Abstract
The vasculature within the normal brain is structurally unique compared to blood vessels found throughout the rest of the body. This unique structure highly regulates which molecules and or drugs can enter into brain tissue. However, when a brain metastasis is formed, the vasculature becomes compromised, and as a result is much more permissive in allowing molecules and or drugs to move from the blood into the brain metastasis. Quantifying these changes allow significant insight into the ability of chemotherapeutics to penetrate into a brain metastasis. Herein, we discuss the vascular structural changes that are present within a brain metastasis, clinical and preclinical differences between observed permeability in a primary tumor and a metastasis, and lastly the most common methods to determine permeability changes within a central lesion.
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Adkins, C.E., Mittapalli, R.K., Bohn, K.A., Bansal, A., Venishetty, V.K., Lockman, P.R. (2012). Vascular Permeability Within Brain Metastases. In: Palmieri, D. (eds) Central Nervous System Metastasis, the Biological Basis and Clinical Considerations. Cancer Metastasis - Biology and Treatment, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5291-7_4
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DOI: https://doi.org/10.1007/978-94-007-5291-7_4
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