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Stem Cells and Cancer Stem Cells, Volume 8 pp 123–131Cite as

Regulation of Self-Renewal and Pluripotency of Embryonic Stem Cells: Role of Natriuretic Peptide Receptor A

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 8))

Abstract

Embryonic stem (ES) cells have two defining properties: self-renewal and pluripotency, and these make them a promising source for cell transplantation therapies. Oct4, Nanog, and Sox2 are the main transcription factors in regulating ES cell pluripotency. These key factors have also been identified that form an intrinsic core-regulatory circuit that maintains ES cells in the pluripotent state in vitro. The precise mechanism of how these processes are regulated remains largely unknown. Thus investigation of the molecular and cellular mechanisms of stem cell self-renewal and pluripotency provide the necessary tools to harness the regenerative potential of ES cells for therapeutic purposes. Recently, we have showed that natriuretic peptide receptor A (NPR-A), a specific receptor for atrial and brain natriuretic peptide (ANP and BNP), is expressed in preimplantation embryos and in ES cells, and is functional in ES cells. In this chapter, we will provide an overview on the importance of identifying the expression and function of NPR-A in maintaining ES cell characteristics.

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Author information

Authors and Affiliations

  1. Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

    Essam M. Abdelalim

  2. Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-Cho, Otsu, Shiga, 520-2192, Japan

    Essam M. Abdelalim

  3. Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga, 520-2192, Japan

    Ikuo Tooyama

Authors
  1. Essam M. Abdelalim
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  2. Ikuo Tooyama
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Correspondence to Essam M. Abdelalim .

Editor information

Editors and Affiliations

  1. Biology, Kean University, Union, New Jersey, USA

    M.A. Hayat

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Abdelalim, E.M., Tooyama, I. (2012). Regulation of Self-Renewal and Pluripotency of Embryonic Stem Cells: Role of Natriuretic Peptide Receptor A. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 8. Stem Cells and Cancer Stem Cells, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4798-2_12

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