Chapter

Role of Capsaicin in Oxidative Stress and Cancer

Volume 3 of the series Diet and Cancer pp 1-18

Date:

Role of Capsaicin in Cancer Prevention

  • Kartick C. PramanikAffiliated withDepartment of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center
  • , Sanjay K. SrivastavaAffiliated withDepartment of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center Email author 

* Final gross prices may vary according to local VAT.

Get Access

Abstract

One of the aims of current cancer prevention research is to find non-toxic agents that can prevent and /or suppress the growth of cancer cells. In this regard, capsaicin, a main constituent of hot chili peppers, has garnered a great deal of attention as a chemo-preventive agent against cancer. In this book chapter capsaicin is discussed as a potent anti-cancer agent in different models, including pancreatic, prostate, lung, breast, colon, brain, hepatic, bladder, skin and stomach cancers. Investigators have shown that the anti-cancer effect of capsaicin results from modulation of key signaling molecules in major signaling pathways such as stress, cell cycle, mitochondrial dysfunction and ER-stress. Furthermore, capsaicin has proven effective in vivo in the animal models of various types of cancer. Overall findings on capsaicin suggest that capsaicin is a promising agent for the treatment of various types of cancer that nonetheless requires further clinical studies. This chapter focuses on the chemo-preventive efficacy of capsaicin in various types of cancer models.

Keywords

Capsaicin Chili peppers Cancer Apoptosis Stress signal Mitochondria In vitro and in vivo