Abstract
The cerebellum is involved in the coordination of voluntary motor movement, balance and equilibrium and muscle tone. To date, there is no treatment that can cure or substantially prolong the life span of individuals affected by cerebellar disorders, such as hereditary ataxias, that include the autosomal dominant spinocerebellar ataxias (SCAs), autosomal recessive or X-linked form of disease. Compared with other stem cell types, hESC and human induced pluripotency stem (hiPS) cells currently show the greatest potential for differentiation and cell replacement therapies. Here we evaluate the protocol for differentiation of human embryonic stem cells toward specific cerebellar progenitors and possible therapeutic effects in the treatment of cerebellar ataxias.
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Erceg, S., Stojkovic, M. (2012). Treatment of Cerebellar Ataxias: Transplantation of Human Embryonic Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 7. Stem Cells and Cancer Stem Cells, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4285-7_19
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DOI: https://doi.org/10.1007/978-94-007-4285-7_19
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