Abstract
The mTOR inhibitor rapamycin has received growing attention due to its immunosuppresive, antineoplastic and lifespan extending properties. The discovery of the drug and its target has had widespread implications for our understanding of the underlying metabolic processes in the cell. Indeed, rapamycin has opened up a new field of potential pharmacological targets. In the following chapter I will briefly review the molecular target of rapamycin and the current clinical applications for this compound.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS et al (2009) Nature 460:392–395
Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD et al (2010) Proc Natl Acad Sci U S A 107:4153–4158
Laplante M, Sabatini DM (2012) Cell 149:274–293
Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS et al (2012) Science 335:1638–1643
Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, Terracciano L, Heim MH, Ruegg MA, Hall MN (2012) Cell Metab 15:725–738
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM (2006) Mol Cell 22:159–168
Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN et al (2011) Cell 146:408–420
Toschi A, Lee E, Gadir N, Ohh M, Foster DA (2008) J Biol Chem 283:34495–34499
Chan EY (2009) Sci Signal 2:e51
Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME (2001) Mol Cell Biol 21:952–965
Chi H (2012) Nat Rev Immunol 12:325–338
Thomson AW, Turnquist HR, Raimondi G (2009) Nat Rev Immunol 9:324–337
Langone AJ, Helderman JH (2012) Chest 142:734–737
Fleg JL, Aronow WS, Frishman WH (2011) Nat Rev Cardiol 8:13–28
Castro C, Campistol JM, Sancho D, Sanchez-Madrid F, Casals E, Andres V (2004) Atherosclerosis 172:31–38
Elloso MM, Azrolan N, Sehgal SN, Hsu PL, Phiel KL, Kopec CA, Basso MD, Adelman SJ (2003) Am J Transplant 3:562–569
De LG, Dirksen MT, Spaulding C, Kelbaek H, Schalij M, Thuesen L, van der Hoeven B, Vink MA, Kaiser C, Musto C et al (2012) Arch Intern Med 172:611–621
Palmerini T, Biondi-Zoccai G, Della RD, Stettler C, Sangiorgi D, D’Ascenzo F, Kimura T, Briguori C, Sabate M, Kim HS et al (2012) Lancet 379:1393–1402
Bove J, Martinez-Vicente M, Vila M (2011) Nat Rev Neurosci 12:437–452
Modi PK, Komaravelli N, Singh N, Sharma P (2012) Mol Biol Cell 23:3722–3730
Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P, Wilson KA, Byars A, Sahmoud T, Franz DN (2010) N Engl J Med 363:1801–1811
Curatolo P, Jozwiak S, Nabbout R (2012) Eur J Paediatr Neurol 16:582–586
Cai Z, Zhao B, Li K, Zhang L, Li C, Quazi SH, Tan Y (2012) J Neurosci Res 90:1105–1118
Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del TD, Bentivoglio AR, Healy DG et al (2004) Science 304:1158–1160
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS et al (2010) Proc Natl Acad Sci U S A 107:378–383
Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S, Greene LA (2010) J Neurosci 30:1166–1175
Dello RC, Lisi L, Feinstein DL, Navarra P (2012) Glia [Epub ahead of print]
Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM, III, Cooper M, Spencer R, de CR et al (2012) J Exp Med 209:855–869
Acknowledgments
I would like to thank Dr. Vilhelm A. Bohr and Dr. Evandro Fei Fang for invaluable feedback and critically reading the manuscript. This research was supported entirely by the Intramural Research Program of the NIH, National Institute on Aging.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Scheibye-Knudsen, M. (2013). Rapamycin: Current and Future Uses. In: Fang, E., Ng, T. (eds) Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6214-5_16
Download citation
DOI: https://doi.org/10.1007/978-94-007-6214-5_16
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-6213-8
Online ISBN: 978-94-007-6214-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)