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Tumor Ablation pp 61–75Cite as

High Intensity Focused Ultrasound (HIFU) Ablation

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Part of the book series: The Tumor Microenvironment ((TTME,volume 5))

Abstract

The ideal cancer therapy not only induces the death of all localized tumor cells without damage to surrounding normal tissue, but also activates a systemic antitumor immunity. High intensity focused ultrasound (HIFU) has the potential to be such a treatment, as it can non-invasively ablate a targeted tumor below the skin surface, and may subsequently augment host antitumor immunity. This chapter is to introduce the history and principles of HIFU tumor ablation, and its biological effects on the tumor microenvironment. It will review increasing pre-clinical and clinical evidence suggesting that HIFU ablation may enhance host antitumor immunity, and discuss its potential mechanisms and roles in terms of local recurrence and metastasis control after HIFU treatment.

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Authors and Affiliations

  1. Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University, 1 Medical College Road, 400016, Chongqing, P.R. China

    Feng Wu MD Ph.D.

  2. Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, Oxford, UK

    Feng Wu MD Ph.D.

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  1. Feng Wu MD Ph.D.
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Correspondence to Feng Wu MD Ph.D. .

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Editors and Affiliations

  1. and Immunology, Tel Aviv University, Department of Clinical Microbiology, Tel Aviv, 69978, Israel

    Yona Keisari

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Wu, F. (2013). High Intensity Focused Ultrasound (HIFU) Ablation. In: Keisari, Y. (eds) Tumor Ablation. The Tumor Microenvironment, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4694-7_4

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