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Tetraspanins pp 169–186Cite as

Genetic Evidence for Tetraspanin Functions

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Part of the book series: Proteins and Cell Regulation ((PROR,volume 9))

Abstract

Tetraspanin proteins have been suggested to associate with many different cell surface partner proteins, and in vitro studies have suggested involvement in a wide variety of cellular functions. However, knockout phenotypes in mice have so far been relatively mild, and there have been few clear examples of human tetraspanin mutations having functional consequences. Nonetheless a range of sometimes subtle, but interesting phenotypes are emerging from studies of mouse knockouts, and from analysis of human mutations.

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  1. Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA, 02115, USA

    Martin E. Hemler

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Correspondence to Martin E. Hemler .

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  1. , School of Cancer Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, United Kingdom

    Fedor Berditchevski

  2. INSERM U1004, Av. Paul Vaillant Couturier 14, Villejuif, F-94807, France

    Eric Rubinstein

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Hemler, M.E. (2013). Genetic Evidence for Tetraspanin Functions. In: Berditchevski, F., Rubinstein, E. (eds) Tetraspanins. Proteins and Cell Regulation, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6070-7_7

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