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Pollutants Biotransformation

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Abstract

All living organisms are exposed to large amounts of xenobiotics, many of which may be toxics. The presence of xenobiotics in a living organism can unbalance the living body by inhibiting its growth or interfering with one or more components or chemical reaction on which it is dependent. The sum of the processes by which a xenobiotic (pesticide) is subject to chemical changes in living organisms is named biotransformation. Biotransformation reactions (phase I or phase II) are important in understanding the metabolism of endogenous molecules (endobiotics), or of the exogenous ones (xenobiotics) and their purpose is to increase the protective mechanisms developed in relation to cells or biological fluids. The equilibrium among the concentration of parent pesticides, biotransformation intermediates and conjugates, is responsible for the cellular, tissue or organism toxicity.

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References

  1. Badea M, Florescu M, Coman G, Chesca A, Marty JL (2009) Comparative studies for pollutants detection using electrochemical sensors and enzyme-based biosensors. In: Vytas K, Kalcher K, Svancara I (eds) Sensing in electroanalysis. University Press, Pardubice

    Google Scholar 

  2. Beard J (2006) DDT and human health. Sci Total Environ 355:78–89

    Article  CAS  Google Scholar 

  3. Carozza SE, Li B, Wang Q, Horel S, Cooper S (2008) Agricultural pesticides and risk of childhood cancers. Int J Environ Health 212:186–195

    Article  Google Scholar 

  4. Coman G, Draghici C (2004) Pollutants and their impact on human body. Transilvania University Press, Brasov

    Google Scholar 

  5. Coman G, Draghici C, Chirila E, Sica M (2006) Pollutants effects on human body. In: Simeonov L, Chirila E (eds) Chemical as international and accidental global environmental threats. Springer, Dordrecht, pp 255–266

    Chapter  Google Scholar 

  6. Denisov IG, Frank DJ, Sligar SG (2009) Cooperative properties of cytochrome P450. Pharmacol Ther 124:151–167

    Article  CAS  Google Scholar 

  7. Dufol AF, Guillen SM (2009) Toxicogenomics and clinical toxicology. Toxicol Lett 186:2–8

    Article  Google Scholar 

  8. Ferrari A, Venturino A, Pechen AM (2007) Effects of carbaryl and azinphos methyl on juvenile rainbow trout detoxifying enzymes. Pestic Biochem Physiol 88:134–142

    Article  CAS  Google Scholar 

  9. Frova C (2006) Glutathione transferases in the genomics era. Biomol Eng 23:149–169

    Article  CAS  Google Scholar 

  10. Gonzales JF, Reimschuessel R, Shaikh B, Kane A (2009) Kinetic of hepatic phase I and II biotransformation reactions in eight finfish species. Mar Environ Res 67:183–188

    Article  Google Scholar 

  11. Hernandez AF, Parron T, Tsatsakis AM, Requena M, Alarcon R (2012) Toxic effects of pesticide mixtures at a molecular level. Toxicology (in press)

    Google Scholar 

  12. Kohle C, Bock KW (2007) Coordinate regulation of phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol 73:1853–1862

    Article  Google Scholar 

  13. Malekinejad H, Bakker RM, Gremmels JF (2006) Species differences in the hepatic biotransformation of zearalelone. Vet J 172:96–102

    Article  CAS  Google Scholar 

  14. Meijerman I, Beijnen JH, Schellens JHM (2008) Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer. Cancer Treat Rev 34:505–520

    Article  CAS  Google Scholar 

  15. Prade L, Huber R, Bieseler B (1998) Structurea in complex with their detoxifying enzyme glutathione S-transferase. Structure 6:1445–1452

    Article  CAS  Google Scholar 

  16. Sanchez LS, Roman R, Duhalt RV (2012) Pesticide transformation by a variant of CYPBM3 with improved peroxygenase activity. Pedstic Biochem Physiol 102:169–174

    Article  Google Scholar 

  17. Strazielle N, Khuth ST, Egea JFG (2004) Detoxification systems, passive and specific transport for drugs at the blood-CSF barrier in normal and pathological situations. Adv Drug Deliv Rev 56:1717–1740

    Article  CAS  Google Scholar 

  18. Tolson AH, Wang H (2010) Regulation of drug-metabolizing enzymes by xenobiotic receptors. Adv Drug Deliv Rev 62:1238–1249

    Article  CAS  Google Scholar 

  19. Vulimiri SV, Berger A, Sonawane B (2010) The potential metabolomic approaches for investigating mode of action of xenobiotics. Mutat Res 30:1–7

    Google Scholar 

  20. Zamek MJ, Hoffmaster KA, Nezasa K, Tallman MN, Brouwer KLR (2006) Integration of hepatic drug transporters and phase II metabolizing enzymes. Eur J Pharm Sci 27:447–486

    Article  Google Scholar 

  21. Zhang Q, Pi J, Woods CG, Andersen ME (2009) Phase I to II cross-induction of xenobiotics metabolizing enzymes. Toxicol Appl Pharmacol 237:345–356

    Article  CAS  Google Scholar 

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Correspondence to Gheorghe Coman .

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Matei, A.V., Farcas, A., Florian, C., Florescu, M., Coman, G. (2013). Pollutants Biotransformation. In: Simeonov, L., Macaev, F., Simeonova, B. (eds) Environmental Security Assessment and Management of Obsolete Pesticides in Southeast Europe. NATO Science for Peace and Security Series C: Environmental Security. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6461-3_9

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