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Diagnosis and Treatment of Malignant Pleural Effusion

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Malignant Effusions

Abstract

Malignant pleural effusion (MPE) is a common clinical problem in patients with neoplastic disease. The optimal palliative management for patients with symptomatic MPE is not well understood. There is a variety of possible treatments: thoracentesis or repeat thoracentesis; instillation of irritating agents into the pleural cavity by the thoracostomy tube or under thoracoscopic vision; alternatives to the pleurodesis such as chronic indwelling pleural catheter and pleuroperitoneal shunt for those cases with trapped lung. The treatment choice depends on the clinician’s specialty and expertise, the patient’s performance status and the hospitalization status. This chapter presents a comprehensive review of the current methods for diagnosing and managing patients with MPE.

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References

  1. Agarwal R, Agarwal AN, Gupta D (2006) Efficacy and safety of iodopovidone pleurodesis through tube thoracostomy. Respirology 11:105–108

    Article  PubMed  Google Scholar 

  2. American Thoracic Society (2000) Management of malignant pleural effusions. Am J Respir Crit Care Med 162:1987–2001

    Article  Google Scholar 

  3. Antony VB, Loddenkemper R, Astoul P, Boutin C, Goldstraw P, Hott J, Rodriguez-Panadero F, Sahn SA (2001) Management of malignant pleural effusions. Eur Respir J 18:402–419

    Article  PubMed  CAS  Google Scholar 

  4. Antunes G, Neville E (2000) Management of malignant pleural effusions. Thorax 55:981–983

    Article  PubMed  CAS  Google Scholar 

  5. Baly TC, Kisner DL, Sybert A, Macdonald JS, Tsou E, Schein PS (1978) Tetracycline and quinacrine in the control of malignant pleural effusions: a randomized trial. Cancer 41:1188–1192

    Article  Google Scholar 

  6. Barbetakis N, Vassiliadis M, Kaplanis K, Valeri R, Tsilikas C (2004) Mitoxantrone pleurodesis to palliate malignant pleural effusion secondary to ovarian cancer. BMC Palliat Care 3:4

    Article  PubMed  CAS  Google Scholar 

  7. Baumann MH (1998) Closed needle biopsy of the pleura is a valuable diagnostic procedure. Proclosed needle biopsy. J Bronchol 5:327–331

    Article  Google Scholar 

  8. Baumann MH (2006) Closed pleural biopsy: not dead yet! Chest 129:1398–1400

    Article  PubMed  Google Scholar 

  9. Benamore RE, Scott K, Richards CJ, Entwisle JJ (2006) Image-guided pleural biopsy: diagnostic yield and complications. Clin Radiol 61:700–705

    Article  PubMed  CAS  Google Scholar 

  10. Bethune N (1935) Pleural poudrage: a new technique for deliberate production of pleural adhesions as a preliminary to lobectomy. J Thorac Surg 4:251–261

    Google Scholar 

  11. Bielsa S, Hernández P, Rodriguez-Panadero F et al (2011) Tumor type influences the effectiveness of pleurodesis in malignant effusions. Lung 189:151–155

    Article  PubMed  Google Scholar 

  12. Blackmore CC, Black WC, Dallas RC, Crow HC (1996) Pleural fluid volume estimation: a chest radiograph prediction rule. Acad Radiol 3:103–109

    Article  PubMed  CAS  Google Scholar 

  13. British Thoracic Society Standards of Care Committee (2007) BTS statement on malignant mesothelioma in the UK, 2007. Thorax 62:ii1–ii19

    Article  Google Scholar 

  14. Canto A, Rivas J, Saumench J, Morera R, Moya J (1983) Points to consider when choosing a biopsy method in cases of pleurisy of unknown origin. Chest 84:176–179

    Article  PubMed  CAS  Google Scholar 

  15. Chakrabarti B, Ryland I, Sheard J, Warburton CJ, Earis JE (2006) The role of Abrams percutaneous pleural biopsy in the investigation of exudative pleural effusions. Chest 129:1549–1555

    Article  PubMed  Google Scholar 

  16. Chernow B, Sahn SA (1977) Carcinomatous involvement of the pleura: an analysis of 96 patients. Am J Med 63:695–702

    Article  PubMed  CAS  Google Scholar 

  17. Chrysanthidis MG, Janssen JP (2005) Autofluorescence videothoracoscopy in exudative pleural effusions: preliminary results. Eur Respir J 26:989–992

    Article  PubMed  CAS  Google Scholar 

  18. Colt HG, Davoudi M (2008) The ideal pleurodesis agent: still searching after all these years. Lancet 9:912–913

    Article  Google Scholar 

  19. Creaney J, Yeoman D, Naumoff LK, Hof M et al (2007) Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma. Thorax 62:569–576

    Article  PubMed  Google Scholar 

  20. Demmy TL, Gu L, Burkhalter JE, Toloza EM, D’Amico TA, Sutherland S, Wang XF, Archer L, Veit LJ, Kohman L (2010) Comparison of indwelling catheters and talc pleurodesis in the management of malignant pleural effusions. J Clin Oncol 28:15s (suppl; abstr 9031)

    Google Scholar 

  21. Diacon AH, Brutsche MH, Soler M (2003) Accuracy of pleural puncture sites: a prospective comparison of clinical examination with ultrasound. Chest 123:436–441

    Article  PubMed  Google Scholar 

  22. Dickgreber NJ, Sorensen JB, Paz-Ares LG et al (2010) Pemetrexed safety and pharmacokinetics in patients with third-space fluid. Clin Cancer Res 16:2872–2880

    Article  PubMed  CAS  Google Scholar 

  23. Dikensoy O, Light RW (2005) Alternative widely available, inexpensive agents for pleurodesis. Curr Opin Pulm Med 11:340–344

    Article  PubMed  Google Scholar 

  24. Duysinx B, Nguyen D, Louis R et al (2004) Evaluation of pleural disease with 18-fluorodeoxyglucose positron emission tomography imaging. Chest 125:489–493

    Article  PubMed  Google Scholar 

  25. Duysinx BC, Corhay JL, Hubin L et al (2008) Diagnostic value of interleukine-6, transforming growth factor-beta 1 and vascular endothelial growth factor in malignant pleural effusions. Respir Med 102:1708–1714

    Article  PubMed  Google Scholar 

  26. Erasmus JJ, McAdams HP, Rossi SE, Goodman PC, Coleman RE, Patz EF (2000) FDG PET of pleural effusions in patients with non-small cell lung cancer. AJR Am J Roentgenol 175:245–249

    Article  PubMed  CAS  Google Scholar 

  27. Ferrer J, Villarino MA, Encabo G, Felip E, Bermejo B, Vila S, Orriols R (1999) Diagnostic utility of CYFRA 21–1, carcinoembryonic antigen, CA 125, neuron specific enolase, and squamous cell antigen level determinations in the serum and pleural fluid of patients with pleural effusions. Cancer 86:1488–1495

    Article  PubMed  CAS  Google Scholar 

  28. Foresti V (1995) Intrapleural Corynebacterium parvum for recurrent malignant pleural effusions. Respiration 62:21–26

    Article  PubMed  CAS  Google Scholar 

  29. Francis RJ, Byrne MJ, van der Schaaf AA, Boucek JA, Nowak AK, Phillips M, Price R, Patrikeos AP, Musk AW, Millward MJ (2007) Early prediction of response to chemotherapy and survival in malignant pleural mesothelioma using a novel semiautomated 3-dimensional volume-based analysis of serial 18F-FDG PET scans. J Nucl Med 48:1449–1458

    Article  PubMed  Google Scholar 

  30. Fry WA, Khandekar JD (1995) Parietal pleurectomy for malignant pleural effusion. Ann Surg Oncol 2:160–164

    Article  PubMed  CAS  Google Scholar 

  31. Gaspar MJ, De Miguel J, Garcia Diaz JD, Diez M (2008) Clinical utility of a combination of tumour markers in the diagnosis of malignant pleural effusions. Anticancer Res 28:2947–2952

    PubMed  CAS  Google Scholar 

  32. Groth G, Gatzemeier U, Haussingen K, Heckmayr M, Magnussen H, Neuhauss R, Pavel JV (1991) Intrapleural palliative treatment of malignant pleural effusions with mitoxantrone versus placebo (pleural tube alone). Ann Oncol 2:213–215

    Article  PubMed  CAS  Google Scholar 

  33. Gupta NC, Rogers JS, Graeber GM et al (2002) Clinical role of F-18 fluorodeoxyglucose positron emission tomography imaging in patients with lung cancer and suspected malignant pleural effusion. Chest 122:1918–1924

    Article  PubMed  CAS  Google Scholar 

  34. Heffner JE, Klein JS (2008) Recent advances in the diagnosis and management of malignant pleural effusions. Mayo Clin Proc 83:235–250

    PubMed  Google Scholar 

  35. Heffner JE, Standerfer RJ, Torstveit J, Unruh L (1994) Clinical efficacy of doxycycline for pleurodesis. Chest 105:1743–1747

    Article  PubMed  CAS  Google Scholar 

  36. Hillerdal G, Kiviloog J, Nou E, Steinholtz L (1986) Corynebacterium parvum in malignant pleural effusion: a randomized prospective study. Eur J Respir Dis 69:204–206

    PubMed  CAS  Google Scholar 

  37. Hooper C, Lee YC, Maskell N, B.T.S.P.G. Group, Investigation of a unilateral pleural effusion in adults (2010) British Thoracic Society Pleural Disease Guideline. Thorax 65:ii4–ii17

    Article  PubMed  Google Scholar 

  38. Ishida A, Miyazawa T, Miyazu Y et al (2006) Intrapleural cisplatin and OK432 therapy for malignant pleural effusion caused by non-small cell lung cancer. Respirology 11:90–97

    Article  PubMed  Google Scholar 

  39. Ishida A, Ishikawa F, Nakamura M et al (2009) Narrow band imaging applied to pleuroscopy for the assessment of vascular patterns of the pleura. Respiration 78:432–439

    Article  PubMed  Google Scholar 

  40. Jacobaeus HC (1910) Über die Möglichkeit, die Zystoskopie bei Untersuchungen seröser Höhlungen anzuwenden. Münch Med Wschr 40:2090–2092

    Google Scholar 

  41. Johnston WW (1985) The malignant pleural effusion: a review of cytopathological diagnoses of 584 specimens from 472 consecutive patients. Cancer 56:905–909

    Article  PubMed  CAS  Google Scholar 

  42. Jones DR, Taylor MD, Petroni GR et al (2010) Phase I trial of intrapleural docetaxel administered through an implantable catheter in subjects with a malignant pleural effusion. J Thorac Oncol 5:75–81

    Article  PubMed  Google Scholar 

  43. Joseph J, Viney S, Beck P et al (1992) A prospective study of amylase-rich pleural effusions with special reference to amylase isoenzyme analysis. Chest 102:1455–1459

    Article  PubMed  CAS  Google Scholar 

  44. Kasahara K, Shibata K, Shintani H et al (2006) Randomized phase II trial of OK-432 in patients with malignant pleural effusion due to non-small cell lung cancer. Anticancer Res 26:1495–1499

    PubMed  CAS  Google Scholar 

  45. Kelly-Garcia J, Roman-Berumen JF, Ibarra-Perez C (1997) Iodopovidone and bleomycin pleurodesis for effusions due to malignant epithelial neoplasms. Arch Med Res 28:583–585

    PubMed  CAS  Google Scholar 

  46. Kennedy L, Harley RA, Sahn SA, Strange C (1995) Talc slurry pleurodesis: pleural fluid and histologic analysis. Chest 107:1707–1712

    Article  PubMed  CAS  Google Scholar 

  47. Khaleeq G, Musani AI (2008) Emerging paradigms in the management of malignant pleural effusions. Respir Med 102:939–948

    Article  PubMed  Google Scholar 

  48. Kishi K, Homma S, Sakamoto S et al (2004) Efficacious pleurodesis with OK-432 and doxorubicin against malignant pleural effusions. Eur Respir J 24:263–266

    Article  PubMed  CAS  Google Scholar 

  49. Koldsland S, Svennevig JL, Lehne G, Johnson E (1993) Chemical pleurodesis in malignant pleural effusions: a randomized prospective study of mepacrine versus bleomycin. Thorax 48:790–793

    Article  PubMed  CAS  Google Scholar 

  50. Kolschmann S, Ballin A, Gillissen A (2005) Clinical efficacy and safety of thoracoscopic talc pleurodesis in malignant pleural effusions. Chest 128:1431–1435

    Article  PubMed  Google Scholar 

  51. Kraft A, Weindel K, Ochs A et al (1999) Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease. Cancer 85:178–187

    Article  PubMed  CAS  Google Scholar 

  52. Kramer H, Pieterman RM, Slebos DJ et al (2004) PET for the evaluation of pleural thickening observed on CT. J Nucl Med 45:995–998

    PubMed  Google Scholar 

  53. Kuzdzal J, Sladek K, Wasowski D et al (2003) Talc powder vs doxycycline in the control of malignant pleural effusion: a prospective, randomized trial. Med Sci Monit 9:154–159

    Google Scholar 

  54. Kuzniar TJ, Blum MG, Kasibowska-Kuzniar K, Mutlu GM (2006) Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis. Ann Thorac Surg 82:1976–1981

    Article  PubMed  Google Scholar 

  55. Lee P, Colt HG (2007) State of the art: pleuroscopy. J Thorac Oncol 2:663–670

    Article  PubMed  Google Scholar 

  56. Lee P, Hsu A, Lo C, Colt HG (2007) Prospective evaluation of flex-rigid pleuroscopy for indeterminate pleural effusion: accuracy, safety and outcome. Respirology 12:881–886

    Article  PubMed  Google Scholar 

  57. Lee ST, Ghanem RA, Herbertson SU et al (2009) Prognostic value of 18F-FDG PET/CT in patients with malignant pleural mesothelioma. Mol Imaging Biol 11:473–479

    Article  PubMed  CAS  Google Scholar 

  58. Leuallen EC, Carr DT (1955) Pleural effusion; a statistical study of 436 patients. N Engl J Med 252:79–83

    Article  PubMed  CAS  Google Scholar 

  59. Leung AN, Muller NL, Miller RR (1990) CT in differential diagnosis of diffuse pleural disease. Am J Roentgenol 154:487–492

    Article  CAS  Google Scholar 

  60. Light RW (2001) Pleural diseases. Lippincott/Williams & Wilkins, Baltimore

    Google Scholar 

  61. Lipscomb DJ, Flower CD, Hadfield JW (1981) Ultrasound of the pleura: an assessment of its clinical value. Clin Radiol 32:289–290

    Article  PubMed  CAS  Google Scholar 

  62. Lombardi G, Zustovich F, Nicoletto MO et al (2010) Diagnosis and treatment of malignant pleural effusion: a systematic literature review and new approaches. Am J Clin Oncol 33:420–423

    Article  PubMed  Google Scholar 

  63. Maher GG, Berger HW (1972) Massive pleural effusion: malignant and non-malignant causes in 46 patients. Am Rev Respir Dis 105:458–460

    PubMed  CAS  Google Scholar 

  64. Martini N, Bains MS, Beattie EJ Jr (1975) Indications for pleurectomy in malignant pleural effusion. Cancer 35:734–738

    Article  PubMed  CAS  Google Scholar 

  65. Maruhashi A, Ono K (2008) A novel concept of treatment of diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT). Radiother Oncol 88:192–195

    Article  PubMed  Google Scholar 

  66. Maskell NA, Gleeson FV, Davies RJ (2003) Standard pleural biopsy versus CT-guided cutting-needle biopsy for diagnosis of malignant disease in pleural effusions: a randomised controlled trial. Lancet 361:1326–1330

    Article  PubMed  CAS  Google Scholar 

  67. Matthai SM, Kini U (2003) Diagnostic value of eosinophils in pleural effusion: a prospective study of 26 cases. Diagn Cytopathol 28:96–99

    Article  PubMed  Google Scholar 

  68. Medford AR, Agrawal S, Bennett JA, Free CM, Entwisle JJ (2010) Thoracic ultrasound prior to medical thoracoscopy improves pleural access and predicts fibrous septation. Respirology 15:804–808

    Article  PubMed  Google Scholar 

  69. Metintas M, Ak G, Dundar E et al (2010) Medical thoracoscopy vs CT scan-guided Abrams pleural needle biopsy for diagnosis of patients with pleural effusions: a randomized, controlled trial. Chest 137:1362–1368

    Article  PubMed  Google Scholar 

  70. Michaud G, Berkowitz DM, Ernst A (2010) Pleuroscopy for diagnosis and therapy for pleural effusions. Chest 138:1242–1246

    Article  PubMed  Google Scholar 

  71. Miller E, Lerman H, Gutman M, Figer A, Livshitz G, Even-Sapir E (2004) The clinical impact of camera-based positron emission tomography imaging in patients with recurrent colorectal cancer. Invest Radiol 39:8–12

    Article  PubMed  Google Scholar 

  72. Moffett MJ, Ruckdeschel JC (1992) Bleomycin and tetracycline in malignant pleural effusions: a review. Semin Oncol 19:59–62

    PubMed  CAS  Google Scholar 

  73. Mohsen TA, Zeid AA, Meshref M et al (2011) Local iodine pleurodesis versus thoracoscopic talc insufflation in recurrent malignant pleural effusion: a prospective randomized control trial. Eur J Cardiothorac Surg 40:282–286

    PubMed  Google Scholar 

  74. Montes-Worboys A, Rodriguez-Portal JA, Arellano-Orden E, Digón-Pereiras J, Rodriguez-Panadero F (2010) Interleukin-8 activates coagulation and correlates with survival after talc pleurodesis. Eur Respir J 35:160–166

    Article  PubMed  CAS  Google Scholar 

  75. Neragi-Miandoab S (2006) Malignant pleural effusion, current and evolving approaches for its diagnosis and management. Lung Cancer 54:1–9

    Article  PubMed  Google Scholar 

  76. Neto JD, de Oliveira SF, Vianna SP, Terra RM (2010) Efficacy and safety of iodopovidone pleurodesis in malignant pleural effusions. Respirology 15:115–118

    Article  PubMed  Google Scholar 

  77. O’Donovan PB, Eng P (1994) Pleural changes in malignant pleural effusions: appearance on computed tomography. Cleve Clin J Med 61:127–131

    Article  PubMed  Google Scholar 

  78. Ohm C, Park D, Vogen M et al (2003) Use of indwelling pleural catheter compared with thoracoscopic talc pleurodesis in the management of malignant pleural effusions. Am Surg 69:198–202

    PubMed  Google Scholar 

  79. Olivares-Torres CA, Laniado-Laborin R, Chavez-Garcia C et al (2002) Iodopovidone pleurodesis for recurrent pleural effusions. Chest 122:581–583

    Article  PubMed  CAS  Google Scholar 

  80. Orki A, Akin O, Tasci AE, Ciftci H, Urek S, Falay O, Kutlu KA (2009) The role of positron emission tomography/computed tomography in the diagnosis of pleural diseases. Thorac Cardiovasc Surg 57:217–221

    Article  PubMed  CAS  Google Scholar 

  81. Paschoalini Mda S, Vargas FS, Marchi E, Pereira JR, Jatene FB, Antonangelo L, Light RW (2005) Prospective randomized trial of silver nitrate vs talc slurry in pleurodesis for symptomatic malignant pleural effusions. Chest 128:684–689

    Article  PubMed  Google Scholar 

  82. Pollak JS, Burdge CM, Rosenblatt M et al (2001) Treatment of malignant pleural effusions with tunnelled long-term drainage catheters. J Vasc Intervent Radiol 12:201–208

    Article  CAS  Google Scholar 

  83. Porcel JM, Vives M, Esquerda A et al (2004) Use of a panel of tumor markers (carcinoembryonic antigen, cancer antigen 125, carbohydrate antigen 15–3, and cytokeratin 19 fragments) in pleural fluid for the differential diagnosis of benign and malignant effusions. Chest 126:1757–1763

    Article  PubMed  Google Scholar 

  84. Porcel JM, Salud A, Nabal M et al (2006) Rapid pleurodesis with doxycycline through a small-bore catheter for the treatment of metastatic malignant effusions. Support Care Cancer 14:475–478

    Article  PubMed  Google Scholar 

  85. Prakash UB, Reiman HM (1985) Comparison of needle biopsy with cytologic analysis for the evaluation of pleural effusion: analysis of 414 cases. Mayo Clin Proc 60:158–164

    Article  PubMed  CAS  Google Scholar 

  86. Psathakis K, Calderón-Osuna E, Romero-Romero B et al (2006) The neutrophilic and fibrinolytic response to talc can predict the outcome of pleurodesis. Eur Respir J 27:817–821

    Article  PubMed  CAS  Google Scholar 

  87. Putnam JB Jr, Light RW, Rodriguez RM et al (1999) A randomized comparison of indwelling pleural catheter and doxycycline pleurodesis in the management of malignant pleural effusions. Cancer 86:1992–1999

    Article  PubMed  Google Scholar 

  88. Putnam JB, Walsh GL, Swisher SG et al (2000) Outpatient management of malignant pleural effusion by a chronic indwelling pleural catheter. Ann Thorac Surg 69:369–375

    Article  PubMed  Google Scholar 

  89. Qureshi NR, Rahman NM, Gleeson FV (2009) Thoracic ultrasound in the diagnosis of malignant pleural effusion. Thorax 64:139–143

    Article  PubMed  CAS  Google Scholar 

  90. Rice D, Rusch V, Pass H, International Association for the Study of Lung Cancer International Staging Committee and the International Mesothelioma Interest Group et al (2011) Recommendations for uniform definitions of surgical techniques for malignant pleural mesothelioma: a consensus report of the International Association for the Study of Lung Cancer International Staging Committee and the International Mesothelioma Interest Group. J Thorac Oncol 6:1304–1312

    Article  PubMed  Google Scholar 

  91. Roberts ME, Neville E, Berrisford RG, BTS Pleural Disease Guideline Group et al (2010) Management of a malignant pleural effusion: British Thoracic Society Pleural Disease Guideline. Thorax 65:ii32–ii40

    Article  PubMed  Google Scholar 

  92. Robinson WD, Like R (2005) Advances in malignant mesothelioma. N Engl J Med 353:1591–1603

    Article  PubMed  CAS  Google Scholar 

  93. Rodriguez-Panadero F (2008) Medical thoracoscopy. Respiration 76:363–372

    Article  PubMed  Google Scholar 

  94. Rodriguez-Panadero F, Antony VB (1997) Pleurodesis: state of the art. Eur Respir J 10:1648–1654

    Article  PubMed  CAS  Google Scholar 

  95. Rodriguez-Panadero F, Lopez J (1989) Low glucose and pH levels in malignant pleural effusions. Diagnostic significance and prognostic value in respect to pleurodesis. Am Rev Respir Dis 139:663–667

    Article  PubMed  CAS  Google Scholar 

  96. Rodriguez-Panadero F, Romero-Romero B (2011) Management of malignant pleural effusions. Curr Opin Pulm Med 17(4):269–273

    Article  PubMed  Google Scholar 

  97. Rohren EM, Turkington TG, Coleman RE (2004) Clinical applications of PET in oncology. Radiology 231:305–332

    Article  PubMed  Google Scholar 

  98. Ruskin JA, Gurney JW, Thorsen MK, Goodman LR (1987) Detection of pleural effusions on supine chest radiographs. AJR Am J Roentgenol 148:681–683

    Article  PubMed  CAS  Google Scholar 

  99. Sahn SA (1997) Pleural diseases related to metastatic malignancies. Eur Respir J 10:1907–1913

    Article  PubMed  CAS  Google Scholar 

  100. Sahn SA (1998) Malignancy metastatic to the pleura. Clin Chest Med 19:351–361

    Article  PubMed  CAS  Google Scholar 

  101. Sahn SA, Good JT Jr (1988) Pleural fluid pH in malignant effusions. Diagnostic, prognostic, and therapeutic implications. Ann Intern Med 108:345–349

    Article  PubMed  CAS  Google Scholar 

  102. Sartori S, Tassinari D, Ceccotti P et al (2004) Prospective randomized trial of intrapleural bleomycin versus interferon alfa-2b via ultrasound-guided small-bore chest tube in the palliative treatment of malignant pleural effusions. J Clin Oncol 22:1228–1233

    Article  PubMed  CAS  Google Scholar 

  103. Schaffler GJ, Wolf G, Schoellnast H et al (2004) Non-small cell lung cancer: evaluation of pleural abnormalities on CT scans with 18F FDG PET. Radiology 231:858–865

    Article  PubMed  Google Scholar 

  104. Scherpereel A, Astoul P, Baas P, European Respiratory Society, European Society of Thoracic Surgeons et al (2010) Guidelines of the ERS/ ESTS for management of malignant pleural mesothelioma. Eur Respir J 35:479–495

    Article  PubMed  CAS  Google Scholar 

  105. Shaw P, Agarwal R (2004) Pleurodesis dor malignant pleural effusions. Cochrane database Syst Rev, (1):CD002916

    Google Scholar 

  106. Sorensen JB, Ravn J, Loft A et al (2008) Mesothelioma, preoperative staging of mesothelioma by 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography fused imaging and mediastinoscopy compared to pathological findings after extrapleural pneumonectomy. Eur J Cardiothorac Surg 34:1090–1096

    Article  PubMed  Google Scholar 

  107. Soysal O, Karaoglanoglu N, Demiracan S et al (1997) Pleurectomy/decortication for palliation in malignant pleural mesothelioma: results of surgery. Eur J Cardiothorac Surg 11:210–213

    Article  PubMed  CAS  Google Scholar 

  108. Stathopoulos GT (2010) Translational advances in pleural malignancies. Respirology 16:53–63

    Article  Google Scholar 

  109. Staub NC, Wiener-Kronish JP, Albertine KH (1985) Transport through the pleura: physiology of normal liquid and solute exchange in the pleural space. In: Chretien J, Bignon J, Hirsch A (eds) The pleura in health and disease. Marcel Dekker, New York, pp 169–193

    Google Scholar 

  110. Storey DD, Dines DE, Coles DT (1976) Pleural effusion. A diagnostic dilemma. JAMA 236:2183–2186

    Article  PubMed  CAS  Google Scholar 

  111. Suzuki M, Endo K, Satoh H et al (2006) The evidence on the effectiveness of management for malignant pleural effusion: a systematic review. Eur J Cardiothorac Surg 29:829–838

    Article  Google Scholar 

  112. Tan C, Sedrakyan A, Browne J et al (2006) The evidence on the effectiveness of management for malignant pleural effusion: a systematic review. Eur J Cardiothorac Surg 29:829–838

    Article  PubMed  Google Scholar 

  113. Tan C, Barrington S, Rankin S et al (2010) Role of integrated 18-fluorodeoxyglucose position emission tomography-computed tomography in patients surveillance after multimodality therapy of malignant pleural mesothelioma. J Thorac Oncol 5:385–388

    Article  PubMed  Google Scholar 

  114. Terra RM, Kim SY, Pego-Fernandes PM et al (2010) Is silver nitrate pleurodesis for patients with malignant pleural effusion feasible and safe when performed in an outpatient setting? Ann Surg Oncol 18:1145–1150

    Article  PubMed  Google Scholar 

  115. Tomita M, Shimizu T, Matsuzaki Y et al (2005) Prognostic significance of carcinoembryonic antigen level in pleural lavage fluid for patients with lung adenocarcinoma. Ann Thorac Surg 80:276–281

    Article  PubMed  Google Scholar 

  116. Traill ZC, Davies RJ, Gleeson FV (2001) Thoracic computed tomography in patients with suspected malignant pleural effusions. Clin Radiol 56:193–196

    Article  PubMed  CAS  Google Scholar 

  117. Treasure T, Lang-Lazdunski L, Waller D, MARS trialists et al (2011) Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study. Lancet Oncol 12:763–772

    Article  PubMed  Google Scholar 

  118. Van de Molengraft FJ, Vooijs GP (1989) Survival of patients with malignancy-associated effusions. Acta Cytol 33:911–916

    PubMed  Google Scholar 

  119. Van Meerbeeck JP, Gaafar R, Manegold C, European Organisation for Research and Treatment of Cancer Lung Cancer Group et al (2005) Randomized phase III study of cisplatin with or without raltitrexed inpatients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. J Clin Oncol 23:6881–6889

    Article  PubMed  CAS  Google Scholar 

  120. Viallat JR, Rey F, Astoul P, Boutin C (1996) Thoracoscopic talc poudrage pleurodesis for malignant effusions. A review of 360 cases. Chest 110:1387–1393

    Article  PubMed  CAS  Google Scholar 

  121. Villena V, López-Encuentra A, Echave-Sustaeta J et al (1996) Diagnostic value of CA 72–4, carcinoembryonic antigen, CA 15–3, and CA 19–9 assay in pleural fluid: a study of 207 patients. Cancer 78:736–740

    Article  PubMed  CAS  Google Scholar 

  122. Vogelzang NJ, Rusthoven JJ, Symanowski J et al (2003) Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 21:2636–2644

    Article  PubMed  CAS  Google Scholar 

  123. Walker-Renard PB, Vaughan LM, Sahn SA (1994) Chemical pleurodesis for malignant pleural effusions. Ann Intern Med 120:56–64

    Article  PubMed  CAS  Google Scholar 

  124. Waller DA, Morritt GN, Forty J (1995) Video-assisted thoracoscopic pleurectomy in the management of malignant pleural effusion. Chest 107:1454–1456

    Article  PubMed  CAS  Google Scholar 

  125. Wang X, Zhou J, Wang Y et al (2010) A phase I clinical and pharmaco-kinetic study of paclitaxel liposome infused in non-small cell lung cancer patients with malignant pleural effusions. Eur J Cancer 46:1474–1480

    Article  PubMed  CAS  Google Scholar 

  126. Weissberg D, Ben-Zeev I (1993) Talc pleurodesis. Experience with 360 patients. J Thorac Cardiovasc Surg 106:689–695

    PubMed  CAS  Google Scholar 

  127. Wilkins HE III, Connolly MM, Grays P et al (1997) Recombinant interferon alpha-2b in the management of malignant pleural effusions. Chest 111:1597–1599

    Article  PubMed  Google Scholar 

  128. Yildirim H, Metintas M, Güntülü AK et al (2008) Predictors of talc pleurodesis outcome in patients with malignant pleural effusions. Lung Cancer 62:139–144

    Article  PubMed  Google Scholar 

  129. Zaric B, Kuruc V, Milovancev A et al (2008) Differential diagnosis of tuberculous and malignant pleural effusions: what is the role of adenosine deaminase? Lung 186:233–240

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Sergi Call .

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Call, S., Sánchez, D., Rami-Porta, R. (2012). Diagnosis and Treatment of Malignant Pleural Effusion. In: Kiselevsky, M. (eds) Malignant Effusions. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4783-8_3

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