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Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles

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Acoustical Imaging

Part of the book series: Acoustical Imaging ((ACIM,volume 31))

Abstract

The destruction threshold of ultrasound contrast agents is an important parameter for safety and applications in targeted drug delivery. Since this threshold is a function of the chemical composition of lipid-shelled microbubbles, adjustment of this composition may allow tuning of the destruction threshold. To attain this goal, this study presents a framework for the analysis of the destruction threshold. A method for the theoretical determination of this threshold is presented. Theoretical results are subsequently validated by experiments, yielding a linear dependence between shell viscosity and elasticity and DSPE-PEG2000 concentration.

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Author information

Authors and Affiliations

  1. Institute of Medical Engineering, Ruhr-Universität Bochum, Bochum, Germany

    Michał Mleczko & Georg Schmitz

  2. Department of Chemical Engineering, Drexel University, Philadelphia, PA, 19103, USA

    Stephen M. Dicker & Steven P. Wrenn

Authors
  1. Michał Mleczko
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  2. Stephen M. Dicker
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  3. Steven P. Wrenn
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  4. Georg Schmitz
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Corresponding author

Correspondence to Michał Mleczko .

Editor information

Editors and Affiliations

  1. Polish Academy of Sciences, IPPT, Pawinskiego 5 b, Warszawa, 02-106, Poland

    Andrzej Nowicki

  2. , Inst. Fundamental Technological Research, Polish Academy of Sciences, IPPT, Pawinskiego 5 b, Warszawa, 02-106, Poland

    Jerzy Litniewski

  3. Polish Academy of Sciences, IPPT, Pawinskiego 5 b, Warszawa, 02-106, Poland

    Tamara Kujawska

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Mleczko, M., Dicker, S.M., Wrenn, S.P., Schmitz, G. (2012). Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles. In: Nowicki, A., Litniewski, J., Kujawska, T. (eds) Acoustical Imaging. Acoustical Imaging, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2619-2_10

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  • DOI: https://doi.org/10.1007/978-94-007-2619-2_10

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-2618-5

  • Online ISBN: 978-94-007-2619-2

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