Abstract
An all-synthetic approach towards artificial ion channels is described. This approach relies on conceiving a channel as extended molecule where binding sites alternate with structural elements, and where all binding cavities are occupied. According to this model, ion movement is conceived as synchronized translocation of the guest ions from one cavity to its neighbor. The realization of this idea is demonstrated here with triple-stranded helical molecules that bind two metal ions, specifically ferric ions, in a string. The use of ferric ions, rather than alkali metal ions, allows easy spectrometric analysis of these molecules’ structure and of the ion translocation process. The latter is demonstrated to involve stepwise ion movement with concurrent rearrangement. Extension of such structures to span whole membranes is indicated.
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© 1988 Kluwer Academic Publishers
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Shanzer, A., Libman, J., Tor, Y., Gottlieb, H. (1988). Helical Structures; Artificial Solutions for Ion Transport. In: Pullman, A., Jortner, J., Pullman, B. (eds) Transport Through Membranes: Carriers, Channels and Pumps. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 21. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3075-9_4
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DOI: https://doi.org/10.1007/978-94-009-3075-9_4
Publisher Name: Springer, Dordrecht
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