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Transcriptional and Translational Regulation of Stem Cells pp 1–4Cite as

The Stem Cell State

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 786))

Abstract

This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

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Author information

Authors and Affiliations

  1. Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Melbourne, VIC, 3010, Australia

    Gary R. Hime

  2. Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia

    Helen E. Abud

Authors
  1. Gary R. Hime
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  2. Helen E. Abud
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Corresponding author

Correspondence to Gary R. Hime .

Editor information

Editors and Affiliations

  1. , Anatomy and Neuroscience, University of Melbourne, VIC Grattan Street, Parkville, 3010, Victoria, Australia

    Gary Hime

  2. , Anatomy and Developmental Biology, Monash University, Monash University, Clayton, 3800, Victoria, Australia

    Helen Abud

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Hime, G.R., Abud, H.E. (2013). The Stem Cell State. In: Hime, G., Abud, H. (eds) Transcriptional and Translational Regulation of Stem Cells. Advances in Experimental Medicine and Biology, vol 786. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6621-1_1

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