Abstract
A personal account of the invention, growth and commercialization of Electric Cell-substrate Impedance Sensing (ECIS) by the inventors of the technology. From the first experiments at the General Electric Research and Development Center in the early 1980s to the outgrowth of applications and finally the incorporation of Applied BioPhysics, Inc., the chapter provides an historical and often amusing account of the evolution of ECIS.
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Campbell CE, Motzfeldt-Laane M, Haugarvoll E, Giaever I (2007) Monitoring viral induced cell death using electric cell-substrate impedance sensing. Biosens Bioelectron 23(4):536–542
Giaever I, Keese CR (1984) Monitoring fibroblast behavior in tissue culture with an applied electric field. Proc Natl Acad Sci USA 81:3761–3764
Giaever I, Keese CR (1986) Use of electric fields to monitor the dynamical aspect of cell behavior in tissue culture. IEEE Trans Biomed Eng BME-33:242–247
Giaever I, Keese CR (1991) Micromotion of mammalian cells measured electrically. Proc Natl Acad Sci USA 88:7896–7900
Keese CR, Giaever I (1983) Cell growth on liquid microcarriers. Science 219:1448–1449
Keese CR, Bhawe K, Wegener J, Giaever I (2002) Real-time impedance assay to follow the invasive activities of metastatic cells in culture. Biotechniques 33:842–850
Keese CR, Wegener J, Walker S, Giaever I (2004) Electrical wound-healing assay for cells in vitro. Proc Natl Acad Sci USA 101:1554–1559
Lo CM, Linton M, Keese CR, Giaever I (2001) Correlated motion and oscillation of neighboring cells in vitro. Cell Commun Adhes 8(3):139–145
Reddy L, Wang H, Keese CR, Giaever I, Smith T (1998) Assessment of rapid morphological changes associated with elevated cAMP levels in human orbital fibroblasts. Exp Cell Res 245:360–367
Stolwijk J, Hartmann C, Balani P, Albermann S, Keese CR, Giaever I, Wegener J (2011) Impedance analysis of adherent cells after in situ electroporation: non-invasive monitoring during intracellular manipulations. Biosens Bioelectron 26:4720–4727
Tiruppathi C, Malik A, Del Vecchio PJ, Keese CR, Giaever I (1992) Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc Natl Acad Sci USA 88:7919–7923
Wegener J, Keese CR, Giaever I (2000) Electroporation of adherent cells on a conductive substrate and electrical in situ monitoring of the cell response. Biotechniques 33:348–357
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© 2012 Springer Science+Business Media Dordrecht
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Giaever, I., Keese, C.R. (2012). Electric Cell-Substrate Impedance Sensing Concept to Commercialization. In: Jiang, W. (eds) Electric Cell-Substrate Impedance Sensing and Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4927-6_1
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DOI: https://doi.org/10.1007/978-94-007-4927-6_1
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Online ISBN: 978-94-007-4927-6
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