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Tumors of the Central Nervous System, Volume 7 pp 179–189Cite as

Genetic and Clinical Features Associated with Recurrence in Atypical Meningioma

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Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 7))

Abstract

Up to 40% of meningiomas correspond to non-benign subtypes associated with two-fold increased relative risk of local failure and four-fold relative excess risk of death. Among them atypical grade II meningiomas comprise over 90% of cases and exhibit heterogeneous clinical outcomes. Several recent studies have performed detailed clinical and molecular-genetic characterization of these neoplasms in order to clarify their pathogenesis and elucidate potential predictive, prognostic and therapeutic markers that may help guide clinical management. Results of these investigations have implicated gain of genetic material on chromosome 1q with increased recurrence and/or progression of tumor and have identified associations of bone involvement with both progression and death in atypical meningioma. Important future challenges in meningioma research include the investigation of large-scale and focal genomic alterations in multi-institutional collaborations and the assessment of whether more thorough bone assessment and bone-directed treatment can improve the heterogeneous outcomes in the unpredictable atypical subtype of the disease.

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Authors and Affiliations

  1. Department of Radiation Oncology, Albert Einstein College of Medicine of the Yeshiva University, Montefiore Medical Center, Bronx, NY, USA

    Darlene Gabeau & Yvonne W. Lui

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  1. Darlene Gabeau
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  2. Yvonne W. Lui
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Correspondence to Darlene Gabeau .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Gabeau, D., Lui, Y.W. (2012). Genetic and Clinical Features Associated with Recurrence in Atypical Meningioma. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 7. Tumors of the Central Nervous System, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2894-3_20

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  • DOI: https://doi.org/10.1007/978-94-007-2894-3_20

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