Abstract
The basic idea of multistage regression goes back to the early thirtieth when Sewal Wright, professor of economics at the University of Chicago, described direct and indirect predictors (Wright 1928). If you want to predict the price of vegetables, then the weather-reports seemed to be a better predictor than problematic information about the crops (Wright 1928). Indirect predictors are defined as instrumental variables that come from a detailed knowledge of the underlying mechanisms determining both the predictor and the outcome (Angrist and Krueger 2001). They are widely applied in economics, but in the past years a few studies on health statistics have been published: cigarette tax, counselling, proximity of health facility better predicted health outcomes than did direct causal factors (Evans and Ringel 1999; Permutt and Hebel 1989; McClellan et al. 1994).
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Angrist JD, Krueger AB (2001) Instrumental variables and the search for identification: from supply and demand to natural experiments. J Econ Perspect 15:69–85
Barone P, Poewe W, Albrecht S, Debleuve C, Massey D, Rascol O, Tolosa E, Weintraub D (2010) Pramipexole for the treatments of depressive symptoms in patients with Parkinson’s disease: a double blind placebo controlled trial. Lancet Neurol 9:573–580
Evans W, Ringel J (1999) Can higher cigarette taxes improve birth outcomes? J Public Econ 72:135–154
Eyler FD, Warner TD, Behnke M, Hou W, Wobie K, Wilson GC (2009) Executive functioning at ages 5 and 7 years in children with prenatal cocaine exposure. Dev Neurosci 31:121–136
Gibbons RD, Maas JW, Davis JM, Swann AC, Redmond DE, Casper RC, Hanin I, Bowden CL, Kocsis J, Stokes PE (1986) Path analysis of psychopharmacological data: catecholamine breakdown in man. Psychiatr Res 18:89–105
McClellan M, McNeil B, Newhouse JP (1994) Does more intensive treatment of acute myocardial infarction in the elderly reduce mortality? JAMA 272:859–866
Meltzer H, Arato M, Connor O (2000) Path analysis of the ZEUS study provides evidence of direct effect of ziprasidone on primary negative symptoms in chronic stable schizophrenia. Schizophr Res 41(Special Iss 1):B 91
Morris MS (2010) Opioid modulation of oxytocin release. J Clin Pharmacol 50:1112–1117
O’Reilly KC, Shumake J, Bailey SJ, Gonzalez-Lima F, Lane MA (2009) Chronic 13-cis-retinoid acid administration disrupts network interactions between the raphne nuclei and the hippocampal system in young adult mice. Eur J Pharmacol 605:68–77
Permutt T, Hebel JR (1989) Simultaneous estimation in a clinical trial of the effect of smoking on birth weight. Biometrics 45:619–622
Qiu L (2007) Path analysis of biomarkers of exposure and early biologic effects among coke-oven workers exposed to polycyclic aromatic hydrocarbons. Cancer Epidemiol Biomark Rev 16:1193–1199
SPSS statistical software. www.SPSS.com. Accessed 14 Dec 2011
Steiner E, Iselius L, Alvan G, Lindsten J, Sjoqvist F (1985) A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin. Clin Pharmacol Ther 38:394–401
Tollefson GD, Sanger TM (1997) Negative symptoms: a path analysis approach to a double Blind placebo and haloperidol controlled clinical trial with olanzapine. Am J Psychiatr 154:466–474
Wright S (1928) Appendix. In: Wright PC (ed) The tariff on animal and vegetable oils. Macmillan, New York
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Cleophas, T.J., Zwinderman, A.H. (2012). Multistage Regression. In: Statistics Applied to Clinical Studies. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2863-9_20
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DOI: https://doi.org/10.1007/978-94-007-2863-9_20
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