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Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach

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Systems Biology in Cancer Research and Drug Discovery

Abstract

The process of sprouting angiogenesis is extremely complex involving hundreds of proteins that regulate transcription and participate in signaling pathways controlling cellular movement, proliferation and phenotype alteration. Modeling has been attempted to understand all these mechanisms, and hence, in this chapter, we will focus on models that deal individually with each one of these mechanisms relevant to angiogenesis, as well as with platforms that integrate various models into multiscale models of the whole process.

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Abbreviations

ARA:

Aortic ring assay

BrDu:

Bromodeoxyuridine

CAM:

Chick chorioallantoic membrane

DII-4:

Delta like 4 ligand

ECM:

Extracellular matrix

FGF:

Fibroblast growth factors

MMPs:

Matrix metalloproteases

MTT:

(3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide a yellow tetrazole)

NRP1:

Neuropilin coding gene 1

NRP2:

Neuropilin coding gene 2

PGC-1α:

Proliferator-activated-receptor-gamma co-activator

RBP-J:

Recombining binding protein suppressor of hairless

VEGF:

Vascular endothelial growth factor

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Acknowledgements

RDMT and TMRR thank the support by Fundos FEDER through Programa Operacional Factores de Competitividade – COMPETE and by Fundação para a Ciência e Tecnologia, through the project with reference number FCOMP-01-0124-FEDER-015708. RDMT acknowledges the support of Fundação Calouste Gulbenkian and Fundação para a Ciência e Tecnologia through the Estímulo à Investigaçãoand Ciência 2007programs, respectively. This work was supported by a grant from the Instituto de Salud Carlos III/FIS/FEDER (PI10/00883) awarded to JCRM.

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Authors and Affiliations

  1. Visual Neuroscience Lab, Institute for Biomedical Research in Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal

    M. M. Quinas-Guerra

  2. Center of Ophthalmology and Vision Sciences (COCV), Institute for Biomedical Research in Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal

    T. M. Ribeiro-Rodrigues & Rui D. M. Travasso

  3. GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain

    Juan Carlos Rodríguez-Manzaneque

  4. Centro de Física Computacional, Departamento de Física, Universidade de Coimbra, Coimbra, Portugal

    Rui D. M. Travasso

  5. Centro de Física da Matéria Condensada, Universidade de Lisboa, Lisboa, Portugal

    Rui D. M. Travasso

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  1. M. M. Quinas-Guerra
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  2. T. M. Ribeiro-Rodrigues
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  3. Juan Carlos Rodríguez-Manzaneque
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  4. Rui D. M. Travasso
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Correspondence to Rui D. M. Travasso .

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  1. Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA

    Asfar S. Azmi

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Quinas-Guerra, M.M., Ribeiro-Rodrigues, T.M., Rodríguez-Manzaneque, J.C., Travasso, R.D.M. (2012). Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach. In: Azmi, A.S. (eds) Systems Biology in Cancer Research and Drug Discovery. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4819-4_8

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