Chapter

Role of Capsaicin in Oxidative Stress and Cancer

Volume 3 of the series Diet and Cancer pp 1-18

Date:

Role of Capsaicin in Cancer Prevention

  • Kartick C. PramanikAffiliated withDepartment of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center
  • , Sanjay K. SrivastavaAffiliated withDepartment of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center Email author 

Abstract

One of the aims of current cancer prevention research is to find non-toxic agents that can prevent and /or suppress the growth of cancer cells. In this regard, capsaicin, a main constituent of hot chili peppers, has garnered a great deal of attention as a chemo-preventive agent against cancer. In this book chapter capsaicin is discussed as a potent anti-cancer agent in different models, including pancreatic, prostate, lung, breast, colon, brain, hepatic, bladder, skin and stomach cancers. Investigators have shown that the anti-cancer effect of capsaicin results from modulation of key signaling molecules in major signaling pathways such as stress, cell cycle, mitochondrial dysfunction and ER-stress. Furthermore, capsaicin has proven effective in vivo in the animal models of various types of cancer. Overall findings on capsaicin suggest that capsaicin is a promising agent for the treatment of various types of cancer that nonetheless requires further clinical studies. This chapter focuses on the chemo-preventive efficacy of capsaicin in various types of cancer models.

Keywords

Capsaicin Chili peppers Cancer Apoptosis Stress signal Mitochondria In vitro and in vivo