Skip to main content
SpringerLink
Log in
Book cover

Stem Cells and Cancer Stem Cells, Volume 8 pp 45–54Cite as

The Role of Bone Marrow-Derived Progenitor Cells in Tumor Growth and Angiogenesis

  • Chapter
  • First Online:

  • 1268 Accesses

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 8))

Abstract

As in normal tissues, solid tumors require vascular structures to form conduits for blood, oxygen, and nutrients. Tumors induce sprouting of new blood vessels (angiogenesis) or co-opt preexisting ones. Tumor blood vessels are dysfunctional and characterized by excessive branching and sprouting, leakiness, and inflammation. These abnormalities can contribute to tumor progression. For example, in a process resembling healing wounds, tumor cells and tumor blood vessels secrete factors that mobilize pro-inflammatory, hematopoietic progenitor cells from the bone marrow. These hematopoietic cells are, generally, proangiogenic, and their activity may be partially responsible for the dysfunctional features of tumor blood vessels. Thus, identifying key pathways controlling communication between tumors and bone marrow-derived pro-inflammatory cells will improve our understanding of vascular dysfunction in tumors and contribute to the identification of new therapeutic targets for anti-angiogenesis strategies.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Ahn G-O, Tseng D, Liao C-H, Dorie MJ, Czechowicz A, Brown JM (2010) Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment. Proc Natl Acad Sci USA 107(18):8363–8368

    Article  CAS  PubMed  Google Scholar 

  • Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275(5302):964–967

    Article  CAS  PubMed  Google Scholar 

  • Bailey AS, Willenbring H, Jiang S, Anderson DA, Schroeder DA, Wong MH, Grompe M, Fleming WH (2006) Myeloid lineage progenitors give rise to vascular endothelium. Proc Natl Acad Sci USA 103(35):13156–13161

    Article  CAS  PubMed  Google Scholar 

  • Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D (2000) Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2(10):737–744

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bergfeld SA, Declerck YA (2010) Bone marrow-derived mesenchymal stem cells and the tumor microenvironment. Cancer Metastasis Rev 29(2):249–261

    Article  PubMed  Google Scholar 

  • Biswas SK, Sica A, Lewis CE (2008) Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J Immunol 180(4):2011–2017

    CAS  PubMed  Google Scholar 

  • Coussens LM, Tinkle CL, Hanahan D, Werb Z (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103(3):481–490

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Crisan M, Yap S, Casteilla L, Chen C-W, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng P-N, Traas J, Schugar R, Deasy BM, Badylak S, Buhring H-J, Giacobino J-P, Lazzari L, Huard J, Péault B (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3(3):301–313

    Article  CAS  PubMed  Google Scholar 

  • Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G (2008) HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13(3):206–220

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dudley AC, Udagawa T, Melero-Martin JM, Shih S-C, Curatolo A, Moses MA, Klagsbrun M (2010) Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. Blood 116(17):3367–3371

    Article  CAS  PubMed  Google Scholar 

  • Egeblad M, Nakasone ES, Werb Z (2010) Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 18(6):884–901

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Fantin A, Vieira JM, Gestri G, Denti L, Schwarz Q, Prykhozhij S, Peri F, Wilson SW, Ruhrberg C (2010) Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood 116(5):829–840

    Article  CAS  PubMed  Google Scholar 

  • Folkman J (1972) Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 175(3):409–416

    Article  CAS  PubMed  Google Scholar 

  • Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V (2008) Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 319(5860):195–198

    Article  CAS  PubMed  Google Scholar 

  • Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Jung S, Yung S, Chimenti S, Landsman L, Abramovitch R, Keshet E (2006) VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124(1):175–189

    Article  CAS  PubMed  Google Scholar 

  • Ingram DA, Mead LE, Tanaka H, Meade V, Fenoglio A, Mortell K, Pollok K, Ferkowicz MJ, Gilley D, Yoder MC (2004) Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 104(9):2752–2760

    Article  CAS  PubMed  Google Scholar 

  • Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438(7069):820–827

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449(7162):557–563

    Article  CAS  PubMed  Google Scholar 

  • Kidd S, Spaeth E, Dembinski JL, Dietrich M, Watson K, Klopp A, Battula VL, Weil M, Andreeff M, Marini FC (2009) Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells 27(10):2614–2623

    Article  CAS  PubMed  Google Scholar 

  • Lin Y, Weisdorf DJ, Solovey A, Hebbel RP (2000) Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 105(1):71–77

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Melero-Martin JM, de Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J (2010) Host myeloid cells are necessary for creating bioengineered human vascular networks in vivo. Tissue Eng Part A 16(8):2457–2466

    Article  CAS  PubMed  Google Scholar 

  • Murdoch C, Muthana M, Coffelt SB, Lewis CE (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer 8(8):618–631

    Article  CAS  PubMed  Google Scholar 

  • Nozawa H, Chiu C, Hanahan D (2006) Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci USA 103(33):12493–12498

    Article  CAS  PubMed  Google Scholar 

  • Olive K, Jacobetz M, Davidson C, Gopinathan A, Mcintyre D, Honess D, Madhu B, Goldgraben M, Caldwell M, Allard D (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933):1457

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Peters BA, Diaz LA, Polyak K, Meszler L, Romans K, Guinan EC, Antin JH, Myerson D, Hamilton SR, Vogelstein B, Kinzler KW, Lengauer C (2005) Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 11(3):261–262

    Article  CAS  PubMed  Google Scholar 

  • Purhonen S, Palm J, Rossi D, Kaskenpää N, Rajantie I, Ylä-Herttuala S, Alitalo K, Weissman IL, Salven P (2008) Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci USA 105(18):6620–6625

    Article  CAS  PubMed  Google Scholar 

  • Qian B-Z, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, Kaise EA, Snyder LA, Pollard JW (2011) CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475:222–225

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Quante M, Tu SP, Tomita H, Gonda T, Wang SSW, Takashi S, Baik GH, Shibata W, DiPrete B, Betz KS, Friedman R, Varro A, Tycko B, Wang TC (2011) Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell 19(2):257–272

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Roodhart JML, Daenen LGM, Stigter ECA, Prins H-J, Gerrits J, Houthuijzen JM, Gerritsen MG, Schipper HS, Backer MJG, van Amersfoort M, Vermaat JSP, Moerer P, Ishihara K, Kalkhoven E, Beijnen JH, Derksen PWB, Medema RH, Martens AC, Brenkman AB, Voest EE (2011) Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell 20(3):370–383

    Article  CAS  PubMed  Google Scholar 

  • Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, Hicklin DJ, Chaplin D, Foster FS, Benezra R, Kerbel RS (2006) Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313(5794):1785–1787

    Article  CAS  PubMed  Google Scholar 

  • Shojaei F, Wu X, Malik AK, Zhong C, Baldwin ME, Schanz S, Fuh G, Gerber H-P, Ferrara N (2007) Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol 25(8):911–920

    Article  CAS  PubMed  Google Scholar 

  • Takakura N, Watanabe T, Suenobu S, Yamada Y, Noda T, Ito Y, Satake M, Suda T (2000) A role for hematopoietic stem cells in promoting angiogenesis. Cell 102(2):199–209

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Cao F, De A, Cao Y, Contag C, Gambhir SS, Wu JC, Chen X (2009) Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells 27(7):1548–1558

    Article  CAS  PubMed  Google Scholar 

  • Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, Carbone DP, Matrisian LM, Richmond A, Lin PC, Moses HL (2008) Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13(1):23–35

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Yoder MC, Mead LE, Prater D, Krier TR, Mroueh KN, Li F, Krasich R, Temm CJ, Prchal JT, Ingram DA (2007) Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 109(5):1801–1809

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell and Molecular Physiology, University of North Carolina, 8340 Medical Biomolecular Research Building, Chapel Hill, NC, 27599, USA

    Andrew C. Dudley & Erica W. Cloer

  2. Department of Cardiac Surgery, Harvard Medical School, Boston, MA, 02115, USA

    Juan M. Melero-Martin

Authors
  1. Andrew C. Dudley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Erica W. Cloer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Juan M. Melero-Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrew C. Dudley .

Editor information

Editors and Affiliations

  1. Biology, Kean University, Union, New Jersey, USA

    M.A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Dudley, A.C., Cloer, E.W., Melero-Martin, J.M. (2012). The Role of Bone Marrow-Derived Progenitor Cells in Tumor Growth and Angiogenesis. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 8. Stem Cells and Cancer Stem Cells, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4798-2_5

Download citation

Publish with us

Policies and ethics

Search

Navigation