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The Oxidative Phosphorylation System in Mammalian Mitochondria

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Advances in Mitochondrial Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 942))

Abstract

The chapter provides a review of the state of art of the oxidative phosphorylation system in mammalian mitochondria. The sections of the paper deal with:

  1. (i)

    the respiratory chain as a whole: redox centers of the chain and protonic coupling in oxidative phosphorylation

  2. (ii)

    atomic structure and functional mechanism of protonmotive complexes I, III, IV and V of the oxidative phosphorylation system

  3. (iii)

    biogenesis of oxidative phosphorylation complexes: mitochondrial import of nuclear encoded subunits, assembly of oxidative phosphorylation complexes, transcriptional factors controlling biogenesis of the complexes.

This advanced knowledge of the structure, functional mechanism and biogenesis of the oxidative phosphorylation system provides a background to understand the pathological impact of genetic and acquired dysfunctions of mitochondrial oxidative phosphorylation.

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Acknowledgements

This work was supported by: National Project, “Progetto FIRB Rete Nazionale per lo Studio della Proteomica Umana (Italian Human ProteomeNet)”, 2009, Ministero dell’ Istruzione, dell’Università e della Ricerca (MIUR) and University of Bari Research grant, 2009.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Section of Medical Biochemistry, University of Bari, Policlinico, P.zza G. Cesare, 70124, Bari, Italy

    Sergio Papa, Pietro Luca Martino, Giuseppe Capitanio, Domenico De Rasmo, Anna Signorile & Vittoria Petruzzella

  2. Institute of Biomembranes and Bioenergetics (IBBE), Italian Research Council, (CNR), Bari, Italy

    Sergio Papa, Antonio Gaballo, Domenico De Rasmo & Vittoria Petruzzella

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  1. Sergio Papa
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Correspondence to Sergio Papa .

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  1. School of Medicine, Institute of Biochemistry and Clinical B, Catholic University, Largo A. Gemelli 8, Rome, 00168, Italy

    Roberto Scatena

  2. School of Medicine, Institute of Biochemistry and Clinical B, Catholic University, Largo A. Gemelli 8, Rome, 00168, Italy

    Patrizia Bottoni

  3. School of Medicine, Institute of Biochemistry and Clinical B, Catholic University, Largo A. Gemelli 8, Rome, 00168, Italy

    Bruno Giardina

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Papa, S. et al. (2012). The Oxidative Phosphorylation System in Mammalian Mitochondria. In: Scatena, R., Bottoni, P., Giardina, B. (eds) Advances in Mitochondrial Medicine. Advances in Experimental Medicine and Biology, vol 942. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2869-1_1

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