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Monoclonal antibodies against the terminal complement components

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Activators and Inhibitors of Complement

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Abstract

Classical or alternative pathway activation of the complement system results in the formation of the terminal complement complex (TCC), made up of the components C5, C6, C7, C8 and C9. In this review, the term membrane attack complex (MAC) is used only to describe the C5b-9(m) complex, the potentially membranolytic form of the TCC generated on biological membranes [1]. The term SC5b-9 is used to describe the generally non-lytic form of the TCC, generated in extracellular fluids in the presence of S-protein [2]. A diagram of the structures and assembly of C5–C9 is shown in Figure 1.

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  1. MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK

    Robert B. Sim (Medical Research Council Scientific Staff and University Research Lecturer) (Medical Research Council Scientific Staff and University Research Lecturer)

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Würzner, R. (1993). Monoclonal antibodies against the terminal complement components. In: Sim, R.B. (eds) Activators and Inhibitors of Complement. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2757-8_7

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  • DOI: https://doi.org/10.1007/978-94-011-2757-8_7

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