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Gene Expression and Epigenetic Signatures of Germ Cell-Derived Pluripotent Stem Cells and Embryonic Stem Cells

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Book cover Stem Cells and Cancer Stem Cells, Volume 6

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 6))

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Abstract

Germ cell-derived Pluripotent Stem Cells (gPSCs) are pluripotent stem cells that originate from Spermatogonial Stem Cells (SSCs) of the testis. Several reports in the last few years have shown that it is possible to isolate and enrich the SSC population by different approaches and even reprogram these in vivo multipotent cells to gPSCs in vitro. As these cells could be an alternative to circumvent the ethical objections regarding the use of Embryonic Stem Cells (ESCs) for therapeutic approaches, these SSC-derived gPSCs were characterized in several studies comparatively to the gold standard of pluripotency, the ESCs. The results ­provide great promise that gPSCs can be of importance for practical use in regenerative medicine.

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Authors and Affiliations

  1. Institut für Humangenetik, Universitätsmedizin Göttingen (UMG), Heinrich-Düker-Weg 12, 37073, Göttingen, Germany

    Jessica Nolte & D. V. Krishna Pantakani

  2. Abteilung Nephrologie und Rheumatologie, Universitätsmedizin Göttingen (UMG), Robert-Koch-Str. 40, 37075, Göttingen, Germany

    Hassan Dihazi

  3. Institut für Humangenetik, Universitätsmedizin der, Johannes Gutenberg-Universität, Langenbeckstr. 1, 55101, Mainz, Germany

    Ulrich Zechner

Authors
  1. Jessica Nolte
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  2. D. V. Krishna Pantakani
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  3. Hassan Dihazi
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  4. Ulrich Zechner
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Corresponding author

Correspondence to Ulrich Zechner .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Nolte, J., Pantakani, D.V.K., Dihazi, H., Zechner, U. (2012). Gene Expression and Epigenetic Signatures of Germ Cell-Derived Pluripotent Stem Cells and Embryonic Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 6. Stem Cells and Cancer Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2993-3_3

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