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Midkine: From Embryogenesis to Pathogenesis and Therapy pp 15–28Cite as

The Role of Midkine in Neural Development and Patterning

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Abstract

Since its discovery almost 25 years ago, numerous functions have been reported for the growth factor midkine in different cellular contexts. In this chapter, we will discuss approaches to understand the function of midkine in the developing nervous system of vertebrates. Functional studies in several animal models have revealed midkine’s role in important cell fate decisions during embryonic neurogenesis. Among these models, zebrafish has been particularly useful for the analysis of midkine, as a genome duplication during teleost evolution resulted in two midkine genes with non-overlapping expression and activities, allowing a detailed dissection of functional aspects during neurogenesis. In zebrafish, the knock-down of midkine results in the absence of distinct cell types in the developing spinal cord, highlighting its importance in cell fate specification during neural patterning. In humans, midkine and its putative receptor Anaplastic Lymphoma Kinase (ALK) are implicated in a variety of neurological disorders including cancers of neural origin. Therefore, studies that aim at understanding midkines’ function and activity in the developing nervous system could become extremely helpful for understanding the molecular mechanisms underlying these diseases. This in turn could lead to the development of novel strategies that use midkine and its associated factors as promising therapeutic targets.

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Authors and Affiliations

  1. Department of Biological Sciences, NUS Centre for Bioimaging Sciences (CBIS), National University of Singapore, 14 Science Drive 4, S1A-06-07, Singapore, 117543, Singapore

    Sheng Yao & Christoph Winkler

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  1. Sheng Yao
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  2. Christoph Winkler
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Correspondence to Christoph Winkler .

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Editors and Affiliations

  1. Faculty of Medicine, Faculty of Biochemistry, Yeni Yüzyıl University, Yilanli Ayazma 26, Istanbul, 34000, Istanbul, Turkey

    Mine Ergüven

  2. , Department of Health Science, Aichi Gakuin University, 12 Araike, Iwasakicho, Nisshin, Aichi, Japan

    Takashi Muramatsu

  3. , Department of Histology and Embryology, Istanbul University Faculty of Medicine, Millet, Istanbul, Turkey

    Ayhan Bilir

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Funding:  This work is supported by an AcRF Tier 1 grant from NUS (R-154-000-478-112).

Conflict of interest: The authors state that they have no conflict of interest.

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Yao, S., Winkler, C. (2012). The Role of Midkine in Neural Development and Patterning. In: Ergüven, M., Muramatsu, T., Bilir, A. (eds) Midkine: From Embryogenesis to Pathogenesis and Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4234-5_2

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