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Genetics and molecular biology of manic-depression

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Molecular and Cell Biology of Neuropsychiatric Diseases

Part of the book series: Molecular and Cell Biology of Human Diseases Series ((Mol. Cell Biol. Hu. Dis.))

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Abstract

There is not yet a defined molecular biology of manic-depression. There are no DNA mutations known to predispose to the disorder. Genes have not been identified that are functionally abnormal in patients. Genetic linkage to polymorphic markers in multiply affected families has not been convincingly established, nor are there any DNA or classical markers clearly associated with liability to develop the condition. Indeed it is possible to go further and say that there is not yet a biology of manic-depression. Biological research has been unable so far to identify markers of trait, as a basis for the application of molecular methods, and indeed as a basis for the better identification of the syndrome itself. Such a biological marker would greatly assist identification of cases for genetic studies, as for example the measurement of blood sugar can assist in the diagnosis of subclinical diabetes mellitis. Unfortunately, the diagnosis of manic-depression depends on clinical recognition of a constellation of symptoms that may or may not be present at the time of assessment.

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References

  • Andreason, N.C. (1986) The family history approach to diagnosis: how useful is it? Arch. Gen. Psychiatry, 43, 421–429.

    Article  Google Scholar 

  • Avissar, S., Schreiber, G., Danon, A. et al. (1988) Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex. Nature, 331, 440–442.

    Article  PubMed  CAS  Google Scholar 

  • Baron, M. (1977) Linkage between an X-chromosome marker (deuton color blindness) and bipolar affective illness. Arch. Gen. Psychiatry, 34, 721–725.

    Article  PubMed  CAS  Google Scholar 

  • Baron, M., Endicott, J. and Ott, S. (1990) Genetic linkage in mental illness. Br. J. Psychiatry, 157, 645–655.

    Article  PubMed  CAS  Google Scholar 

  • Baron, M., Risch, N., Hamburger, R. et al. (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature, 326, 289–292.

    Article  PubMed  CAS  Google Scholar 

  • Baron, M., Hamburger, R., Sandkuyl, L.A. et al. (1990) The impact of phenotypic variation on genetic analysis: application to X-linkage in manic-depressive illness. Acta Psychiat. Scand., 82, 196–203.

    Article  PubMed  CAS  Google Scholar 

  • Belmaker, R.H. (1981) Biological Psychiatry, 16, 333–349.

    PubMed  CAS  Google Scholar 

  • Berrettini, W., Goldin, L.R., Gelernter, J. et al. (1990) X-chromosome markers and manic-depressive illness: rejection of linkage in nine bipolar pedigrees. Arch. Gen. Psychiatry, 47, 366–373.

    Article  PubMed  CAS  Google Scholar 

  • Bertelsen, A., Harvald, B. and Hauge, M. (1977) A Danish twin study of manicdepressive disorders. Br. J. Psychiatry, 130, 330–351.

    Article  PubMed  CAS  Google Scholar 

  • Breakefield, X.O., Edelstein, S.B., Grossman, M.H. and Schwartz, J.P. (1981) Variations in MAO and NGF in cultured human skin fibroblasts, in Genetic Research Strategies in Psychobiology and Psychiatry, (eds D.B. Gershon, S. Matthysse and X.O. Breakefield), Boxwood Press, Pacific Grove, California.

    Google Scholar 

  • Bunney, W.E and Davis, J.M. (1965) Norepinephrine in depressive reactions. Arch. Gen. Psychiatry, 13, 483–494.

    Article  PubMed  CAS  Google Scholar 

  • Cadoret, R.J. (1978) Evidence for genetic inheritance of primary affective disorders in adoptees. Am. J. Psychiatry, 135, 463–466.

    PubMed  CAS  Google Scholar 

  • Cadoret, R.J., O’Gorman, T.W., Heywood, E. and Troughton, E. (1985) Genetic and environmental factors in major depression. J. Affect. Disorders, 9, 155–164.

    Article  PubMed  CAS  Google Scholar 

  • Carroll, B.J. (1984) Problems with diagnostic criteria for depression: diagnostic criteria. J. Clin. Psychiatry, 45, 14–18.

    PubMed  CAS  Google Scholar 

  • Clerget-Darpoux, F., Bonaiti-Pellie, C., Hochez, J. et al. (1986) Effects of misspecifying genetic parameters in LOD score analysis. Biometrics, 42, 393–399.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, D.M. and Clayton, J.F. (1988) DNA polymorphism and the study of disease associations. Hum. Gen., 78, 299–312.

    Article  CAS  Google Scholar 

  • Craddock, N. and Owen, M.J. (1992) Christmas disease and major affective disorder (letter). Br. J. Psychiatry, 160, 715.

    Article  PubMed  CAS  Google Scholar 

  • Detera-Wadleigh, S.D., Berrettini, W., Goldin, L.R. et al. (1987) Close linkage of c-Harvey-ras 1 and insulin gene to affective disorder is ruled out in three North American pedigrees. Nature, 325, 806–808.

    Article  PubMed  CAS  Google Scholar 

  • DelZompo, M., Bochetta, A. and Goldin, L.R. (1984) Linkage between X-chromosome markers and manic depressive illness: two Sardinian pedigrees. Acta Psychiat. Scand., 70, 282–287.

    Article  CAS  Google Scholar 

  • Egeland, J.A., Gerhard, D.S., Pauls, D.L. et al. (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature, 325, 783–787.

    Article  PubMed  CAS  Google Scholar 

  • Faraone, S.V., Lyons, M.J. and Tsuang, M.T. (1987) Sex differences in affective disorder: genetic transmission. Genetic Epidemiology, 4, 331–343.

    Article  PubMed  CAS  Google Scholar 

  • Ferns, G.A., Stocks, J. and Galton, D.J. (1986) C-III DNA restriction fragment length polymorphism and myocardial infarction. Lancet, 1, 94.

    Article  PubMed  CAS  Google Scholar 

  • Froguel, Ph., Vaxillaire, M., Sun, F. et al. (1992) Close linkage of glucokinase locus on chromosome 7p to early onset non-insulin-dependent diabetes mellitus. Nature, 356, 162–167.

    Article  PubMed  CAS  Google Scholar 

  • Gershon, E.S., Baron, M. and Leckman, J.F. (1975) Genetic models for the transmission of affective disorders. J. Psychiatric Res., 12, 301–317.

    Article  Google Scholar 

  • Gershon, E.S., Targum, S.D., Matthysse, S. et al. (1979) Colour blindness not closely linked to bipolar illness. Arch. Gen. Psychiatry, 36, 1423–1430.

    Article  PubMed  CAS  Google Scholar 

  • Gershon, E.S., Goldin, L.R., Lake, C.R. et al. (1980) Genetics of plasma dopamine-γ-hydroxylase (DBH), Erythrocyte catechol-O-methyltransferase (COMT) and platelet monoamine oxidase (MAO) in pedigrees and patients with affective disorders, in Enzymes and Neurotransmitters in Mental Disease, (eds. Usdin, L. Stourkes and M.B.H. Young), Wiley, New York.

    Google Scholar 

  • Gill, M., Castle, D. and Duggan, C. (1992) Co-segregation of Christmas disease and major affective disorder in a pedigree. Br. J. Psychiatry, 160, 112–114.

    Article  PubMed  CAS  Google Scholar 

  • Gill, M., McKeon, P. and Humphries, P. (1988) Linkage analysis of manic depression in an Irish family using H-ras 1 and INS DNA markers. J. Med. Gen., 25, 634–637.

    Article  CAS  Google Scholar 

  • Gill, M., Castle, D., Hunt, N. et al. (1991) Tyrosine hydroxylase polymorphisms and bipolar affective disorder. J. Psychiatric Res., 25, 179–184.

    Article  CAS  Google Scholar 

  • Goldin, L.R., Clerget-Darpoux, F. and Gershon, E.S. (1982) Relationship of HLA to major affective disorder not supported. Psychiatry Research, 7, 29–45.

    Article  PubMed  CAS  Google Scholar 

  • Grima, B., Lamouroux, A., Boni, C. et al. (1987) A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics. Nature, 326, 707–711.

    Article  PubMed  CAS  Google Scholar 

  • Hodgkinson, S., Sherrington, R., Gurling, H. et al. (1987) Molecular genetic evidence of heterogeneity in manic-depression. Nature, 325, 805–806.

    Article  PubMed  CAS  Google Scholar 

  • Hotamisligil, G.S. and Breakefield, X.I. (1991) Human monoamine oxidase A gene determines levels of enzyme activity. Am. J. Hum. Gen., 49, 383–392.

    CAS  Google Scholar 

  • Hsu, Y-P.P., Powell, J.F., Sims K.B. and Breakefield, X.O. (1989) Molecular genetics of the monoamine oxidases. J. Neurochem., 53, 12–18.

    Article  PubMed  CAS  Google Scholar 

  • Jacob, H.J., Lindpainter, K. and Lincoln, S.E. (1991) Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell, 67, 213–224.

    Article  PubMed  CAS  Google Scholar 

  • Kelsoe, J.R., Ginns, E.I., Egeland, J. et al. (1989) Re-evaluation of the linkage relationship between chromosome lip loci and the gene for bipolar affective disorder in the Old Order Amish. Nature, 342, 238–242.

    Article  PubMed  CAS  Google Scholar 

  • Kidd, K.K., Gerhard, D.S. and Pauls, D.L. (1984) Recombinant DNA methods in genetic studies of affective disorders. Clin. Neuropharmacol., 7(Suppl. 1), 5104.

    Google Scholar 

  • Korner, J., Fritze, J. and Propping, P. (1990) RFLP alleles at the tyrosine hydroxylase locus: no association found to affective disorders. Psychiatry Research, 32, 275–280.

    Article  PubMed  CAS  Google Scholar 

  • Leboyer, M., Malafosse, A., Boularand, S. et al. (1990) Tyrosine hydroxylase polymorphisms associated with manic-depressive illness. Lancet, 335, 1219.

    Article  PubMed  CAS  Google Scholar 

  • Leckman, J.F., Gershon, E.S., Nichols, A.S. and Murphy D.L. (1977) Reduced MAO activity in first-degree relatives of individuals with bipolar affective disorders: a preliminary report. Arch. Gen. Psychiatry, 34, 601–616.

    Article  PubMed  CAS  Google Scholar 

  • Lloyd, K.G., Thuret, F. and Pilc, A. (1985) Up-regulation of γ-aminobutyric acid (GABAB) binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock. J. Pharmacol. Exp. Ther., 235, 191–199.

    PubMed  CAS  Google Scholar 

  • Lüddens, H. and Wisden, W. (1991) Function and pharmacology of multiple GABAA receptor subunits. Trends Pharmacol. Sci., 12, 49–51.

    Article  PubMed  Google Scholar 

  • McGuffin, P., Farmer, A. and Harvey, I. (1991) A polydiagnostic application of operational criteria in studies of psychotic illness: development and reliability of the OPCRIT system. Arch. Gen. Psychiatry, 48, 764–770.

    Article  PubMed  CAS  Google Scholar 

  • Mallet, J., Boni, C., Dumas, S. et al. (1987) Molecular genetics of catecholamines as an approach to the biochemistry of manic-depression. J. Psychiatric Res., 21, 559–568.

    Article  CAS  Google Scholar 

  • Maubach, M.N., Diebold, K., Fried, W. and Propping, P. (1981) Platelet MAO activity in patients with affective psychosis and their first-degree relatives. Pharmacopsychiatry, 14, 87–93.

    Article  CAS  Google Scholar 

  • Mendlewicz, J. and Fleiss, J. (1974) Linkage studies with X-chromosome markers in bipolar (manic-depression) and unipolar (depressive) illnesses. Biol. Psychiatry, 9, 261–294.

    PubMed  CAS  Google Scholar 

  • Mendlewicz, J., Fleiss, J.L. and Fieve, R.R. (1972) Evidence for X-linkage in the transmission of manic-depressive illness. J. Am. Med. Ass., 222, 1624–1627.

    Article  CAS  Google Scholar 

  • Mendlewicz, J., Linkowski, P. and Guroff, J.J. (1979) Color blindness linkage to manic-depressive illness. Arch. Gen. Psychiatry, 36, 1442–1447.

    Article  PubMed  CAS  Google Scholar 

  • Mendlewicz, J. and Rainer, J.D. (1977) Adoption study supporting genetic transmission in manic-depressive illness. Nature, 286, 326–329.

    Google Scholar 

  • Mendlewicz, J. and Stallone, F. (1975) Genetic factors and lithium response in manic-depressive illness. Genetics and Psycho-pharmacology of Problematic Pharmacopsychiatry, 10, 23–29.

    CAS  Google Scholar 

  • Mendlewicz, J., Verbanck, P., Linkowski, P. et al. (1981) HLA antigens in affective disorders and schizophrenia. J. Affect. Disorders, 3, 17–24.

    Article  PubMed  CAS  Google Scholar 

  • Mendlewicz, J., Simon, P., Sevy, S. et al. (1987) Polymorphic DNA marker on X-chromosome and manic-depression. Lancet, i, 1230–1232.

    Article  Google Scholar 

  • Mitchell, P., Waters, B., Morrison, N. et al. (1991) Close linkage of bipolar disorder to chromosome 11 markers is excluded in two large Australian pedigrees. J. Affect. Disorders, 21, 23–32.

    Article  PubMed  CAS  Google Scholar 

  • Morton, N.E. (1955) Sequential tests for the detection of linkage. Am. J. Hum. Gen., 7, 277–318.

    CAS  Google Scholar 

  • Mourant, A.E., Kopec, A.C. and Domaniewska-Sobezak, K. (1978) Blood Groups and Diseases, Oxford University Press, Oxford.

    Google Scholar 

  • O’Rourke, D.H., McGuffin, P. and Reich, T. (1983) Genetic analysis of manicdepression. Am. J. Physical Anthropology, 62, 51–59.

    Article  Google Scholar 

  • Penrose, L. (1953) The general purpose sib-pair test. Ann. Eugenics, 6, 133–138.

    Google Scholar 

  • Price, J. (1968) The genetics of depressive behaviour, in Recent Developments in Affective Disorders, (eds A.J. Coppen and A. Walk), British Journal of Psychiatry, Special Publication No. 2, Headley Bros, Kent.

    Google Scholar 

  • Reich, T., Clayton, P.J. and Winokur, G. (1969) Family history studies: V. The genetics of mania. Am. J. Psychiatry, 125, 64–75.

    Google Scholar 

  • Rice, J., Reich, T., Andreasen, N.C. et al. (1987a) The familial transmission of bipolar illness. Arch. Gen. Psychiatry, 41, 441–447.

    Article  Google Scholar 

  • Rice, J.P., Endicott, J., Knesevich, M.A. et al. (1987b) The estimation of diagnostic sensitivity using stability data: an application to major depressive disorder. J. Psychiatric Res., 21, 337–345.

    Article  CAS  Google Scholar 

  • Robins, L.N., Heizer, J.E., Weissman, M.M. et al. (1984) Lifetime prevalence of specific psychiatric disorders in three sites. Arch. Gen. Psychiatry, 41, 949–958.

    Article  PubMed  CAS  Google Scholar 

  • Rosanoff, A.J., Handy, L. and Plesset, I.R. (1935) The aetiology of manic-depressive syndromes with special references to their occurrence in twins. Am. J. Psychiatry, 91, 725–740.

    Google Scholar 

  • Sherrington, R., Dixon, P., Melmer, G. et al. (1992) Linkage disequilibrium between two highly polymorphic microsatellite sequences. Am. J. Hum. Gen., 49, 966–971.

    Google Scholar 

  • Sims, K.B., de la Chapelle, A., Norio, R. et al. (1989) Monoamine oxidase deficiency in males with an X-chromosome deletion. Neuron, 2, 1069–1076.

    Article  PubMed  CAS  Google Scholar 

  • Smeraldi, E., Negri, F., Melica, A. et al. (1978) HLA system and affective disorders: a sibship genetic study. Tissue Antigens, 12, 270.

    Article  PubMed  CAS  Google Scholar 

  • Sobell, J.L., Heston, L.L. and Sommer, S.S. (1992) Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility. Genomics, 12, 1–6.

    Article  PubMed  CAS  Google Scholar 

  • Spitzer, R.L., Endicott, J. and Robins, E. (1978) Research Diagnostic Criteria for a Selected Group of Functional Disorders, 3rd edn, New York State Psychiatric Institute, New York.

    Google Scholar 

  • Suarez, B.K. and Croughan, J. (1982) Is the major histocompatibility complex linked to genes that increase susceptibility to affective disorder? A critical appraisal. Psychiatry Research, 7, 19–27.

    Article  PubMed  CAS  Google Scholar 

  • Suarez, B.K., Rice, J. and Reich, T. (1978) The generalised sib-pair IBD distribution: its use in the detection of linkage. Ann. Hum. Gen., 42, 87–94.

    Article  CAS  Google Scholar 

  • Thompson, G. (1986) Determining the mode of inheritance of RFLP-associated diseases using the affected sib-pair method. Am. J. Hum. Gen., 39, 207–221.

    Google Scholar 

  • Tiwari, J. and Terasaki, P.I. (1985) HLA and Disease Associations, Springer, Berlin.

    Book  Google Scholar 

  • Todd, R.D. and O’Malley, K. (1989) Population frequencies of tyrosine hydroxylase restriction fragment length polymorphisms in bipolar affective disorder. Biol. Psychiatry, 25, 626–630.

    Article  PubMed  CAS  Google Scholar 

  • Tsuang, M.T., Winokur, G. and Crowe, R.R. (1980) Morbidity risks of schizophrenia and affective disorders among first-degree relatives of patients with schizophrenia, mania, depression and surgical conditions. Br. J. Psychiatry, 137, 497–504.

    Article  PubMed  CAS  Google Scholar 

  • Tsuang, M.T. and Faraone, S.V. (1990) The Genetics of Mood Disorders, The John Hopkins University Press, London.

    Google Scholar 

  • Von Knorring, L., Cloninger, C.R., Bohman, M. et al. (1983) An adoption study of depressive disorders and substance abuse. Arch. Gen. Psychiatry, 40, 943–950.

    Article  Google Scholar 

  • Walsh, C., Hicks, A., Sham, P. et al. (1992) GABAA receptor subunit genes as candidate genes for bipolar affective disorder — an association analysis. J. Psychiat. Gen., 2, 239–247.

    Article  Google Scholar 

  • Watt, D.C. and Edwards, J. (1989) Caution in locating the gene(s) for affective disorder. Psychological Medicine, 19, 273–275.

    Article  PubMed  Google Scholar 

  • Weitkamp, L.R., Stancer, H.C., Persad, E. et al. (1981) Depressive disorders and HLA: a gene on chromosome 6 that can affect behaviour. New England Journal of Medicine, 305, 1301–1306.

    Article  PubMed  CAS  Google Scholar 

  • Wender, P.H., Kety, S.S., Rosenthal, D. et al. (1986) Psychiatric disorder in the biological and adoptive families and adopted individuals with affective disorders. Arch. Gen. Psychiatry, 43, 923–929.

    Article  PubMed  CAS  Google Scholar 

  • Wing, J.K., Cooper, J.E. and Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms, Cambridge University Press, Cambridge.

    Google Scholar 

  • Winokur, G. and Tanna, V.L. (1969) Possible role of X-linked dominant factor in manic depressive disease. Diseases of the Nervous System, 30, 89–94.

    PubMed  CAS  Google Scholar 

  • Winokur, G. and Crowe, R.R. (1983) Bipolar illness: the sex-polarity effect in affectively ill family members. Arch. Gen. Psychiatry, 40, 57–58.

    Article  PubMed  CAS  Google Scholar 

  • Wood, A.J. and Goodwin, G.M. (1987) A review of the biochemical and neuropharmacological actions of lithium. Psychological Medicine, 17, 579–600.

    Article  PubMed  CAS  Google Scholar 

  • Wood, A.J., Smith, C.E., Clarke, E. E. and Cowen, P.J. (1991) Altered in vitro adaptive responses of lymphocyte Na+K+ ATPase in patients with manicdepressive psychosis. J. Affect. Disorders, 21, 199–206.

    Article  PubMed  CAS  Google Scholar 

  • Woolf, B. (1955) On estimating the relation between blood groups and disease. Ann. Hum. Gen., 19, 251–253.

    Article  CAS  Google Scholar 

  • Zigmond, R.E. (1985) Biochemical consequences of synaptic stimulation: the regulation of tyrosine hydroxylase activity by multiple transmitters. Trends Neurosciences, 8, 63–69.

    Article  CAS  Google Scholar 

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  1. Michael Gill
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  1. Department of Physiology, University of Manchester, UK

    Frank Owen

  2. Department of Optometry and Vision Sciences, UMIST, UK

    Ruth Itzhaki

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Gill, M. (1994). Genetics and molecular biology of manic-depression. In: Owen, F., Itzhaki, R. (eds) Molecular and Cell Biology of Neuropsychiatric Diseases. Molecular and Cell Biology of Human Diseases Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0709-9_8

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