Skip to main content
SpringerLink
Log in
Book cover

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future pp 31–44Cite as

Idiopathic REM Sleep Behavior Disorder as a Long-Term Predictor of Neurodegenerative Disorders

  • Chapter
  • First Online:

  • 956 Accesses

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 2))

Abstract

REM sleep behavior disorder (RBD) is a parasomnia characterized by dream-enacting behavior and loss of muscle atonia during REM sleep. Idiopathic RBD occurs in the absence of any neurological disease or other possible cause, is male-predominant and its clinical course is generally chronic progressive. Secondary RBD may be related to neurodegenerative disorders such as multiple system atrophy, Parkinson’s disease and Lewy body dementia. Recent long-term prospective studies have shown that 30–65% of patients with idiopathic RBD will eventually develop a neurodegenerative disorder with the rate of emergence depending on the length of the follow-up period. It may therefore be one of the earliest signs of and/or a long-term predictor for neurodegenerative disorders. Because RBD antecedes the development of these disorders by several years, its recognition may enable the delay or prevention of neurodegenerative disorders through the early application of neuroprotective or disease-modifying therapies in the future.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. American Academy of Sleep Medicine (2005) The international classification of sleep disorders: diagnostic and coding manual, 2nd edn. American Academy of Sleep Medicine, Westchester

    Google Scholar 

  2. Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW (1986) Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep 9:293–308

    PubMed  CAS  Google Scholar 

  3. Schenck CH, Lee SA, Bornemann MAC, Mahowald MW (2009) Potentially lethal behaviors associated with rapid eye movement sleep behavior disorder: review of the literature and forensic implications. J Forensic Sci 54:1475–1484

    Article  PubMed  Google Scholar 

  4. Gagnon J-F, Postuma RB, Montplaisir J (2006) Update on the pharmacology of REM sleep behavior disorder. Neurology 67:742–747

    Article  PubMed  Google Scholar 

  5. Aurora RN, Zak RS, Maganti RK, Auerbach SH, Casey KR, Chowdhuri S, Karippot A, Ramar K, Kristo DA, Morgenthaler TI; Standards of Practice Committee; American Academy of Sleep Medicine (2010) Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med 6:85–95

    PubMed  Google Scholar 

  6. Schuld A, Kraus T, Haack M, Hinze-Selch D, Pollmächer T (1999) Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. J Sleep Res 8:321–322

    Article  PubMed  CAS  Google Scholar 

  7. Boeve BF, Silber MH, Ferman TJ (2003) Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med 4:281–284

    Article  PubMed  Google Scholar 

  8. Kunz D, Bes F (1999) Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov Disord 14:507–511

    Article  PubMed  CAS  Google Scholar 

  9. Kunz D, Mahlberg R (2010) A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J Sleep Res 19:591–596

    Article  PubMed  Google Scholar 

  10. Iranzo A, Santamaria J, Tolosa E (2009) The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases. Sleep Med Rev 13:385–401

    Article  PubMed  Google Scholar 

  11. Hoque R, Chesson AL (2010) Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis. J Clin Sleep Med 6:79–83

    PubMed  Google Scholar 

  12. Morrison I, Frangulyan R, Riha RL (2011) Beta-blockers as a cause of violent rapid eye movement sleep behavior disorder: a poorly recognized but common cause of violent parasomnias. Am J Med 124:e11

    Article  PubMed  Google Scholar 

  13. Teman PT, Tippmann-Peikert M, Silber MH, Slocumb NL, Auger RR (2009) Idiopathic rapid-eye-movement sleep disorder: associations with antidepressants, psychiatric diagnoses, and other factors, in relation to age of onset. Sleep Med 10:60–65

    Article  PubMed  Google Scholar 

  14. Fantini ML, Postuma RB, Montplaisir J, Ferini-Strambi L (2006) Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder. Brain Res Bull 70:386–390

    Article  PubMed  Google Scholar 

  15. Miyamoto T, Miyamoto M, Iwanami M, Hirata K (2010) Olfactory dysfunction in Japanese patients with idiopathic REM sleep behavior disorder: comparison of data using the university of Pennsylvania smell identification test and odor stick identification test for Japanese. Mov Disord 25:1524–1526

    Article  PubMed  Google Scholar 

  16. Miyamoto T, Miyamoto M, Iwanami M, Hirata K, Kobayashi M, Nakamura M, Inoue Y (2010) Olfactory dysfunction in idiopathic REM sleep behavior disorder. Sleep Med 11:458–461

    Article  PubMed  Google Scholar 

  17. Miyamoto T, Miyamoto M, Iwanami M, Suzuki K, Inoue Y, Hirata K (2009) Odor identification test as an indicator of idiopathic REM sleep behavior disorder. Mov Disord 24:268–273

    Article  PubMed  Google Scholar 

  18. Stiasny-Kolster K, Clever S-C, Möller JC, Oertel WH, Mayer G (2007) Olfactory dysfunction in patients with narcolepsy with and without REM sleep behaviour disorder. Brain 130:442–449

    Article  PubMed  CAS  Google Scholar 

  19. Postuma RB, Lang AE, Massicotte-Marquez J, Montplaisir J (2006) Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Neurology 66:845–851

    Article  PubMed  CAS  Google Scholar 

  20. Ferini-Strambi L, Di Gioia MR, Castronovo V, Oldani A, Zucconi M, Cappa SF (2004) Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist? Neurology 62:41–45

    Article  PubMed  CAS  Google Scholar 

  21. Massicotte-Marquez J, Décary A, Gagnon J-F, Vendette M, Mathieu A, Postuma RB, Carrier J, Montplaisir J (2008) Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder. Neurology 70:1250–1257

    Article  PubMed  CAS  Google Scholar 

  22. Terzaghi M, Sinforiani E, Zucchella C, Zambrelli E, Pasotti C, Rustioni V, Manni R (2008) Cognitive performance in REM sleep behaviour disorder: a possible early marker of neurodegenerative disease? Sleep Med 9:343–351

    Article  PubMed  Google Scholar 

  23. Fantini ML, Gagnon J-F, Petit D, Rompré S, Décary A, Carrier J, Montplaisir J (2003) Slowing of electroencephalogram in rapid eye movement sleep behavior disorder. Ann Neurol 53:774–780

    Article  PubMed  Google Scholar 

  24. Iranzo A, Isetta V, Molinuevo JL, Serradell M, Navajas D, Farre R, Santamaria J (2011) Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder. Sleep Med 11:534–539

    Article  Google Scholar 

  25. Ferini-Strambi L, Oldani A, Zucconi M, Smirne S (1996) Cardiac autonomic activity during wakefulness and sleep in REM sleep behavior disorder. Sleep 19:367–369

    PubMed  CAS  Google Scholar 

  26. Lanfranchi PA, Fradette L, Gagnon J-F, Colombo R, Montplaisir J (2007) Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder. Sleep 30:1019–1025

    PubMed  Google Scholar 

  27. Postuma RB, Lanfranchi PA, Blais H, Gagnon J-F, Montplaisir JY (2010) Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder. Mov Disord 25:2304–2310

    Article  PubMed  Google Scholar 

  28. Kashihara K, Imamura T, Shinya T (2010) Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson’s disease. Parkinsonism Relat Disord 16:252–255

    Article  PubMed  Google Scholar 

  29. Miyamoto T, Miyamoto M, Inoue Y, Usui Y, Suzuki K, Hirata K (2006) Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Neurology 67:2236–2238

    Article  PubMed  CAS  Google Scholar 

  30. Miyamoto T, Miyamoto M, Iwanami M, Hirata K (2011) Cardiac (123)I-MIBG accumulation in Parkinson’s disease differs in association with REM sleep behavior disorder. Parkinsonism Relat Disord 17:219–220

    Article  PubMed  Google Scholar 

  31. Miyamoto T, Miyamoto M, Suzuki K, Nishibayashi M, Iwanami M, Hirata K (2008) 123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder. Sleep 31:717–723

    PubMed  Google Scholar 

  32. Eisensehr I, Linke R, Noachtar S, Schwarz J, Gildehaus FJ, Tatsch K (2000) Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson’s disease and controls. Brain 123:1155–1160

    Article  PubMed  Google Scholar 

  33. Iwanami M, Miyamoto T, Miyamoto M, Hirata K, Takada E (2010) Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. Sleep Med 11:361–365

    Article  PubMed  Google Scholar 

  34. Stockner H, Iranzo A, Seppi K, Serradell M, Gschliesser V, Sojer M, Valldeoriola F, Molinuevo JL, Frauscher B, Schmidauer C, Santamaria J, Högl B, Tolosa E, Poewe W; SINBAR (Sleep Innsbruck Barcelona) Group (2009) Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder. Mov Disord 24:1906–1909

    Article  PubMed  Google Scholar 

  35. Unger MM, Möller JC, Stiasny-Kolster K, Mankel K, Berg D, Walter U, Hoeffken H, Mayer G, Oertel WH (2008) Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT. Mov Disord 23:596–599

    Article  PubMed  Google Scholar 

  36. Plazzi G, Corsini R, Provini F, Pierangeli G, Martinelli P, Montagna P, Lugaresi E, Cortelli P (1997) REM sleep behavior disorders in multiple system atrophy. Neurology 48:1094–1097

    Article  PubMed  CAS  Google Scholar 

  37. Tachibana N, Kimura K, Kitajima K, Shinde A, Kimura J, Shibasaki H (1997) REM sleep motor dysfunction in multiple system atrophy: with special emphasis on sleep talk as its early clinical manifestation. J Neurol Neurosurg Psychiatr 63:678–681

    Article  PubMed  CAS  Google Scholar 

  38. Iranzo A, Santamaría J, Rye DB, Valldeoriola F, Martí MJ, Muñoz E, Vilaseca I, Tolosa E (2005) Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. Neurology 65:247–252

    Article  PubMed  CAS  Google Scholar 

  39. Köllensperger M, Geser F, Seppi K, Stampfer-Kountchev M, Sawires M, Scherfler C, Boesch S, Mueller J, Koukouni V, Quinn N, Pellecchia MT, Barone P, Schimke N, Dodel R, Oertel W, Dupont E, Østergaard K, Daniels C, Deuschl G, Gurevich T, Giladi N, Coelho M, Sampaio C, Nilsson C, Widner H, Sorbo FD, Albanese A, Cardozo A, Tolosa E, Abele M, Klockgether T, Kamm C, Gasser T, Djaldetti R, Colosimo C, Meco G, Schrag A, Poewe W, Wenning GK; European MSA Study Group (2008) Red flags for multiple system atrophy. Mov Disord 23:1093–1099

    Article  PubMed  Google Scholar 

  40. Vetrugno R, Provini F, Cortelli P, Plazzi G, Lotti EM, Pierangeli G, Canali C, Montagna P (2004) Sleep disorders in multiple system atrophy: a correlative video-polysomnographic study. Sleep Med 5:21–30

    Article  PubMed  Google Scholar 

  41. Olson EJ, Boeve BF, Silber MH (2000) Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain 123:331–339

    Article  PubMed  Google Scholar 

  42. Gagnon JF, Bédard MA, Fantini ML, Petit D, Panisset M, Rompré S, Carrier J, Montplaisir J (2002) REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease. Neurology 59:585–589

    Article  PubMed  CAS  Google Scholar 

  43. De Cock VC, Vidailhet M, Leu S, Texeira A, Apartis E, Elbaz A, Roze E, Willer JC, Derenne JP, Agid Y, Arnulf I (2007) Restoration of normal motor control in Parkinson’s disease during REM sleep. Brain 130:450–456

    Article  PubMed  Google Scholar 

  44. Wetter TC, Trenkwalder C, Gershanik O, Högl B (2001) Polysomnographic measures in Parkinson’s disease: a comparison between patients with and without REM sleep disturbances. Wien Klin Wochenschr 113:249–253

    PubMed  CAS  Google Scholar 

  45. Diederich NJ, Vaillant M, Mancuso G, Lyen P, Tiete J (2005) Progressive sleep “destructuring” in Parkinson’s disease. A polysomnographic study in 46 patients. Sleep Med 6:313–318

    Article  PubMed  Google Scholar 

  46. Kumru H, Santamaria J, Tolosa E, Iranzo A (2007) Relation between subtype of Parkinson’s disease and REM sleep behavior disorder. Sleep Med 8:779–783

    Article  PubMed  Google Scholar 

  47. Boeve BF, Silber MH, Ferman TJ, Lucas JA, Parisi JE (2001) Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord 16(4):622–630

    Article  PubMed  CAS  Google Scholar 

  48. Ferman TJ, Smith GE, Boeve BF, Ivnik RJ, Petersen RC, Knopman D, Graff-Radford N, Parisi J, Dickson DW (2004) DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology 62:181–187

    Article  PubMed  CAS  Google Scholar 

  49. Boeve BF, Silber MH, Ferman TJ, Kokmen E, Smith GE, Ivnik RJ, Parisi JE, Olson EJ, Petersen RC (1998) REM sleep behavior disorder and degenerative dementia: an association likely reflecting lewy body disease. Neurology 51:363–370

    Article  PubMed  CAS  Google Scholar 

  50. Ferman TJ, Boeve BF, Smith GE, Silber MH, Kokmen E, Petersen RC, Ivnik RJ (1999) REM sleep behavior disorder and dementia: cognitive differences when compared with AD. Neurology 52:951–957

    Article  PubMed  CAS  Google Scholar 

  51. Boeve BF, Silber MH, Parisi JE, Dickson DW, Ferman TJ, Benarroch EE, Schmeichel AM, Smith GE, Petersen RC, Ahlskog JE, Matsumoto JY, Knopman DS, Schenck CH, Mahowald MW (2003) Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 61:40–45

    Article  PubMed  CAS  Google Scholar 

  52. Kumru H, Santamaria J, Tolosa E, Valldeoriola F, Muñoz E, Marti MJ, Iranzo A (2004) Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations. Ann Neurol 56:599–603

    Article  PubMed  CAS  Google Scholar 

  53. Postuma RB, Gagnon JF, Vendette M, Charland K, Montplaisir J (2008) REM sleep behaviour disorder in Parkinson’s disease is associated with specific motor features. J Neurol Neurosurg Psychiatr 79:1117–1121

    Article  PubMed  CAS  Google Scholar 

  54. Gagnon J-F, Fantini ML, Bédard M-A, Petit D, Carrier J, Rompré S, Décary A, Panisset M, Montplaisir J (2004) Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia. Neurology 62:401–406

    Article  PubMed  Google Scholar 

  55. Vendette M, Gagnon J-F, Décary A, Massicotte-Marquez J, Postuma RB, Doyon J, Panisset M, Montplaisir J (2007) REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. Neurology 69:1843–1849

    Article  PubMed  CAS  Google Scholar 

  56. Iranzo A, Molinuevo JL, Santamaría J, Serradell M, Martí MJ, Valldeoriola F, Tolosa E (2006) Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol 5:572–577

    Article  PubMed  Google Scholar 

  57. McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M; Consortium on DLB (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology 65:1863–1872

    Article  PubMed  CAS  Google Scholar 

  58. Sforza E, Krieger J, Petiau C (1997) REM sleep behavior disorder: clinical and physiopathological findings. Sleep Med Rev 1:57–69

    Article  PubMed  CAS  Google Scholar 

  59. Weyer A, Minnerop M, Abele M, Klockgether T (2006) REM sleep behavioral disorder in pure autonomic failure (PAF). Neurology 66:608–609

    Article  PubMed  Google Scholar 

  60. Arnulf I, Merino-Andreu M, Bloch F, Konofal E, Vidailhet M, Cochen V, Derenne JP, Agid Y (2005) REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. Sleep 28:349–354

    PubMed  Google Scholar 

  61. Gagnon J-F, Petit D, Fantini ML, Rompré S, Gauthier S, Panisset M, Robillard A, Montplaisir J (2006) REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease. Sleep 29:1321–1325

    PubMed  Google Scholar 

  62. Boeve BF, Lin S-C, Strongosky A, Dickson DW, Wszolek ZK (2006) Absence of rapid eye movement sleep behavior disorder in 11 members of the pallidopontonigral degeneration kindred. Arch Neurol 63:268–272

    Article  PubMed  Google Scholar 

  63. Gagnon J-F, Postuma RB, Mazza S, Doyon J, Montplaisir J (2006) Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol 5:424–432

    Article  PubMed  Google Scholar 

  64. Dauvilliers Y, Rompré S, Gagnon J-F, Vendette M, Petit D, Montplaisir J (2007) REM sleep characteristics in narcolepsy and REM sleep behavior disorder. Sleep 30:844–849

    PubMed  Google Scholar 

  65. Mayer M-E (1993) Motor dyscontrol in sleep of narcoleptic patients (a lifelong development?). J Sleep Res 2:143–148

    Article  PubMed  Google Scholar 

  66. Nightingale S, Orgill JC, Ebrahim IO, de Lacy SF, Agrawal S, Williams AJ (2005) The association between narcolepsy and REM behavior disorder (RBD). Sleep Med 6:253–258

    Article  PubMed  CAS  Google Scholar 

  67. Schenck CH, Mahowald MW (1992) Motor dyscontrol in narcolepsy: rapid-eye-movement (REM) sleep without atonia and REM sleep behavior disorder. Ann Neurol 32:3–10

    Article  PubMed  CAS  Google Scholar 

  68. Iranzo A, Graus F, Clover L, Morera J, Bruna J, Vilar C, Martínez-Rodriguez JE, Vincent A, Santamaría J (2006) Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis. Ann Neurol 59:178–181

    Article  PubMed  Google Scholar 

  69. Cochen V, Arnulf I, Demeret S, Neulat ML, Gourlet V, Drouot X, Moutereau S, Derenne JP, Similowski T, Willer JC, Pierrot-Deseiligny C, Bolgert F (2005) Vivid dreams, hallucinations, psychosis and REM sleep in Guillain-Barré syndrome. Brain 128:2535–2545

    Article  PubMed  CAS  Google Scholar 

  70. Tan A, Salgado M, Fahn S (1996) Rapid eye movement sleep behavior disorder preceding Parkinson’s disease with therapeutic response to levodopa. Mov Disord 11:214–216

    Article  PubMed  CAS  Google Scholar 

  71. Uchiyama M, Isse K, Tanaka K, Yokota N, Hamamoto M, Aida S, Ito Y, Yoshimura M, Okawa M (1995) Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology 45:709–712

    Article  PubMed  CAS  Google Scholar 

  72. Turner RS, D’Amato CJ, Chervin RD, Blaivas M (2000) The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. Neurology 55:1730–1732

    Article  PubMed  CAS  Google Scholar 

  73. Tison F, Wenning GK, Quinn NP, Smith SJ (1995) REM sleep behaviour disorder as the presenting symptom of multiple system atrophy. J Neurol Neurosurg Psychiatry 58:379–380

    Article  PubMed  CAS  Google Scholar 

  74. Schenck CH, Mahowald MW, Anderson ML, Silber MH, Boeve BF, Parisi JE (1997) Lewy body variant of Alzheimer’s disease (AD) identified by postmortem ubiquitin staining in a previously reported case of AD associated with REM sleep behavior disorder. Biol Psychiatry 42:527–528

    Article  PubMed  CAS  Google Scholar 

  75. Wright BA, Rosen JR, Buysse DJ, Reynolds CF, Zubenko GS (1990) Shy-Drager syndrome presenting as a REM behavioral disorder. J Geriatr Psychiatry Neurol 3:110–113

    Article  PubMed  CAS  Google Scholar 

  76. Claassen DO, Josephs KA, Ahlskog JE, Silber MH, Tippmann-Peikert M, Boeve BF (2010) REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology 75:494–499

    Article  PubMed  CAS  Google Scholar 

  77. Boeve BF, Dickson DW, Olson EJ, Shepard JW, Silber MH, Ferman TJ, Ahlskog JE, Benarroch EE (2007) Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep Med 8(1):60–64

    Article  PubMed  CAS  Google Scholar 

  78. Schenck CH, Bundlie SR, Mahowald MW (1996) Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder. Neurology 46:388–393

    Article  PubMed  CAS  Google Scholar 

  79. Schenck CH, Bundlie SR, Mahowald MW (2003) REM sleep behaviour disorder (RBD) delayed emergence of parkinsonism and/or dementia in 65% of older men initially diagnosed with idiopathic RBD, and an analysis of the maximum and minimum tonic and/or phasic electromyographic abnormalities found during REM sleep. Sleep 26(Abstract Suppl):A316

    Google Scholar 

  80. Tippman-Peikert M, Olson EJ, Boeve B, Silber MH (2006) Idiopathic REM sleep behavior disorder: a follow-up of 39 patients. Sleep 29:A272

    Google Scholar 

  81. Iranzo A, Molinuevo J, Santamaria J, Serradell M, Marti M, Valledeoriola F, Tolosa E (2008) Sixty-four percent of patients with idiopathic REM sleep behavior disorder developed a neurological disorder after a mean clinical follow-up of seven years. Sleep 31:A280

    Google Scholar 

  82. Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J (2009) Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 72:1296–1300

    PubMed  CAS  Google Scholar 

  83. Iranzo A, Ratti PL, Casanova-Molla J, Serradell M, Vilaseca I, Santamaria J (2009) Excessive muscle activity increases over time in idiopathic REM sleep behavior disorder. Sleep 32:1149–1153

    PubMed  Google Scholar 

  84. Fantini ML, Farini E, Ortelli P, Zucconi M, Manconi M, Cappa S, Ferini-Strambi L (2011) Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. Sleep 34:619–625

    PubMed  Google Scholar 

  85. Miyamoto T, Orimo S, Miyamoto M, Hirata K, Adachi T, Hattori R, Suzuki M, Ishii K (2010) Follow-up PET studies in case of idiopathic REM sleep behavior disorder. Sleep Med 11: 100–101

    Article  PubMed  Google Scholar 

  86. Iranzo A, Lomeña F, Stockner H, Valldeoriola F, Vilaseca I, Salamero M, Molinuevo JL, Serradell M, Duch J, Pavía J, Gallego J, Seppi K, Högl B, Tolosa E, Poewe W, Santamaria J; Sleep Innsbruck Barcelona (SINBAR) group (2010) Decreased striatal dopamine transporters uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol 9:1070–1077

    Article  PubMed  CAS  Google Scholar 

  87. Postuma RB, Gagnon JF, Rompré S, Montplaisir JY (2010) Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease. Neurology 74:239–244

    Article  PubMed  CAS  Google Scholar 

  88. Postuma RB, Gagnon J-F, Vendette M, Desjardins C, Montplaisir JY (2011) Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder. Ann Neurol 69:811–818

    Article  PubMed  Google Scholar 

  89. Ahlskog JE (2007) Beating a dead horse: dopamine and Parkinson disease. Neurology 69:1701–1711

    Article  PubMed  CAS  Google Scholar 

  90. Savica R, Rocca WA, Ahlskog JE (2010) When does Parkinson disease start? Arch Neurol 67:798–801

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland

    Stephany Fulda & Mauro Manconi

Authors
  1. Stephany Fulda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mauro Manconi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephany Fulda .

Editor information

Editors and Affiliations

  1. , Molecular Pharmacology, Technion, Institute of Technology, Efron, Haifa, 31096, Israel

    Silvia Mandel

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Fulda, S., Manconi, M. (2013). Idiopathic REM Sleep Behavior Disorder as a Long-Term Predictor of Neurodegenerative Disorders. In: Mandel, S. (eds) Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future. Advances in Predictive, Preventive and Personalised Medicine, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5866-7_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-5866-7_3

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-5865-0

  • Online ISBN: 978-94-007-5866-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation