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Peroxisome Interactions and Cross-Talk with Other Subcellular Compartments in Animal Cells

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Book cover Peroxisomes and their Key Role in Cellular Signaling and Metabolism

Part of the book series: Subcellular Biochemistry ((SCBI,volume 69))

Abstract

Peroxisomes are remarkably plastic and dynamic organelles, which fulfil important functions in hydrogen peroxide and lipid metabolism rendering them essential for human health and development. Despite great advances in the identification and characterization of essential components and molecular mechanisms associated with the biogenesis and function of peroxisomes, our understanding of how peroxisomes are incorporated into metabolic pathways and cellular communication networks is just beginning to emerge. Here we address the interaction of peroxisomes with other subcellular compartments including the relationship with the endoplasmic reticulum, the peroxisome-mitochondria connection and the association with lipid droplets. We highlight metabolic cooperations and potential cross-talk and summarize recent findings on peroxisome-peroxisome interactions and the interaction of peroxisomes with microtubules in mammalian cells.

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References

  • Aboushadi N, Engfelt WH, Paton VG, Krisans SK (1999) Role of peroxisomes in isoprenoid biosynthesis. J Histochem Cytochem 47:1127–1132

    Article  PubMed  CAS  Google Scholar 

  • Agrawal G, Joshi S, Subramani S (2011) Cell-free sorting of peroxisomal membrane proteins from the endoplasmic reticulum. Proc Natl Acad Sci USA 108:9113–9118

    Article  PubMed  CAS  Google Scholar 

  • Antonenkov VD, Hiltunen JK (2011) Transfer of metabolites across the peroxisomal membrane. Biochim Biophys Acta 1822:1374–1386

    PubMed  Google Scholar 

  • Antonenkov VD, Grunau S, Ohlmeier S, Hiltunen JK (2010) Peroxisomes are oxidative organelles. Antioxid Redox Signal 13:525–537

    Article  PubMed  CAS  Google Scholar 

  • Appelkvist EL, Reinhart M, Fischer R, Billheimer J, Dallner G (1990) Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes. Arch Biochem Biophys 282:318–325

    Article  PubMed  CAS  Google Scholar 

  • Arimura S, Yamamoto J, Aida GP, Nakazono M, Tsutsumi N (2004) Frequent fusion and fission of plant mitochondria with unequal nucleoid distribution. Proc Natl Acad Sci USA 101:7805–7808

    Article  PubMed  CAS  Google Scholar 

  • Baumgart E, Vanhorebeek I, Grabenbauer M, Borgers M, Declercq PE, Fahimi HD, Baes M (2001) Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse). Am J Pathol 159:1477–1494

    Article  PubMed  CAS  Google Scholar 

  • Beller M, Thiel K, Thul PJ, Jackle H (2010) Lipid droplets: a dynamic organelle moves into focus. FEBS Lett 584:2176–2182

    Article  PubMed  CAS  Google Scholar 

  • Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, Herrmann C et al (2011) PEX14 is required for microtubule-based peroxisome motility in human cells. J Cell Sci 124:1759–1768

    Article  PubMed  CAS  Google Scholar 

  • Binns D, Januszewski T, Chen Y, Hill J, Markin VS, Zhao Y, Gilpin C et al (2006) An intimate collaboration between peroxisomes and lipid bodies. J Cell Biol 173:719–731

    Article  PubMed  CAS  Google Scholar 

  • Bonekamp NA, Volkl A, Fahimi HD, Schrader M (2009) Reactive oxygen species and peroxisomes: struggling for balance. Biofactors 35:346–355

    Article  PubMed  CAS  Google Scholar 

  • Bonekamp NA, Fahimi HD, Schrader M (2011) Oxidative stress in peroxisomes. In: Pantopoulos K, Shipper H (eds) Principles of free radical biomedicine. Nova Science Publishers, Hauppage, pp 333–358

    Google Scholar 

  • Bonekamp NA, Sampaio P, de Abreu FV, Luers GH, Schrader M (2012) Transient complex interactions of mammalian peroxisomes without exchange of matrix or membrane marker proteins. Traffic 13:960–978

    Article  PubMed  CAS  Google Scholar 

  • Braverman NE, Moser AB (2012) Functions of plasmalogen lipids in health and disease. Biochim Biophys Acta 1822:1442–1452

    Article  PubMed  CAS  Google Scholar 

  • Brocard CB, Boucher KK, Jedeszko C, Kim PK, Walton PA (2005) Requirement for microtubules and dynein motors in the earliest stages of peroxisome biogenesis. Traffic 6:386–395

    Article  PubMed  CAS  Google Scholar 

  • Camoes F, Bonekamp NA, Delille HK, Schrader M (2009) Organelle dynamics and dysfunction: a closer link between peroxisomes and mitochondria. J Inherit Metab Dis 32:163–180

    Article  PubMed  CAS  Google Scholar 

  • Chang CR, Manlandro CM, Arnoult D, Stadler J, Posey AE, Hill RB, Blackstone C (2010) A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division. J Biol Chem 285:32494–32503

    Article  PubMed  CAS  Google Scholar 

  • Chuong SD, Park NI, Freeman MC, Mullen RT, Muench DG (2005) The peroxisomal multifunctional protein interacts with cortical microtubules in plant cells. BMC Cell Biol 6:40

    Article  PubMed  CAS  Google Scholar 

  • Clastre M, Papon N, Courdavault V, Giglioli-Guivarc’h N, St-Pierre B, Simkin AJ (2011) Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. Plant Signal Behav 6:2044–2046

    Article  PubMed  CAS  Google Scholar 

  • Clauset A, Shalizi CR, Newman MEJ (2009) Power-law distributions in empirical data. SIAM Rev 51:661–703

    Article  Google Scholar 

  • de Brito OM, Scorrano L (2008) Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456:605–610

    Article  PubMed  CAS  Google Scholar 

  • Delille HK, Agricola B, Guimaraes SC, Borta H, Luers GH, Fransen M, Schrader M (2010) Pex11pbeta-mediated growth and division of mammalian peroxisomes follows a maturation pathway. J Cell Sci 123:2750–2762

    Article  PubMed  CAS  Google Scholar 

  • Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S et al (2011) Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med 17:1121–1127

    Article  PubMed  CAS  Google Scholar 

  • Dirkx R, Vanhorebeek I, Martens K, Schad A, Grabenbauer M, Fahimi D, Declercq P et al (2005) Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities. Hepatology 41:868–878

    Article  PubMed  CAS  Google Scholar 

  • Fagarasanu A, Mast FD, Knoblach B, Rachubinski RA (2010) Molecular mechanisms of organelle inheritance: lessons from peroxisomes in yeast. Nat Rev Mol Cell Biol 11:644–654

    Article  PubMed  CAS  Google Scholar 

  • Fahimi HD, Yokota S (1981) Ultrastructural and cytochemical aspects of animal peroxisomes – some recent observations. In: Schweiger HG (ed) Internat Cell Biol, Springer Berlin-Heidelberg, pp 640–650

    Google Scholar 

  • Fahimi HD, Kalmbach P, Stegmeier K, Stork H (1980) Comparison between the effects of clofibrate and bezafibrate upon the ultrastructure of rat heart and liver. In: Greten H, Lang PD, Schettler G (eds) Lipoprot & Coronary Disease, G Witzstrock Publishing House, New York/Baden-Baden/Cologne, pp 64–75

    Google Scholar 

  • Ferdinandusse S, Denis S, Faust PL, Wanders RJ (2009) Bile acids: the role of peroxisomes. J Lipid Res 50:2139–2147

    Article  PubMed  CAS  Google Scholar 

  • Fransen M, Nordgren M, Wang B, Apanasets O (2012) Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochim Biophys Acta 1822:1363–1373

    Article  PubMed  CAS  Google Scholar 

  • Geuze HJ, Murk JL, Stroobants AK, Griffith JM, Kleijmeer MJ, Koster AJ, Verkleij AJ et al (2003) Involvement of the endoplasmic reticulum in peroxisome formation. Mol Biol Cell 14:2900–2907

    Article  PubMed  CAS  Google Scholar 

  • Gorgas K (1985) Serial section analysis of mouse hepatic peroxisomes. Anat Embryol (Berl) 172:21–32

    Article  CAS  Google Scholar 

  • Gorgas K, Teigler A, Komljenovic D, Just WW (2006) The ether lipid-deficient mouse: tracking down plasmalogen functions. Biochim Biophys Acta 1763:1511–1526

    Article  PubMed  CAS  Google Scholar 

  • Grabenbauer M, Satzler K, Baumgart E, Fahimi HD (2000) Three-dimensional ultrastructural analysis of peroxisomes in HepG2 cells. Absence of peroxisomal reticulum but evidence of close spatial association with the endoplasmic reticulum. Cell Biochem Biophys 32:37–49

    Article  PubMed  CAS  Google Scholar 

  • Heinemann P, Just WW (1992) Peroxisomal protein import. In vivo evidence for a novel translocation competent compartment. FEBS Lett 300:179–182

    Article  PubMed  CAS  Google Scholar 

  • Herzog V, Fahimi HD (1976) Identification of peroxisomes (microbodies) in mouse myocardium. J Mol Cell Cardiol 8:271–281

    Google Scholar 

  • Hettema EH, Girzalsky W, van Den Berg M, Erdmann R, Distel B (2000) Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins. EMBO J 19:223–233

    Article  PubMed  CAS  Google Scholar 

  • Hicks L, Fahimi HD (1977) Peroxisomes (microbodies) in the myocardium of rodents and primates. A comparative ultrastructural cytochemical study. Cell Tissue Res 175:467–481

    Google Scholar 

  • Hoepfner D, Schildknegt D, Braakman I, Philippsen P, Tabak HF (2005) Contribution of the endoplasmic reticulum to peroxisome formation. Cell 122:85–95

    Article  PubMed  CAS  Google Scholar 

  • Huybrechts SJ, Van Veldhoven PP, Brees C, Mannaerts GP, Los GV, Fransen M (2009) Peroxisome dynamics in cultured mammalian cells. Traffic 10:1722–1733

    Article  PubMed  CAS  Google Scholar 

  • Hwang I, Lee J, Huh JY, Park J, Lee HB, Ho YS, Ha H (2012) Catalase deficiency accelerates diabetic renal injury through peroxisomal dysfunction. Diabetes 61:728–738

    Article  PubMed  CAS  Google Scholar 

  • Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H et al (2009) Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol 11:958–966

    Article  PubMed  CAS  Google Scholar 

  • Islinger M, Schrader M (2011) Peroxisomes. Curr Biol 21:R800–R801

    Article  PubMed  CAS  Google Scholar 

  • Islinger M, Luers GH, Zischka H, Ueffing M, Volkl A (2006) Insights into the membrane proteome of rat liver peroxisomes: microsomal glutathione-S-transferase is shared by both subcellular compartments. Proteomics 6:804–816

    Article  PubMed  CAS  Google Scholar 

  • Islinger M, Li KW, Loos M, Liebler S, Angermuller S, Eckerskorn C, Weber G et al (2010) Peroxisomes from the heavy mitochondrial fraction: isolation by zonal free flow electrophoresis and quantitative mass spectrometrical characterization. J Proteome Res 9:113–124

    Article  PubMed  CAS  Google Scholar 

  • Islinger M, Grille S, Fahimi HD, Schrader M (2012) The peroxisome: an update on mysteries. Histochem Cell Biol 137:547–574

    Article  PubMed  CAS  Google Scholar 

  • Itoyama A, Honsho M, Abe Y, Moser A, Yoshida Y, Fujiki Y (2012) Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division. J Cell Sci 125:589–602

    Article  PubMed  CAS  Google Scholar 

  • Ivashchenko O, Van Veldhoven PP, Brees C, Ho YS, Terlecky SR, Fransen M (2011) Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk. Mol Biol Cell 22:1440–1451

    Article  PubMed  CAS  Google Scholar 

  • Jourdain I, Sontam D, Johnson C, Dillies C, Hyams JS (2008) Dynamin-dependent biogenesis, cell cycle regulation and mitochondrial association of peroxisomes in fission yeast. Traffic 9:353–365

    Article  PubMed  CAS  Google Scholar 

  • Kanzawa N, Shimozawa N, Wanders RJ, Ikeda K, Murakami Y, Waterham HR, Mukai S et al (2012) Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome and rhizomelic chondrodysplasia punctata. J Lipid Res 53:653–663

    Article  PubMed  CAS  Google Scholar 

  • Karnik SK, Trelease RN (2007) Arabidopsis peroxin 16 trafficks through the ER and an intermediate compartment to pre-existing peroxisomes via overlapping molecular targeting signals. J Exp Bot 58:1677–1693

    Article  PubMed  CAS  Google Scholar 

  • Keller GA, Barton MC, Shapiro DJ, Singer SJ (1985) 3-Hydroxy-3-methylglutaryl-coenzyme a reductase is present in peroxisomes in normal rat liver cells. Proc Natl Acad Sci USA 82:770–774

    Article  PubMed  CAS  Google Scholar 

  • Kim PK, Mullen RT, Schumann U, Lippincott-Schwartz J (2006) The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER. J Cell Biol 173:521–532

    Article  PubMed  CAS  Google Scholar 

  • Koch A, Thiemann M, Grabenbauer M, Yoon Y, McNiven MA, Schrader M (2003) Dynamin-like protein 1 is involved in peroxisomal fission. J Biol Chem 278:8597–8605

    Article  PubMed  CAS  Google Scholar 

  • Koch A, Yoon Y, Bonekamp NA, McNiven MA, Schrader M (2005) A role for fis1 in both mitochondrial and peroxisomal fission in Mammalian cells. Mol Biol Cell 16:5077–5086

    Article  PubMed  CAS  Google Scholar 

  • Kovacs WJ, Shackelford JE, Tape KN, Richards MJ, Faust PL, Fliesler SJ, Krisans SK (2004) Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model. Mol Cell Biol 24:1–13

    Article  PubMed  CAS  Google Scholar 

  • Kovacs WJ, Tape KN, Shackelford JE, Duan X, Kasumov T, Kelleher JK, Brunengraber H, Krisans SK (2007) Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Histochem Cell Biol 127:273–290

    Article  PubMed  CAS  Google Scholar 

  • Kovacs WJ, Tape KN, Shackelford JE, Wikander TM, Richards MJ, Fliesler SJ, Krisans SK, Faust PL (2009) Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress. J Biol Chem 284:7232–7245

    Article  PubMed  CAS  Google Scholar 

  • Kural C, Kim H, Syed S, Goshima G, Gelfand VI, Selvin PR (2005) Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement? Science 308:1469–1472

    Article  PubMed  CAS  Google Scholar 

  • Lam SK, Yoda N, Schekman R (2010) A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum. Proc Natl Acad Sci USA 107:21523–21528

    Article  PubMed  CAS  Google Scholar 

  • Lazarow PB, Fujiki Y (1985) Biogenesis of peroxisomes. Annu Rev Cell Biol 1:489–530

    Article  PubMed  CAS  Google Scholar 

  • Luers G, Hashimoto T, Fahimi HD, Volkl A (1993) Biogenesis of peroxisomes: isolation and characterization of two distinct peroxisomal populations from normal and regenerating rat liver. J Cell Biol 121:1271–1280

    Article  PubMed  CAS  Google Scholar 

  • McCartney AW, Greenwood JS, Fabian MR, White KA, Mullen RT (2005) Localization of the tomato bushy stunt virus replication protein p33 reveals a peroxisome-to-endoplasmic reticulum sorting pathway. Plant Cell 17:3513–3531

    Article  PubMed  CAS  Google Scholar 

  • Meijer J, Afzelius B (1989) Effects of clofibrate treatment and of starvation on peroxisomes, mitochondria, and lipid droplets in mouse hepatocytes: a morphometric study. J Ultrastruct Mol Struct Res 102:87–94

    Article  PubMed  CAS  Google Scholar 

  • Mihalik SJ, Steinberg SJ, Pei Z, Park J, Kim DG, Heinzer AK, Dacremont G et al (2002) Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. J Biol Chem 277:24771–24779

    Article  PubMed  CAS  Google Scholar 

  • Miyagishima S, Nishimura M, Itoh R, Toda K, Kuroiwa H, Kuroiwa T (1999) Microbody proliferation and segregation cycle in the single microbody-alga Cyanidioschyzon merolae. Planta 208:326–336

    Article  CAS  Google Scholar 

  • Motley AM, Hettema EH (2007) Yeast peroxisomes multiply by growth and division. J Cell Biol 178:399–410

    Article  PubMed  CAS  Google Scholar 

  • Murphy S, Martin S, Parton RG (2009) Lipid droplet-organelle interactions; sharing the fats. Biochim Biophys Acta 1791:441–447

    Article  PubMed  CAS  Google Scholar 

  • Nagotu S, Saraya R, Otzen M, Veenhuis M, van der Klei IJ (2008) Peroxisome proliferation in Hansenula polymorpha requires Dnm1p which mediates fission but not de novo formation. Biochim Biophys Acta 1783:760–769

    Article  PubMed  CAS  Google Scholar 

  • Neuspiel M, Schauss AC, Braschi E, Zunino R, Rippstein P, Rachubinski RA, Andrade-Navarro MA, McBride HM (2008) Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr Biol 18:102–108

    Article  PubMed  CAS  Google Scholar 

  • Nguyen T, Bjorkman J, Paton BC, Crane DI (2006) Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance. J Cell Sci 119:636–645

    Article  PubMed  CAS  Google Scholar 

  • Novikoff PM, Novikoff AB (1972) Peroxisomes in absorptive cells of mammalian small intestine. J Cell Biol 53:532–560

    Article  PubMed  CAS  Google Scholar 

  • Novikoff AB, Shin WY (1964) The endoplasmic reticulum in the Golgi zone and its relations to microbodies, Golgi apparatus, and autophagic vacuoles in rat liver cells. J Microscopy 3:187–206

    Google Scholar 

  • Novikoff AB, Novikoff PM, Rosen OM, Rubin CS (1980) Organelle relationships in cultured 3T3-L1 preadipocytes. J Cell Biol 87:180–196

    Article  PubMed  CAS  Google Scholar 

  • Peeters A, Fraisl P, van den Berg S, Loren V, van Themaat E, Van Kampen A, Rider MH, Takemori H et al (2011) Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) suppression. J Biol Chem 286:42162–42179

    Article  PubMed  CAS  Google Scholar 

  • Perry RJ, Mast FD, Rachubinski RA (2009) Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis. Eukaryot Cell 8:830–843

    Article  PubMed  CAS  Google Scholar 

  • Poirier Y, Antonenkov VD, Glumoff T, Hiltunen JK (2006) Peroxisomal beta-oxidation–a metabolic pathway with multiple functions. Biochim Biophys Acta 1763:1413–1426

    Article  PubMed  CAS  Google Scholar 

  • Pu J, Ha CW, Zhang S, Jung JP, Huh WK, Liu P (2011) Interactomic study on interaction between lipid droplets and mitochondria. Protein Cell 2:487–496

    Article  PubMed  CAS  Google Scholar 

  • Raychaudhuri S, Prinz WA (2008) Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum. Proc Natl Acad Sci USA 105:15785–15790

    Article  PubMed  CAS  Google Scholar 

  • Rodríguez-Serrano M, Romero-Puertas MC, Sparkes I, Hawes C, del Río LA, Sandalio LM (2009) Peroxisome dynamics in Arabidopsis plants under oxidative stress induced by cadmium. Free Radic Biol Med 47:1632–1639

    Article  PubMed  CAS  Google Scholar 

  • Rucktäschel R, Halbach A, Girzalsky W, Rottensteiner H, Erdmann R (2010) De novo synthesis of peroxisomes upon mitochondrial targeting of Pex3p. Eur J Cell Biol 89:947–954

    Article  PubMed  CAS  Google Scholar 

  • Russell DW (2003) The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72:137–174

    Article  PubMed  CAS  Google Scholar 

  • Saraya R, Krikken AM, Veenhuis M, van der Klei IJ (2011) Peroxisome reintroduction in Hansenula polymorpha requires Pex25 and Rho1. J Cell Biol 193:885–900

    Article  PubMed  CAS  Google Scholar 

  • Schepers L, Casteels M, Verheyden K, Parmentier G, Asselberghs S, Eyssen HJ, Mannaerts GP (1989) Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver. Biochem J 257:221–229

    PubMed  CAS  Google Scholar 

  • Schrader M (2001) Tubulo-reticular clusters of peroxisomes in living COS-7 cells: dynamic behavior and association with lipid droplets. J Histochem Cytochem 49:1421–1429

    Article  PubMed  CAS  Google Scholar 

  • Schrader M, Fahimi HD (2006a) Growth and division of peroxisomes. Int Rev Cytol 255:237–290

    Article  PubMed  CAS  Google Scholar 

  • Schrader M, Fahimi HD (2006b) Peroxisomes and oxidative stress. Biochim Biophys Acta 1763:1755–1766

    Article  PubMed  CAS  Google Scholar 

  • Schrader M, Yoon Y (2007) Mitochondria and peroxisomes: are the ‘Big Brother’ and the ‘Little Sister’ closer than assumed? Bioessays 29:1105–1114

    Article  PubMed  CAS  Google Scholar 

  • Schrader M, Burkhardt JK, Baumgart E, Luers G, Spring H, Volkl A, Fahimi HD (1996) Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-active drugs. Eur J Cell Biol 69:24–35

    PubMed  CAS  Google Scholar 

  • Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D et al (1998) Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. J Biol Chem 273:29607–29614

    Article  PubMed  CAS  Google Scholar 

  • Schrader M, King SJ, Stroh TA, Schroer TA (2000) Real time imaging reveals a peroxisomal reticulum in living cells. J Cell Sci 113:3663–3671

    PubMed  CAS  Google Scholar 

  • Schrader M, Thiemann M, Fahimi HD (2003) Peroxisomal motility and interaction with microtubules. Microsc Res Tech 61:171–178

    Article  PubMed  CAS  Google Scholar 

  • Schrader M, Bonekamp NA, Islinger M (2012) Fission and proliferation of peroxisomes. Biochim Biophys Acta 822:1343–1357

    Google Scholar 

  • Simkin AJ, Guirimand G, Papon N, Courdavault V, Thabet I, Ginis O, Bouzid S et al (2011) Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. Planta 234:903–914

    Article  PubMed  CAS  Google Scholar 

  • Smith BT, Sengupta TK, Singh I (2000) Intraperoxisomal localization of very-long-chain fatty acyl-CoA synthetase: implication in X-adrenoleukodystrophy. Exp Cell Res 254:309–320

    Article  PubMed  CAS  Google Scholar 

  • South ST, Gould SJ (1999) Peroxisome synthesis in the absence of preexisting peroxisomes. J Cell Biol 144:255–266

    Google Scholar 

  • Sprecher H, Chen Q (1999) Polyunsaturated fatty acid biosynthesis: a microsomal-peroxisomal process. Prostaglandins Leukot Essent Fatty Acids 60:317–321

    Article  PubMed  CAS  Google Scholar 

  • Stier H, Fahimi HD, Van Veldhoven PP, Mannaerts GP, Volkl A, Baumgart E (1998) Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor alpha (PPAR alpha). Differentiation 64:55–66

    Article  PubMed  CAS  Google Scholar 

  • Su HM, Moser AB, Moser HW, Watkins PA (2001) Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis. J Biol Chem 276:38115–38120

    PubMed  CAS  Google Scholar 

  • Tanabe Y, Maruyama J, Yamaoka S, Yahagi D, Matsuo I, Tsutsumi N, Kitamoto K (2011) Peroxisomes are involved in biotin biosynthesis in Aspergillus and Arabidopsis. J Biol Chem 286:30455–30461

    Article  PubMed  CAS  Google Scholar 

  • Thai TP, Rodemer C, Jauch A, Hunziker A, Moser A, Gorgas K, Just WW (2001) Impaired membrane traffic in defective ether lipid biosynthesis. Hum Mol Genet 10:127–136

    Article  PubMed  CAS  Google Scholar 

  • Thiemann M, Schrader M, Völkl A, Baumgart E, Fahimi HD (2000) Interaction of peroxisomes with microtubules. In vitro studies using a novel peroxisome-microtubule binding assay. Eur J Biochem 267:6264–6275

    Google Scholar 

  • Thoms S, Harms I, Kalies KU, Gartner J (2012) Peroxisome formation requires the endoplasmic reticulum channel protein Sec61. Traffic 13:599–609

    Article  PubMed  CAS  Google Scholar 

  • Till A, Lakhani R, Burnett SF, Subramani S (2012) Pexophagy: the selective degradation of peroxisomes. Int J Cell Biol 2012:512721

    PubMed  Google Scholar 

  • Titorenko VI, Rachubinski RA (2001) Dynamics of peroxisome assembly and function. Trends Cell Biol 11:22–29

    Article  PubMed  CAS  Google Scholar 

  • van der Zand A, Gent J, Braakman I, Tabak HF (2012) Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomes. Cell 149:397–409

    Article  PubMed  CAS  Google Scholar 

  • Voss A, Reinhart M, Sankarappa S, Sprecher H (1991) The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase. J Biol Chem 266:19995–20000

    PubMed  CAS  Google Scholar 

  • Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW, Iijima M, Sesaki H (2009) The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol 186:805–816

    Article  PubMed  CAS  Google Scholar 

  • Wanders RJ, Waterham HR (2006) Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem 75:295–332

    Article  PubMed  CAS  Google Scholar 

  • Waterham HR, Koster J, van Roermund CW, Mooyer PA, Wanders RJ, Leonard JV (2007) A lethal defect of mitochondrial and peroxisomal fission. N Engl J Med 356:1736–1741

    Article  PubMed  CAS  Google Scholar 

  • Wiemer EA, Wenzel T, Deerinck TJ, Ellisman MH, Subramani S (1997) Visualization of the peroxisomal compartment in living mammalian cells: dynamic behavior and association with microtubules. J Cell Biol 136:71–80

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto K, Fahimi HD (1987) Three-dimensional reconstruction of a peroxisomal reticulum in regenerating rat liver: evidence of interconnections between heterogeneous segments. J Cell Biol 105:713–722

    Article  PubMed  CAS  Google Scholar 

  • Yonekawa S, Furuno A, Baba T, Fujiki Y, Ogasawara Y, Yamamoto A, Tagaya M, Tani K (2011) Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells. Proc Natl Acad Sci USA 108:12746–12751

    Article  PubMed  CAS  Google Scholar 

  • Zaar K, Hartig F, Fahimi HD, Gorgas K (1984) Peroxisomal aggregates forming large stacks in the lipid segment of the canine kidney. Acta Histochem Suppl 29:165–168

    PubMed  CAS  Google Scholar 

  • Zaar K, Volkl A, Fahimi HD (1987) Association of isolated bovine kidney cortex peroxisomes with endoplasmic reticulum. Biochim Biophys Acta 897:135–142

    Article  PubMed  CAS  Google Scholar 

  • Zhang SO, Trimble R, Guo F, Mak HY (2010) Lipid droplets as ubiquitous fat storage organelles in C. elegans. BMC Cell Biol 11:96

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We would like to thank all laboratory members for stimulating discussions and we apologize to those whose work has not been cited owing to space limitations. This work was supported by the Portuguese Foundation for Science and Technology (FCT) and FEDER (PTDC/SAU-OSM/103647/2008; PTDC/BIA-BCM/099613/2008; PTDC/BIA-BCM/118605/2010; SFRH/BPD/74428/2010 to M. I.) and BBSRC (BB/K006231/1).

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Authors and Affiliations

  1. College of Life and Environmental Sciences, Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK

    Michael Schrader

  2. Centre for Cell Biology & Department of Biology, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal

    Michael Schrader, Sandra Grille & Markus Islinger

  3. Department of Anatomy and Cell Biology, Division of Medical Cell Biology, University of Heidelberg, 69120, Heidelberg, Germany

    H. Dariush Fahimi

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  1. Michael Schrader
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  2. Sandra Grille
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  3. H. Dariush Fahimi
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  4. Markus Islinger
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Correspondence to Michael Schrader .

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  1. , Depto. Bioquímica, Biología Celular y, Estación Experimental del Zaidín, CSIC, Profesor Albareda 1, Granada, 18008, Spain

    Luis A. del Río

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Schrader, M., Grille, S., Fahimi, H.D., Islinger, M. (2013). Peroxisome Interactions and Cross-Talk with Other Subcellular Compartments in Animal Cells. In: del Río, L. (eds) Peroxisomes and their Key Role in Cellular Signaling and Metabolism. Subcellular Biochemistry, vol 69. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6889-5_1

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