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Proteomics in Anaesthesia and Intensive Care Medicine

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Book cover Bioinformatics of Human Proteomics

Part of the book series: Translational Bioinformatics ((TRBIO,volume 3))

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Abstract

Proteomics is a systems-based methodology for describing the changes in protein expression present in biological samples that can occur with disease processes. Analysis of proteome allows individuating proteins that act as biomarkers, which have many potential roles in clinical practice: diagnosis, response to treatment, risk stratification and prognosis. This chapter summarises the most important proteomics application in anaesthesiology and critical care.

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References

  • Alzate O, Hussain SR, Goettl VM, Tewari AK, Madiai F, Stephens Jr RL, et al. Proteomic identification of brainstem cytosolic proteins in a neuropathic pain model. Brain Res Mol Brain Res. 2004;128:193–200.

    Article  PubMed  CAS  Google Scholar 

  • Atkins JH, Johansson JS. Technologies to shape the future: proteomics applications in anesthesiology and critical care medicine. Anesth Analg. 2006;102(4):1207–16.

    Article  PubMed  CAS  Google Scholar 

  • Attal N. Neuropathic pain: mechanisms, therapeutic approach, and interpretation of clinical trials. Continuum (Minneap Minn). 2012;18(1):161–75.

    Google Scholar 

  • Barnett N, Ware LB. Biomarkers in acute lung injury–marking forward progress. Crit Care Clin. 2011;27(3):661–83.

    Article  PubMed  CAS  Google Scholar 

  • Bhattacharya AA, Curry S, Franks NP. Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J Biol Chem. 2000;275(49):38731–8.

    Article  PubMed  CAS  Google Scholar 

  • Cadosch D, Thyer M, Gautschi OP, Lochnit G, Frey SP, Zellweger R, Filgueira L, Skirving AP. Functional and proteomic analysis of serum and cerebrospinal fluid derived from patients with traumatic brain injury: a pilot study. ANZ J Surg. 2010;80(7–8):542–7.

    Article  PubMed  Google Scholar 

  • Chang DW, Hayashi S, Gharib SA, Vaisar T, King ST, Tsuchiya M, Ruzinski JT, Park DR, et al. Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2008;178(7):701–9.

    Article  PubMed  CAS  Google Scholar 

  • Decarlo K, Emley A, Dadzie OE, Mahalingam M. Laser capture microdissection: methods and applications. Method Mol Biol. 2011;755:1–15.

    Article  CAS  Google Scholar 

  • Duan K, Ouyang W, Chen M, Xia Y, Wang S. Delayed effect of isoflurane on hippocampal proteome after anesthesia in adult and aged rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34(7):589–94.

    PubMed  CAS  Google Scholar 

  • Eckenhoff RG, Johansson JS. Molecular interactions between inhaled anesthetics and proteins. Pharmacol Rev. 1997;49(4):343–67.

    PubMed  CAS  Google Scholar 

  • Feng J, Zhu M, Schaub MC, Gehrig P, Roschitzki B, Lucchinetti E, et al. Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function. Cardiovasc Res. 2008;80(1):20–9.

    Article  PubMed  CAS  Google Scholar 

  • Finnerup NB, Baastrup C. Spinal cord injury pain: mechanisms and management. Curr Pain Headache Rep. 2012;16(3):207–16.

    Article  PubMed  Google Scholar 

  • Franks NP. Molecular targets underlying general anaesthesia. Br J Pharmacol. 2006;147 Suppl 1:S72–81.

    PubMed  CAS  Google Scholar 

  • Fütterer CD, Maurer MH, Schmitt A, Feldmann Jr RE, Kuschinsky W, Waschke KF. Alterations in rat brain proteins after desflurane anesthesia. Anesthesiology. 2004;100(2):302–8.

    Article  PubMed  Google Scholar 

  • Gong Y, Chen N, Wang FQ, Wang ZH, Xu HX. Serum proteome alteration of severe sepsis in the treatment of continuous renal replacement therapy. Nephrol Dial Transplant. 2009;24(10):3108–14.

    Article  PubMed  CAS  Google Scholar 

  • Gordh T, Chu H, Sharma HS. Spinal nerve lesion alters blood-spinal cord barrier function and activates astrocytes in the rat. Pain. 2006;124(1–2):211–21.

    Article  PubMed  Google Scholar 

  • Hergenroeder G, Redell JB, Moore AN, Dubinsky WP, Funk RT, Crommett J, Clifton GL, Levine R, Valadka A, Dash PK. Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressure. J Neurotrauma. 2008;25(2):79–93.

    Article  PubMed  Google Scholar 

  • Hirota K, Takabuchi S, Namba T, Fukuda K. Halothane reversibly blocks cellular hypoxic responses mediated by Hypoxia-Inducible Factor 1. Anesthesiology. 2003;99:A88.

    Google Scholar 

  • Kalenka A, Feldmann Jr RE, Otero K, Maurer MH, Aschke KF, Fiedler F. Changes in the serum proteome of patients with sepsis and septic shock. Anesth Analg. 2006;103(6):1522–6.

    Article  PubMed  CAS  Google Scholar 

  • Kalenka A, Hinkelbein J, Feldmann Jr RE, Kuschinsky W, Waschke KF, Maurer MH. The effects of sevoflurane anesthesia on rat brain proteins: a proteomic time-course analysis. Anesth Analg. 2007;104(5):1129–35.

    Article  PubMed  CAS  Google Scholar 

  • Kalenka A, Gross B, Maurer MH, Thierse HJ, Feldmann Jr RE. Isoflurane anesthesia elicits protein pattern changes in rat hippocampus. J Neurosurg Anesthesiol. 2010;22(2):144–54.

    Article  PubMed  Google Scholar 

  • Kamagata C, Tsuboko Y, Okabe T, Sato C, Sakamoto A. Proteomic analysis of rat brains in a model of neuropathic pain following exposure to electroconvulsive stimulation. Biomed Res. 2011;32(2):91–102.

    Article  PubMed  CAS  Google Scholar 

  • Kang SK, So HH, Moon YS, Kim CH. Proteomic analysis of injured spinal cord tissue proteins using 2-DE and MALDI-TOF MS. Proteomics. 2006;6(9):2797–812.

    Article  PubMed  CAS  Google Scholar 

  • Katano T, Mabuchi T, Okuda-Ashitaka E, Inagaki N, Kinumi T, Ito S. Proteomic identification of a novel isoform of collapsin response mediator protein-2 in spinal nerves peripheral to dorsal root ganglia. Proteomics. 2006;6(22):6085–94.

    Article  PubMed  CAS  Google Scholar 

  • Ketola RA, Mauriala T. Mass spectrometric tools for cell and tissue studies. Eur J Pharm Sci. 2012;46(5):293–314.

    Article  PubMed  CAS  Google Scholar 

  • Koch C, Greenfield S. How does consciousness happen? Sci Am. 2007;297(4):76–83.

    Article  PubMed  Google Scholar 

  • Kopp Lugli A, Yost CS, Kindler CH. Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia. Eur J Anaesthesiol. 2009;26(10):807–20.

    Article  PubMed  Google Scholar 

  • Kühlein HN, Tegeder I, Möser C, Lim HY, Häussler A, Spieth K, et al. Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain. PLoS One. 2011;6(4):e19270.

    Article  PubMed  Google Scholar 

  • Kunz S, Tegeder I, Coste O, Marian C, Pfenninger A, Corvey C, et al. Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models. Neurosci Lett. 2005;381(3):289–93.

    Article  PubMed  CAS  Google Scholar 

  • Lee SC, Yoon TG, Yoo YI, Bang YJ, Kim HY, Jeoung DI, et al. Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal nerve injury. Biotechnol Lett. 2003;25(24):2071–8.

    Article  PubMed  CAS  Google Scholar 

  • Lee SH, Kim SY, Kim JH, Jung HY, Moon JH, Bae KH, et al. Phosphoproteomic analysis of electroacupuncture analgesia in an inflammatory pain rat model. Mol Med Rep. 2012;6(1):157–62.

    PubMed  CAS  Google Scholar 

  • Li WJ, Pan SQ, Zeng YS, Su BG, Li SM, Ding Y, et al. Identification of acupuncture-specific proteins in the process of electro-acupuncture after spinal cord injury. Neurosci Res. 2010;67(4):307–16.

    Article  PubMed  CAS  Google Scholar 

  • Lu J, Katano T, Nishimura W, Fujiwara S, Miyazaki S, Okasaki I, et al. Proteomic analysis of cerebrospinal fluid before and after intrathecal injection of steroid into patients with postherpetic pain. Proteomics. 2012. doi:10.1002/pmic.201200125.

  • Modesti PA, Gamberi T, Bazzini C, Borro M, Romano SM, Cambi GE, et al. Response of serum proteome in patients undergoing infrarenal aortic aneurysm repair. Anesthesiology. 2009;111(4):844–54.

    Article  PubMed  Google Scholar 

  • Monroe EB, Annangudi SP, Hatcher NG, Gustein HB, Rubakhin SS, Sweedler JV. SIMS and MALDI MS imaging of the spinal cord. Proteomics. 2008;8(18):3746–54.

    Article  PubMed  CAS  Google Scholar 

  • Moore E, Bellomo R, Nichol A. Biomarkers of acute kidney injury in anesthesia, intensive care and major surgery: from the bench to clinical research to clinical practice. Minerva Anestesiol. 2010;76(6):425–40.

    PubMed  CAS  Google Scholar 

  • Morgan PG, Hoppel CL, Sedensky MM. Mitochondrial defects and anesthetic sensitivity. Anesthesiology. 2002;96(5):1268–70.

    Article  PubMed  Google Scholar 

  • Niederberger E, Geisslinger G. Proteomics in neuropathic pain research. Anesthesiology. 2008;108(2):314–23.

    Article  PubMed  CAS  Google Scholar 

  • Oki G, Wada T, Iba K, Aiki H, Sasaki K, Imai S, Sohma H, Matsumoto K, Yamaguchi M, Fujimiya M, Yamashita T, Kokai Y. Metallothionein deficiency in the injured peripheral nerves of complex regional pain syndrome as revealed by proteomics. Pain. 2012;153(3):532–9.

    Article  PubMed  CAS  Google Scholar 

  • Pan JZ, Xi J, Tobias JW, Eckenhoff MF, Eckenhoff RG. Halothane binding proteome in human brain cortex. J Proteome Res. 2007;6(2):582–92.

    Article  PubMed  CAS  Google Scholar 

  • Pan JZ, Xi J, Eckenhoff MF, Eckenhoff RG. Inhaled anesthetics elicit region-specific changes in protein expression in mammalian brain. Proteomics. 2008;8(14):2983–92.

    Article  PubMed  CAS  Google Scholar 

  • Piazza O, Cotena S, De Robertis E, Caranci F, Tufano R. Sepsis associated encephalopathy studied by MRI and cerebral spinal fluid S100B measurement. Neurochem Res. 2009;34(7):1289–92.

    Article  PubMed  CAS  Google Scholar 

  • Piazza O, Pulcrano G, Fiori PL, Tufano R, Lonardo M, Rossano F, Catania MR. Toll-like receptor kinetics in septic shock patients: a preliminary study. Int J Immunopathol Pharmacol. 2012;25(2):425–33.

    PubMed  CAS  Google Scholar 

  • Pidikiti R, Zhang T, Mallela KM, Shamim M, Reddy KS, Johansson JS. Sevoflurane-induced structural changes in a four-alpha-helix bundle protein. Biochemistry. 2005;44(36):12128–35.

    Article  PubMed  CAS  Google Scholar 

  • Sharma HS, Gordh T, Wiklund L, Mohanty S, Sjoquist PO. Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51: an experimental study using light and electron microscopy in the rat. J Neural Transm. 2006;113(4):521–36.

    Article  PubMed  CAS  Google Scholar 

  • Shui HA, Ho ST, Wang JJ, Wu CC, Lin CH, Tao YX, et al. Proteomic analysis of spinal protein expression in rats exposed to repeated intrathecal morphine injection. Proteomics. 2007;7(5):796–803.

    Article  PubMed  CAS  Google Scholar 

  • Singh OV, Tao YX. Two-dimensional gel electrophoresis: discovering neuropathic pain-associated synaptic biomarkers in spinal cord dorsal horn. Method Mol Biol. 2012;851:47–63.

    Article  CAS  Google Scholar 

  • Song Z, Guo Q, Zhang J, Li M, Liu C, Zou W. Proteomic analysis of PKCγ-related proteins in the spinal cord of morphine-tolerant rats. PLoS One. 2012;7(7):e42068.

    Article  PubMed  CAS  Google Scholar 

  • Tang J, Chen X, Tu W, Guo Y, Zhao Z, Xue Q, et al. Propofol inhibits the activation of p38 through up-regulating the expression of annexin A1 to exert its anti-inflammation effect. PLoS One. 2011;6(12):e27890.

    Article  PubMed  CAS  Google Scholar 

  • Tsuboko Y, Sakamoto A. Propofol anaesthesia alters the cerebral proteome differently from sevoflurane anaesthesia. Biomed Res. 2011;32(1):55–65.

    Article  PubMed  CAS  Google Scholar 

  • Vemparala S, Domene C, Klein ML. Computational studies on the interactions of inhalational anesthetics with proteins. Acc Chem Res. 2010;43(1):103–10.

    Article  PubMed  CAS  Google Scholar 

  • Vlek AL, Bonten MJ, Boel CH. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia. PLoS One. 2012;7(3):e32589.

    Article  PubMed  CAS  Google Scholar 

  • WHO International Programme on Chemical Safety. Biomarkers in risk assessment: validity and validation. 2001. http://www.inchem.org/documents/ehc/ehc/ehc222.htm

  • Xi J, Liu R, Asbury GR, Eckenhoff MF, Eckenhoff RG. Inhalational anesthetic-binding proteins in rat neuronal membranes. J Biol Chem. 2004;279(19):19628–33.

    Article  PubMed  CAS  Google Scholar 

  • Xiao YY, Chang YT, Ran K, Liu JP. Delayed preconditioning by sevoflurane elicits changes in the mitochondrial proteome in ischemia-reperfused rat hearts. Anesth Analg. 2011;113(2):224–32.

    Article  PubMed  CAS  Google Scholar 

  • Xu B, Descalzi G, Ye HR, Zhuo M, Wang YW. Translational investigation and treatment of neuropathic pain. Mol Pain. 2012;8:15.

    Article  PubMed  CAS  Google Scholar 

  • Zhang X, Liu Y, Feng C, Yang S, Wang Y, Wu AS, et al. Proteomic profiling of the insoluble fractions in the rat hippocampus post-propofol anesthesia. Neurosci Lett. 2009;465(2):165–70.

    Article  PubMed  CAS  Google Scholar 

  • Zhang Q, Li SZ, Feng CS, Qu XD, Wang H, Zhang XN, et al. Serum proteomics of early postoperative cognitive dysfunction in elderly patients. Chin Med J (Engl). 2012;125(14):2455–61.

    CAS  Google Scholar 

  • Zou W, Zhan X, Li M, Song Z, Liu C, Peng F, et al. Identification of differentially expressed proteins in the spinal cord of neuropathic pain models with PKCgamma silence by proteomic analysis. Brain Res. 2012;1440:34–46.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine and Surgery, Università di Salerno, Salerno, Italy

    Ornella Piazza M.D.

  2. Department of Anesthesia and Intensive Care Medicine, Università di Napoli Federico II, Naples, Italy

    Giuseppe De Benedictis M.D. & Geremia F. Zito Marinosci M.D.

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  1. Ornella Piazza M.D.
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  2. Giuseppe De Benedictis M.D.
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  3. Geremia F. Zito Marinosci M.D.
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Correspondence to Ornella Piazza M.D. .

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Editors and Affiliations

  1. , Medicine, Biomedical Research Center, Fudan University Zhongshan Hospital, Shang Hai, China, People's Republic

    Xiangdong Wang

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Piazza, O., De Benedictis, G., Marinosci, G.F.Z. (2013). Proteomics in Anaesthesia and Intensive Care Medicine. In: Wang, X. (eds) Bioinformatics of Human Proteomics. Translational Bioinformatics, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5811-7_16

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