Abstract
The destruction threshold of ultrasound contrast agents is an important parameter for safety and applications in targeted drug delivery. Since this threshold is a function of the chemical composition of lipid-shelled microbubbles, adjustment of this composition may allow tuning of the destruction threshold. To attain this goal, this study presents a framework for the analysis of the destruction threshold. A method for the theoretical determination of this threshold is presented. Theoretical results are subsequently validated by experiments, yielding a linear dependence between shell viscosity and elasticity and DSPE-PEG2000 concentration.
Keywords
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Epstein, P.S., Plesset, M.S.: On the stability of gas bubbles in liquid-gas solutions. J. Chem. Phys. 18, 1505–1509 (1950)
Borden, M.A., Kruse, D.E., Caskey, C., Zhao, S., Dayton, P.A., Ferrara, K.W.: Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52(11), 1992–2002 (2005)
Apfel, R.E., Holland, C.K.: Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound. Ultrasound Med. Biol. 17(2), 179–185 (1991)
Church, C.: Frequency, pulse length, and the mechanical index. Acoust. Res. Lett. Online 6(3), 162–168 (2005)
Ammi, A. Y., Mamou, J., Wang, G. I., Cleveland, R. O., Bridal, S. L., O’Brien, W. D.: Determining thresholds for contrast agent collapse. Proc. IEEE Ultrason. Symp., 346–349 (2004)
Ammi, A.Y., Cleveland, R.O., Mamou, J., Wang, G.I., Bridal, S.L., O’Brien, W.D.: Ultrasonic contrast agent shell rupture detected by inertial cavitation and rebound signals. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 53(1), 126–136 (2006)
Forbes, M., O’Brien, W. D.: The role of inertial cavitation of ultrasound contrast agents in producing sonoporation [sic]. Proc. IEEE Ultrason. Symp., 424–427 (2007)
Hallow, D.M., Mahajan, A., McCutchen, T., Prausnitz, M.R.: Measurement and correlation of acoustic cavitation with cellular bioeffects. Ultrasound Med. Biol. 32(7), 1111–1122 (2006)
Hensel, K., Siepmann, M., Schmitz, G., Maghnouj, A., Hahn, S.: Monitoring and modeling of microbubble behavior during ultrasound mediated transfection of cell monolayers. Proc. IEEE Ultrason. Symp., 1671–1674 (2008)
Chou, T., Chu, I.: Behavior of DSPC/DSPE-PEG2000 mixed monolayers at the air/water interface. Colloid Surf. A 211(2–3), 267–274 (2002)
Klibanov, A.L.: Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging. Bioconjug. Chem. 16(1), 9–17 (2005)
Wrenn, S.P., Mleczko, M., Schmitz, G.: Phospholipid-stabilized microbubbles: influence of shell chemistry on cavitation threshold and binding to giant uni-lamellar vesicles. Appl. Acoust. 70(10), 1313–1322 (2009)
Flynn, H.G.: Cavitation dynamics. I. A mathematical formulation. J. Acoust. Soc. Am. 57, 1379 (1975)
Flynn, H.G.: Cavitation dynamics: II. Free pulsations and models for cavitation bubbles. J. Acoust. Soc. Am. 58, 1160 (1975)
Leighton, T.G.: The Acoustic Bubble. Academic, London (1997)
Vaughan, P. Leeman, S.: Sonoluminescence: violent light or gentle glow? Proc. IEEE Ultrason. Symp., 989–992 (1986)
Morgan, K.E., Allen, J.S., Dayton, P.A., Chomas, J.E., Klibanov, A.L., Ferrara, K.W.: Experimental and theoretical evaluation of microbubble behavior: effect of transmitted phase and bubble size. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 47(6), 1494–1509 (2000)
Mleczko, M., Schmitz, G.: An experimental setup for the determination of the inertial cavitation threshold of ultrasound contrast agents. Proc. IEEE Int. Ultrason. Symp., 1686–1689 (2008)
Simpson, D.H., Chin, C.T., Burns, P.N.: Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46(2), 372–382 (1999)
Evans, E., Rawicz, W.: Elasticity of “fuzzy” biomembranes. Phys. Rev. Lett. 79(12), 2379–2382 (1997)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media B.V.
About this paper
Cite this paper
Mleczko, M., Dicker, S.M., Wrenn, S.P., Schmitz, G. (2012). Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles. In: Nowicki, A., Litniewski, J., Kujawska, T. (eds) Acoustical Imaging. Acoustical Imaging, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2619-2_10
Download citation
DOI: https://doi.org/10.1007/978-94-007-2619-2_10
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-2618-5
Online ISBN: 978-94-007-2619-2
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)