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Cancer Predisposition in Diabetic Patients: Risk Assessment and Targeted Preventive Measures

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New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 3))

Abstract

Diabetes mellitus (DM) is a lifelong progressive disease with high morbidity and mortality worldwide, in particular due to severe complications secondary to metabolic disorders. Increasing evidence indicates that diabetic patients are highly predisposed to a spectrum of oncologic diseases. Understanding of molecular pathomechanisms of the cancer-provocation in DM is of great importance for the properly organised diabetes care. This chapter focuses on the epidemiology and cancer aetiology in DM and provides expert recommendations for the targeted prevention in the diabetic patient cohort.

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Abbreviations

DM:

Diabetes mellitus

DNA:

Deoxyribonucleic acid

ROS:

Reactive Oxygen Species

ETC:

Electron transfer chain

HPV:

human papilloma virus

CVD:

Cardiovascular Disease

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Authors and Affiliations

  1. Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, Bonn, D-53105, Germany

    Melanie Cebioglu, Hans H. Schild & Olga Golubnitschaja

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  1. Melanie Cebioglu
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  1. Dental Medicine, Oral Biology Faculty, Georgia Regents University, Laney Walker Blvd. 1459, Augusta, 30912, Georgia, USA

    Mahmood S. Mozaffari

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Cebioglu, M., Schild, H.H., Golubnitschaja, O. (2013). Cancer Predisposition in Diabetic Patients: Risk Assessment and Targeted Preventive Measures. In: Mozaffari, M. (eds) New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM. Advances in Predictive, Preventive and Personalised Medicine, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5971-8_13

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