., Widner, H., Rehncrona, S. et al. (1992) Transplantation of foetal dopamine neurons in Parkinson’s disease: one year clinical and neurophysiological observations in two patients with putaminal implants, Ann. Neurol., 31, 155–165.
Marsden, C. D. (1984) Origins of normal and pathological tremor, in L. J. Findley and R. Capildeo (eds), Movement Disorders: Tremor, Macmillan, London, pp. 37–84.
Marsden, C. D. (1990) Neurophysiology, in G. Stern (ed.) Parkinson’s Disease, Chapman & Hall, London, pp. 57–98.
Martin, J. P. (1967) The Basal Ganglia and Posture, Lippincott, Philadelphia.
Meara, R. J. and Cody, F. W. J. (1992) Relationship between electromyographic activity and clinically assessed rigidity studied at the wrist joint in Parkinson’s disease, Brain, 115, 1167–1180.
Mink, J. W. and Thach, W. T. (1991) Basal ganglia motor control, Parts 1, 2, and 3, J. Neurophysiol., 65, 273–351.
Pechadre, J. C, Larochelle, L. and Poirier, L. J. (1976) Parkinsonian akinesia, rigidity and tremor in the monkey, J. Neurol Sci., 28, 147–157.
Romo, R. and Schultz, W. (1990) Dopamine neurones of the monkey midbrain: contigences of responses to active touch to self-initiated arm movement, J. Neurophysiol, 63, 592–606; 607-624.
Rothwell, J. C., Obeso, J. A., Day, B. L. et al. (1983a) Pathophysiology of dystonias, Adv. Neurol, 39, 851–863.
Rothwell, J. C, Obeso, J. A., Traub, M. M. et al. (1983b) The behaviour of the long-latency stretch reflex in patients with Parkinson’s disease, J. Neurol. Neurosurg. Psychiatr., 46, 35–44.
Schwab, R. S., Chafetz, M. E. and Walker, S. (1954) Control of two simultaneous motor acts in normals and in parkinsonism, Arch. Neurol Psychiatr., 72, 591–598.
Smith, A. D. and Bolam, J. P. (1990) The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones, Trends Neurosci., 13, 259–265.
Thompson, P. D., Berardelli, A., Rothwell, J. C. et al. (1988) The coexistence of bradykinesia and chorea in Huntington’s disease and its implications for theories of basal ganglia control of movement, Brain, 111, 223–244.
Traub, M. M., Rothwell, J. C. and Marsden, C. D. (1980) Anticipatory postural reflexes in Parkinson’s disease and other akinetic-rigid syndromes and in cerebellar ataxia, Brain, 103, 393–412.
Tremblay, L., Filion, M. and Bedard, P. J. (1989) Responses of pallidal neurones to striatal stimulation in monkeys with MPTP induced parkinsonism, Brain Res., 498, 17–33.
Williams, P. L. and Warwick, R. (1975) Functional Neuro-anatomy of Man, Churchill Livingstone, Edinburgh.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1994 John Rothwell
About this chapter
Cite this chapter
Rothwell, J. (1994). The basal ganglia. In: Control of Human Voluntary Movement. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6960-8_11
Download citation
DOI: https://doi.org/10.1007/978-94-011-6960-8_11
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-412-47700-3
Online ISBN: 978-94-011-6960-8
eBook Packages: Springer Book Archive