Abstract
The explosive, warfare agent, and toxin worldwide threats are important hazardous determinants for a safe living environment. The need for better methods of determinations of these compounds generates a strong demand for sensitive, selective, and fast sensing systems. Typically, biorecognition receptors, like enzymes or antibodies, are used to devise biosensors for selective determinations of these compounds. However, these biosensors suffer from several deficiencies. Therefore, synthetic receptors, and particularly those using the concept of molecular imprinting, are more and more often being devised as alternatives of the bioreceptors. Among them, the most popular now are molecularly imprinted materials. The present chapter critically evaluates achievements in the development of chemosensing using the imprinting idea for selective determination of biohazardous compounds. Different methods of preparation of synthetic imprinted recognition receptors are scrutinized and various platforms of analytical signal transduction are assessed.
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Abbreviations
- AAm:
-
acrylamide
- ACN:
-
acetonitrile
- ACCN:
-
EGDMA/1,1´-azobis(cyclohexane carbonitrile)
- AgNP:
-
silver nanoparticle
- AIBN:
-
azobis isobutyronitrile
- APBA:
-
3-aminophenylboronic acid
- APh:
-
2-aminophenol
- APTMS:
-
3-aminopropyl trimethoxysilane
- 2-AThPh:
-
2-aminothiophenol
- 4-AThPh:
-
4-aminothiophenol
- ATRS:
-
attenuated total reflectance spectroscopy
- AuNP:
-
gold nanoparticle
- BTEB:
-
bis(trimethoxysilylethyl)benzene
- BWA:
-
biological warfare agent
- CP:
-
conducting polymer
- CV:
-
cyclic voltammetry
- DMF:
-
N,N-dimethylformamide
- DPV:
-
differential pulse voltammetry
- ECP:
-
electronically conducting polymer
- EGDMA:
-
ethylene glycol dimethacrylate
- ELISA:
-
enzyme-linked immunosorbent assay
- GA:
-
glutaraldehyde
- GCE:
-
glassy carbon electrode
- HEPES:
-
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
- HMPA:
-
hexamethylphosphoramide
- IA:
-
itaconic acid
- ITMS:
-
iodotrimethylsilane
- ITO:
-
indium-tin oxide
- IOW:
-
integrated optical waveguide
- LBL:
-
layer-by-layer (transfer)
- LOD:
-
limit of detection
- LSV:
-
linear sweep voltammetry
- MA:
-
methacrylic acid
- MIECP:
-
molecularly imprinted electronically conducting polymer
- MIP:
-
molecularly imprinted polymer
- MIPAPBA:
-
molecularly imprinted poly(aminophenylboronic acid)
- MIPEDOT:
-
molecularly imprinted poly ethylenedioxythiophene
- MIPPy:
-
molecularly imprinted polypyrrole
- NIP:
-
non-imprinted polymer
- NOPE:
-
2-nitrophenyloctyl ether
- OTS:
-
octadecylsiloxane
- PANI:
-
polyaniline
- PBS:
-
phosphate buffer saline
- PM:
-
piezoelectric microgravimetry
- PPV:
-
poly(4-phenylene vinylene)
- PVC:
-
poly(vinyl chloride)
- Py:
-
pyrrole
- SAM:
-
self-assembled monolayer
- SCE:
-
saturated calomel electrode
- SDS:
-
sodium dodecyl sulfate
- SERS:
-
surface enhanced Raman scattering
- SPE:
-
solid phase extraction
- SPME:
-
solid phase microextraction
- SPR:
-
surface plasmon resonance
- SWV:
-
square wave voltammetry
- TEOS:
-
tetraethoxysilane
- TMSEPyr:
-
2-(trimethoxysilylethyl)pyridine
- G :
-
Gibbs free energy
- H :
-
enthalpy
- KMIP-A:
-
stability constant of a complex of the analyte A and the molecular cavity of MIP
- S :
-
entropy
- q :
-
resonance angle
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Acknowledgments
PSS and WK thank the European Regional Development Fund (Project ERDF, POIG.01.01.02-00-008/08 2007–2013, to WK). The work of WK was partially realized within the International PhD Projects Programme of the Foundation for Polish Science, co-financed from European Regional Development Fund within Innovative Economy Operational Program “Grants for innovation”. FD is thankful to the National Science Foundation for the financial support.
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Sharma, P.S., Kutner, W., D’Souza, F. (2012). Molecular Imprinting for Selective Sensing of Explosives, Warfare Agents, and Toxins. In: Nikolelis, D. (eds) Portable Chemical Sensors. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2872-1_4
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