Abstract
This chapter outlines the basic features and applications of Magnetic Source Imaging (MSI) as a tool for studying the functional organization of the brain circuits that support phonological decoding and word recognition. MSI provides temporal resolution in the order of milliseconds and adequate spatial resolution in order to (a) determine if the degree, peak latency, and temporal progression of regional activity vary systematically with individual differences in reading ability, and (b) identify cortical regions where activity predicts reading achievement scores. A series of small and larger-scale studies are described utilizing clinically validated source-parameter estimation techniques as well as minimum norm estimation procedures which permit modeling of distributed cortical magnetic sources. Results demonstrate that reading-impaired children show reduced activation of posterior temporal and inferior parietal regions during late stages of stimulus processing, mainly in the left hemisphere. Specific task demands, i.e. lexical characteristics and memory involvement may determine additional features of brain activation profiles, including hemispheric distribution of group effects, and the degree of prefrontal involvement in the reading process. These effects are present regardless of comorbidity with attention deficit hyperactivity disorder (ADHD), and also highlight the importance of early activity in the left fusiform gyrus for both word and pseudoword reading ability. The key role of these regions into the developing brain mechanism for reading receives further support from intervention studies, demonstrating “normalizing” changes in the degree and latency of regional activation.
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References
Bonafina, M. A., Newcorn, J. H., McKay, K. E., Koda, V. H., & Halperin, J. M. (2000). ADHD and reading disabilities: A cluster analytic approach for distinguishing subgroups. Journal of Learning Disabilities, 33(3), 297–307.
Booth, J. R., Cho, S., Burman, D. D., & Bitan, T. (2007). Neural correlates of mapping from phonology to orthography in children performing an auditory spelling task. Developmental Science, 10(4), 441–451.
Bowyer, S., Mason, K., Tepley, N., Smith, B., & Barkley, G. (2003). Magnetoencephalographic validation parameters for clinical evaluation of interictal epileptic activity. Journal of Clinical Neurophysiology, 20(2), 87–93.
Brady, S., & Shankweiler, D. (1991). Phonological processes in literacy: A tribute to Isabelle Liberman. Hillsdale: Lawrence Earlbaum.
Breier, J. I., Simos, P. G., Zouridakis, G., & Papanicolaou, A. C. (1998). Relative timing of neuronal activity in distinct temporal lobe areas during a recognition memory task for words. Journal of Clinical and Experimental Neuropsychology, 20(6), 782–790.
Breier, J. I., Simos, P. G., Zouridakis, G., Wheless, J. W., Willmore, L. J., Constantinou, J. E., et al. (1999a). Language dominance determined by magnetic source imaging: A comparison with the Wada procedure. Neurology, 53(5), 938–945.
Breier, J. I., Simos, P. G., Zouridakis, G., & Papanicolaou, A. C. (1999b). Temporal course of regional brain activation associated with phonological decoding. Journal of Clinical and Experimental Neuropsychology, 21(4), 465–476.
Coltheart, M., Curtis, B., Atkins, P., & Haller, M. (1993). Models of reading aloud: Dual-route and paralleldistributed-processing approaches. Psychological Review, 100(4), 589–608.
Dale, A. M., & Sereno, M. I. (1993). Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: A linear approach. Journal of Cognitive Neuroscience, 5, 162–176.
Damasio, H. (1995). Human brain anatomy in computerized images. New York: Oxford University Press.
Damasio, H., & Damasio, A. R. (1989). Lesion analysis in neuropsychology. New York: Oxford University Press.
Denton, C. A., Fletcher, J. M., Anthony, J. L., & Francis, D. J. (2006). An evaluation of intensive intervention for students with persistent reading difficulties. Journal of Learning Disabilities, 39(5), 447–466.
Eden, G. F., Jones, K. M., Cappell, K., Gareau, L., Wood, F. B., Zeffiro, T. A., et al. (2004). Neural changes following remediation in adult developmental dyslexia. Neuron, 44(3), 411–422.
Fiebach, C. J., Friederici, A. D., Muller, K., & von Cramon, D. Y. (2002). fMRI evidence for dual routes to the mental lexicon in visual word recognition. Journal of Cognitive Neuroscience, 14(1), 11–23.
Fletcher, J. M., Lyon, G. R., Fuchs, L. S., & Barnes, M. A. (2007). Learning disabilities: From identification to intervention. New York: The Guildford Press.
Gençer, N. G., Acar, C. E., & Tanzer, I. O. (2003). Forward problem solution of magnetic source imaging. In Z.-L. Lu & L. Kaufman (Eds.), Magnetic source imaging of the human brain (pp. 77–100). Mahwah: Lawrence Erlbaum Associates Inc.
Hagoort, P., Indefrey, P., Brown, C., Herzog, H., Steinmetz, H., & Seitz, R. J. (1999). The neural circuitry involved in the reading of German words and pseudowords: A PET study. Journal of Cognitive Neuroscience, 11(4), 383–398.
Hämäläinen, M. S., & Ilmoniemi, R. J. (1994). Interpreting magnetic fields of the brain: Minimum norm estimates. Medical & Biological Engineering & Computing, 32(1), 35–42.
Hämäläinen, M., & Sarvas, J. (1987). Feasibility of the homogeneous head model in the interpretation of neuromagnetic fields. Physics in Medicine and Biology, 32, 91–98.
Haueisen, J., Ramon, C., Czapski, P., & Eiselt, M. (1995). On the influence of volume currents and extended sources on neuromagnetic fields: A simulation study. Annals of Biomedical Engineering, 23(6), 728–739.
Haueisen, J., Ramon, C., Eiselt, M., Brauer, H., & Nowak, H. (1997). Influence of tissue resistivities on neuromagnetic fields and electric potentials studied with a finite element model of the head. IEEE Transactions on Biomedical Engineering, 44(8), 727–735.
Hillebrand, A., & Barnes, G. R. (2002). A quantitative assessment of the sensitivity of whole-head MEG to activity in the adult human cortex. NeuroImage, 16(3 Pt 1), 638–650.
Ihnot, C., Matsoff, J., & Gavin, J. (2001). Read naturally. St. Paul: Read Naturally, Inc.
Knowlton, R., Laxer, K., Aminoff, M., Roberts, T., Wong, S., & Rowley, H. (1997). Magnetoencephalography in partial epilepsy: Clinical yield and localization accuracy. Annals of Neurology, 42(4), 622–631.
Kujala, J., Pammer, K., Cornelissen, P., Roebroeck, A., Formisano, E., & Salmelin, R. (2007). Phase coupling in a cerebro-cerebellar network at 8–13 Hz during reading. Cerebral Cortex, 17(6), 1476–1485.
Kwon, H., Lee, Y. H., Kim, J. M., Park, Y. K., & Kuriki, S. (2002). Localization accuracy of single current dipoles from tangential components of auditory evoked fields. Physics in Medicine and Biology, 47(23), 4145–4154.
Laasonen, M., Lehtinen, M., Leppamaki, S., Tani, P., & Hokkanen, L. (2009). Project DyAdd: Phonological processing, reading, spelling, and arithmetic in adults with dyslexia or ADHD. Journal of Learning Disabilities, 43(1), 3–14.
Lalancette, M., Quraan, M., & Cheyne, D. (2011). Evaluation of multiple-sphere head models for MEG source localization. Physics in Medicine and Biology, 56(17), 5621–5635.
Lu, Z. L., & Williamson, S. J. (1991). Spatial extent of coherent sensory-evoked cortical activity. Experimental Brain Research, 84(2), 411–416.
Maestu, F., Ortiz, T., Fernandez, A., Amo, C., Martin, P., Fernandez, S., et al. (2002). Spanish language mapping using MEG: A validation study. NeuroImage, 17(3), 1579–1586.
Mamelak, A., Lopez, N., Akhtari, M., & Sutherling, W. (2002). Magnetoencephalography-directed surgery in patients with neocortical epilepsy. Journal of Neurosurgery, 97(4), 865–873.
McGuinness, C., McGuinness, D., & McGuinness, G. (1996). Phono-Graphix: A new method for remediation reading difficulties. Annals of Dyslexia, 46, 73–96.
Meyler, A., Keller, T. A., Cherkassky, V. L., Gabrieli, J. D., & Just, M. A. (2008). Modifying the brain activation of poor readers during sentence comprehension with extended remedial instruction: A longitudinal study of neuroplasticity. Neuropsychologia, 46(10), 2580–2592.
Moran, J. E., & Tepley, N. (2000). Two dimensional inverse imaging (2DII) of current sources in magnetoencephalography. Brain Topography, 12(3), 201–217.
Mosher, J. C., Baillet, S., & Leahy, R. M. (1999). EEG source localization and imaging using multiple signal classification approaches. Journal of Clinical Neurophysiology, 16(3), 225–238.
Murro, A. M., Smith, J. R., King, D. W., & Park, Y. D. (1995). Precision of dipole localization in a spherical volume conductor: A comparison of referential EEG, magnetoencephalography and scalp current density methods. Brain Topography, 8(2), 119–125.
Okada, Y. C., Wu, J., & Kyuhou, S. (1997). Genesis of MEG signals in a mammalian CNS structure. Electroencephalography and Clinical Neurophysiology, 103(4), 474–485.
Papanicolaou, A. C. (2009). Clinical magnetoencephalography and magnetic source imaging. New York: Cambridge University Press.
Papanicolaou, A. C., Simos, P. G., Breier, J. I., Fletcher, J. M., Foorman, B. R., Francis, D., et al. (2003). Brain mechanisms for reading in children with and without dyslexia: A review of studies of normal development and plasticity. Developmental Neuropsychology, 24(2–3), 593–612.
Papanicolaou, A. C., Simos, P. G., Castillo, E. M., Breier, J. I., Sarkari, S., Pataraia, E., et al. (2004). Magnetocephalography: A noninvasive alternative to the Wada procedure. Journal of Neurosurgery, 100(5), 867–876.
Papanicolaou, A. C., Pazo-Alvarez, P., Castillo, E. M., Billingsley-Marshall, R. L., Breier, J. I., Swank, P. R., et al. (2006). Functional neuroimaging with MEG: Normative language profiles. NeuroImage, 33(1), 326–342.
Pataraia, E., Simos, P. G., Castillo, E. M., Billingsley-Marshall, R. L., McGregor, A. L., Breier, J. I., et al. (2004). Reorganization of language-specific cortex in patients with lesions or mesial temporal epilepsy. Neurology, 63(10), 1825–1832.
Pazo-Alvarez, P., Simos, P. G., Castillo, E. M., Juranek, J., Passaro, A. D., & Papanicolaou, A. C. (2008). MEG correlates of bimodal encoding of faces and persons’ names. Brain Research, 1230, 192–201.
Pennington, B. F. (2008). Diagnosing learning disorders: A neuropsychological framework (2nd ed.). New York: The Guildford Press.
Pennington, B. F., McGrath, L. M., Rosenberg, J., Barnard, H., Smith, S. D., Willcutt, E. G., et al. (2009). Gene X environment interactions in reading disability and attention-deficit/hyperactivity disorder. Developmental Psychology, 45(1), 77–89.
Pugh, K. R., Mencl, W. E., Jenner, A. R., Katz, L., Frost, S. J., Lee, J. R., et al. (2000). Functional neuroimaging studies of reading and reading disability (developmental dyslexia). Mental Retardation and Developmental Disabilities Research Reviews, 6(3), 207–213.
Pugh, K. R., Frost, S. J., Sandak, R., Landi, N., Rueckl, J. G., Constable, R. T., et al. (2008). Effects of stimulus difficulty and repetition on printed word identification: An fMRI comparison of nonimpaired and reading-disabled adolescent cohorts. Journal of Cognitive Neuroscience, 20(7), 1146–1160.
Rezaie, R., Simos, P. G., Fletcher, J. M., Juranek, J., Cirino, P. T., Li, Z., Passaro, A. D., Sarkar, I. S., & Papanicolaou, A. C. (2011). The timing of regional brain activation associated with word recognition in children with reading difficulties. Frontiers in Human Neuroscience, 5, 45.
Rieben, L., & Perfetti, C. A. (1991). Learning to read: Basic research and its implications. Hillsdale: Lawrence Earlbaum.
Roux, F. E., Lubrano, V., Lauwers-Cances, V., Tremoulet, M., Mascott, C. R., & Demonet, J. F. (2004). Intra-operative mapping of cortical areas involved in reading in mono- and bilingual patients. Brain, 127(Pt 8), 1796–1810.
Salmelin, R., & Kujala, J. (2006). Neural representation of language: Activation versus long-range connectivity. Trends in Cognitive Science, 10(11), 519–525.
Shankweiler, D., Crain, S., Katz, L., Fowler, A. E., Liberman, A. M., Brady, S. A., et al. (1995). Cognitive profiles of reading-disabled children: Comparison of language skills in phonology, morphology, and syntax. Psychological Science, 6(3), 149–156.
Shaywitz, B. A., Shaywitz, S. E., Pugh, K. R., Mencl, W. E., Fulbright, R. K., Skudlarski, P., et al. (2002). Disruption of posterior brain systems for reading in children with developmental dyslexia. Biological Psychiatry, 52(2), 101–110.
Shaywitz, B. A., Shaywitz, S. E., Blachman, B. A., Pugh, K. R., Fulbright, R. K., Skudlarski, P., et al. (2004). Development of left occipitotemporal systems for skilled reading in children after a phonologically-based intervention. Biological Psychiatry, 55(9), 926–933.
Simos, P. G., Breier, J. I., Maggio, W. W., Gormley, W. B., Zouridakis, G., Willmore, L. J., et al. (1999a). Atypical temporal lobe language representation: MEG and intraoperative stimulation mapping correlation. Neuroreport, 10(1), 139–142.
Simos, P. G., Papanicolaou, A. C., Breier, J. I., Wheless, J. W., Constantinou, J. E., Gormley, W. B., et al. (1999b). Localization of language-specific cortex by using magnetic source imaging and electrical stimulation mapping. Journal of Neurosurgery, 91(5), 787–796.
Simos, P. G., Breier, J. I., Wheless, J. W., Maggio, W. W., Fletcher, J. M., Castillo, E. M., et al. (2000a). Brain mechanisms for reading: The role of the superior temporal gyrus in word and pseudoword naming. Neuroreport, 11(11), 2443–2447.
Simos, P. G., Breier, J. I., Fletcher, J. M., Bergman, E., & Papanicolaou, A. C. (2000b). Cerebral mechanisms involved in word reading in dyslexic children: A magnetic source imaging approach. Cerebral Cortex, 10(8), 809–816.
Simos, P. G., Breier, J. I., Fletcher, J. M., Foorman, B. R., Bergman, E., Fishbeck, K., et al. (2000c). Brain activation profiles in dyslexic children during non-word reading: A magnetic source imaging study. Neuroscience Letters, 290(1), 61–65.
Simos, P. G., Breier, J. I., Fletcher, J. M., Foorman, B. R., Mouzaki, A., & Papanicolaou, A. C. (2001) Age-related changes in regional brain activation during phonological decoding and printed word recognition. Developmental Neuropsychology, 19(2), 191–210.
Simos, P. G., Fletcher, J. M., Bergman, E., Breier, J. I., Foorman, B. R., Castillo, E. M., et al. (2002a). Dyslexia-specific brain activation profile becomes normal following successful remedial training. Neurology, 58(8), 1203–1213.
Simos, P. G., Breier, J. I., Fletcher, J. M., Foorman, B. R., Castillo, E. M., & Papanicolaou, A. C. (2002b). Brain mechanisms for reading words and pseudowords: An integrated approach. Cerebral Cortex, 12(3), 297–305.
Simos, P. G., Fletcher, J. M., Sarkari, S., Billingsley, R. L., Francis, D. J., Castillo, E. M., et al. (2005). Early development of neurophysiological processes involved in normal reading and reading disability: A magnetic source imaging study. Neuropsychology, 19(6), 787–798.
Simos, P. G., Fletcher, J. M., Sarkari, S., Billingsley, R. L., Denton, C., & Papanicolaou, A. C. (2007a). Altering the brain circuits for reading through intervention: A magnetic source imaging study. Neuropsychology, 21(4), 485–496.
Simos, P. G., Fletcher, J. M., Sarkari, S., Billingsley-Marshall, R., Denton, C. A., & Papanicolaou, A. C. (2007b). Intensive instruction affects brain magnetic activity associated with oral word reading in children with persistent reading disabilities. Journal of Learning Disabilities, 40(1), 37–48.
Simos, P. G., Pugh, K., Mencl, E., Frost, S., Fletcher, J. M., Sarkari, S., et al. (2009). Temporal course of word recognition in skilled readers: A magnetoencephalography study. Behavioural Brain Research, 197(1), 45–54.
Simos, P. G., Rezaie, R., Fletcher, J. M., Juranek, J., Passaro, A. P., Li, Z., Cirino, P. T., et al. (2011). Functional disruption of the brain mechanism for reading: Effects of comorbidity and task difficulty among children with developmental learning problems. Neuropsychology, 25(4), 520–534.
Temple, E., Deutsch, G. K., Poldrack, R. A., Miller, S. L., Tallal, P., Merzenich, M. M., et al. (2003). Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI. Proceedings of the National Academy of Sciences of the United States of America, 100(5), 2860–2865.
Turkeltaub, P. E., Eden, G. F., Jones, K. M., & Zeffiro, T. A. (2002). Meta-analysis of the functional neuroanatomy of single-word reading: Method and validation. NeuroImage, 16(3 Pt 1), 765–780.
Valaki, C. E., Maestu, F., Simos, P. G., Zhang, W., Fernandez, A., Amo, C. M., et al. (2004). Cortical organization for receptive language functions in Chinese, English, and Spanish: A cross-linguistic MEG study. Neuropsychologia, 42(7), 967–979.
Wang, J.-Z., & Kaufman, L. (2003). Magnetic source imaging: Search for inverse solutions. In Z.-L. Lu & L. Kaufman (Eds.), Magnetic source imaging of the human brain (pp. 101–134). Mahwah: Lawrence Erlbaum Associates, Inc.
Willcutt, E. G., Pennington, B. F., Olson, R. K., & DeFries, J. C. (2007). Understanding comorbidity: A twin study of reading disability and attention-deficit/hyperactivity disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 144B(6), 709–714.
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Rezaie, R., Simos, P.G., Fletcher, J.M., Denton, C., Papanicolaou, A.C. (2012). Magnetic Source Imaging: A Suitable Tool of Exploring the Neurophysiology of Typical and Impaired Reading Ability. In: Breznitz, Z., Rubinsten, O., Molfese, V., Molfese, D. (eds) Reading, Writing, Mathematics and the Developing Brain: Listening to Many Voices. Literacy Studies, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4086-0_3
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