Chapter

Systems Biology in Cancer Research and Drug Discovery

pp 229-244

Date:

Applications of Network Bioinformatics to Cancer Angiogenesis

  • Corban G. RiveraAffiliated withDepartment of Biomedical Engineering, Johns Hopkins UniversityHigh-Throughput Biology Center, Johns Hopkins School of Medicine, Johns Hopkins University Email author 
  • , Liang-Hui ChuAffiliated withDepartment of Biomedical Engineering, Johns Hopkins University
  • , Joel S. BaderAffiliated withDepartment of Biomedical Engineering, Johns Hopkins UniversityHigh-Throughput Biology Center, Johns Hopkins School of Medicine, Johns Hopkins University
  • , Aleksander S. PopelAffiliated withDepartment of Biomedical Engineering, Johns Hopkins University

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Abstract

Angiogenesis is the formation of new blood vessels from preexisting microvessels. Excessive and insufficient angiogenesis has been associated with many diseases including cancer, age-related macular degeneration, ischemic heart, brain, and skeletal muscle diseases. In this book chapter, we focus on the biological networks associated with angiogenesis in cancer. We review diverse studies on angiogenesis networks, including angiogenic signaling and angiogenic switch networks, global angiogenesis protein-protein interaction networks, crosstalk among angiogenic pathways, and drug networks. This chapter is for readers who are interested in cancer systems biology and bioinformatics, especially in angiogenesis.

Keywords

Network biology Network bioinformatics Bioinformatics Angio-genesis Angiogenesis signaling networks Protein interaction networks