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Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease pp 9–35Cite as

Evolution of the Cadherin–Catenin Complex

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 60))

Abstract

Adherens junctions are the most common junction type found in animal epithelia. Their core components are classical cadherins and catenins, which form membrane-spanning complexes that mediate intercellular binding on the extracellular side and associate with the actin cytoskeleton on the intracellular side. Junctional cadherin–catenin complexes are key elements involved in driving animal morphogenesis. Despite their ubiquity and importance, comparative studies of classical cadherins, catenins and their related molecules suggest that the cadherin/catenin-based adherens junctions have undergone structural and compositional transitions during the diversification of animal lineages. This chapter describes the molecular diversities related to the cadherin–catenin complex, based on accumulated molecular and genomic information. Understanding when and how the junctional cadherin–catenin complex originated, and its subsequent diversification in animals, promotes a comprehensive understanding of the mechanisms of animal morphological diversification.

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Acknowledgments

I would like to thank Shicui Zhang for having supported my access to amphioxus embryos; Tomohiro Haruta for his permission to use unpublished electron micrographs; and Yasuko Akiyama-Oda for her comments on the manuscript.

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  1. JT Biohistory Research Hall, 1–1 Murasaki-cho, 569–1125, Takatsuki, Osaka, Japan

    Oda Hiroki

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  1. , Cell and Systems Biology, University of Toronto, Harbord Street 25, Toronto, M5S 3G5, Ontario, Canada

    Tony Harris

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Hiroki, O. (2012). Evolution of the Cadherin–Catenin Complex. In: Harris, T. (eds) Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease. Subcellular Biochemistry, vol 60. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4186-7_2

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