Abstract
Success of dental implant materials depends on their integration into the adjacent soft and hard tissues where critical interactions take place at the interface between the surface of the metal and the biological components. The properties of the dental implant surface, such as surface morphology, surface energy, and chemistry affect cell responses and tissue regeneration. Therefore, modifications of the surfaces of the implant to minimize the nonspecific adsorption of proteins and to mediate bone osseointegration and tissue healing are research subjects of major interest. One promising approach consists of functionalizing dental implant materials by incorporating biological molecules with known bioactivities. Bioactive components such as extracellular matrix proteins, growth factors, and peptides have been covalently immobilized on surfaces to investigate their potential benefit in the clinical success of dental implants. The immobilization by means of primary bonds between the surface and the biomolecules can enhance stability and retention of the biomolecules on the implant and preserve biological activity compared to physically adsorbed molecules. We introduce here methodologies to covalently anchor biomolecules on the surface of dental implants. We thoroughly review the chemical strategies and biomolecules used as well as their effects on different biological responses of interest, such as osteoblasts response to improve osseointegration, antimicrobial properties, and in vivo integration. The stable immobilization of biomolecules on implants to form a bioactive surface can be an effective and novel approach to achieve implantation success in all clinical scenarios.
Keywords
- Atom Transfer Radical Polymerization
- Atom Transfer Radical Polymerization
- Simulated Body Fluid
- Bioactive Molecule
- Dental Implant
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Brunski, J.B.: Classes of materials used in medicine. Metals. In: Rutner, B., Hoffman, A., Schoen, F., Lemons, J. (eds.) Biomaterials Science, an Introduction to Materials in Medicine. Academic Press, San Diego (1996)
Ratner, B.D.: A perspective on titanium biocompatibility. In: Brunette, D.M., Tengvall, P., Textor, M., Thomsen, P. (eds.) Titanium in medicine: Material science, surface science, engineering, biological responses and medical applications, pp. 1–12. Springer-Verlag, Berlin Heidelberg (2001)
Lindquist, L.W., Carlsson, G.E., Jemt, T.: A prospective 15-year follow-up study of mandibular fixed prostheses supported by osseointegrated implants—clinical results and marginal bone loss. Clin. Oral Implan. Res. 7, 329–336 (1996)
Schwartz-Arad, D., Kidron, N., Dolev, E.: A long-term study of implants supporting overdentures as a model for implant success. J. Periodontol. 76, 1431–1435 (2005)
Branemark, P.I., Hansson, B.O., Adell, R., et al.: Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scandinavian journal of plastic and reconstructive surgery. Supplementum 16, 1–132 (1977)
Bumgardner, J.D., Adatrow, P., Haggard, W.O., et al.: Emerging antibacterial biomaterial strategies for the prevention of peri-implant inflammatory diseases. Int. J. Oral. Max. Impl. 26, 553–560 (2011)
Le Guehennec, L., Soueidan, A., Layrolle, P., et al.: Surface treatments of titanium dental implants for rapid osseointegration. Dent. Mater. 23, 844–854 (2007)
Schliephake, H., Scharnweber, D.: Chemical and biological functionalization of titanium for dental implants. J. Mater. Chem. 18, 2404–2414 (2008)
Williams, D.F.: Titanium for medical applications. In: Brunette, D.M., Tengvall, P., Textor, M., Thomsen, P. (eds.) Titanium in Medicine: Material Science, Surface Science, Engineering, Biological Responses and Medical Applications, pp. 13–24. Springer-Verlag, Berlin Heidelberg
Kasemo, B.: Biological surface science. Surf. Sci. 500, 656–677 (2002)
Castner, D.G., Ratner, B.D.: Biomedical surface science: Foundations to frontiers. Surf. Sci. 500, 28–60 (2002)
Elmengaard, B., Bechtold, J.E., Soballe, K.: In vivo study of the effect of RGD treatment on bone ongrowth on press-fit titanium alloy implants. Biomaterials 26, 3521–3526 (2005)
Wang, H.L., Ormianer, Z., Palti, A., et al.: Consensus conference on immediate loading: The single tooth and partial edentulous areas. Implant Dent. 15, 324–333 (2006)
Puleo, D.A., Nanci, A.: Understanding and controlling the bone-implant interface. Biomaterials 20, 2311–2321 (1999)
Buser, D.: Titanium for dental applications (II): Implants with roughened surfaces. In: Brunette, D.M., Tengvall, P., Textor, M., Thomsen, P. (eds.) Titanium in Medicine: Material Science, Surface Science, Engineering, Biological Responses and Medical Applications, pp. 875–887. Springer-Verlag, Berlin Heidelberg (2001)
Klokkevold, P.R., Johnson, P., Dadgostari, S., et al.: Early endosseous integration enhanced by dual acid etching of titanium: a torque removal study in the rabbit. Clin. Oral Implan. Res. 12, 350–357 (2001)
Ivanoff, C.J., Hallgren, C., Widmark, G., et al.: Histologic evaluation of the bone integration of TiO2 blasted and turned titanium microimplants in humans. Clin. Oral. Implan. Res. 12, 128–134 (2001)
Sutter, F., Schroeder, A., Buser, D.A.: The new concept of ITI hollowcylinder and hollowscrew implants. Part 1. Engineering and design. Int. J. Oral Maxillofac. Implants. 3, 161–172 (1988)
Sul, Y.T., Johansson, C.B., Petronis, S., et al.: Characteristics of the surface oxides on turned and electrochemically oxidized pure titanium implants up to dielectric breakdown: the oxide thickness, micropore configurations, surface roughness, crystal structure and chemical composition. Biomaterials 23, 491–501 (2002)
Buser, D., Nydegger, T., Hirt, H.P., et al.: Removal torque values of titanium implants in the maxilla of miniature pigs. Int. J. Oral Maxillofac. Implants 13, 611–619 (1998)
Boyan, B.D., Hummert, T.W., Dean, D.D., et al.: Role of material surfaces in regulating bone and cartilage cell response. Biomaterials 17, 137–146 (1996)
Han, C.-H., Johansson, C.B., Wennerberg, A., et al.: Quantitative and qualitative investigations of surface enlarged titanium and titanium alloys implants. Clin. Oral Implan. Res. 9, 1–10 (1998)
Martin, J.Y., Schwartz, Z., Hummert, T.W., et al.: Effect of titanium surface-roughness on proliferation, differentiation, and protein-synthesis of human osteoblast-like cells (Mg63). J. Biomed. Mater. Res. 29, 389–401 (1995)
Pegueroles, M., Aparicio, C., Bosio, M., et al.: Spatial organization of osteoblasts fibronectin-matrix on titanium surface-effects of roughness, chemical heterogeneity, and surface free energy. Acta. Biomater. 6, 291–301 (2010)
Cochran, D.L., Schenk, R.K., Lussi, A., et al.: Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: A histometric study in the canine mandible. J. Biomed. Mater. Res. 40, 1–11 (1998)
Aparicio, C., Gil, F.J., Fonseca, C., et al.: Corrosion behaviour of commercially pure titanium shot blasted with different materials and sizes of shot particles for dental implant applications. Biomaterials 24, 263–273 (2003)
Pegueroles, M., Gil, F.J., Planell, J.A., et al.: The influence of blasting and sterilization on static and time-related wettability and surface-energy properties of titanium surfaces. Surf. Coat. Tech. 202, 3470–3479 (2008)
Mendonca, G., Mendonca, D.B.S., Aragao, F.J.L., et al.: Advancing dental implant surface technology—from micron- to nanotopography. Biomaterials 29, 3822–3835 (2008)
Variola, F., Brunski, J.B., Orsini, G., et al.: Nanoscale surface modifications of medically relevant metals: State-of-the art and perspectives. Nanoscale 3, 335–353 (2011)
Palmquist, A., Omar, O.M., Esposito, M., et al.: Titanium oral implants: surface characteristics, interface biology and clinical outcome. J. R. Soc. Interface 7, S515–S527 (2010)
Junker, R., Dimakis, A., Thoneick, M., et al.: Effects of implant surface coatings and composition on bone integration: a systematic review. Clin. Oral Implan. Res. 20, 185–206 (2009)
Rupp, F., Scheideler, L., Olshanska, N., et al.: Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J. Biomed. Mater. Res. A 76A, 323–334 (2006)
Schwarz, F., Herten, M., Sager, M., et al.: Bone regeneration in dehiscence-type defects at chemically modified (SLActive®) and conventional SLA titanium implants: A pilot study in dogs. J. Clin. Periodontol. 34, 78–86 (2007)
Zhao, G., Schwartz, Z., Wieland, M., et al.: High surface energy enhances cell response to titanium substrate microstructure. J. Biomed. Mater. Res. A 74A, 49–58 (2005)
Ueno, T., Yamada, M., Suzuki, T., et al.: Enhancement of bone-titanium integration profile with UV-photofunctionalized titanium in a gap healing model. Biomaterials 31, 1546–1557 (2010)
Borsari, V., Fini, M., Giavaresi, G., et al.: Osteointegration of titanium and hydroxyapatite rough surfaces in healthy and compromised cortical and trabecular bone: In vivo comparative study on young, aged, and estrogen-deficient sheep. J. Orthop. Res. 25, 1250–1260 (2007)
Geesink, R.G.T., Degroot, K., Klein, C.P.A.T.: Chemical implant fixation using hydroxyl-apatite coatings—the development of a human total hip-prosthesis for chemical fixation to bone using hydroxyl-apatite coatings on titanium substrates. Clin. Orthop. Relat. Res. 147–170 (1987)
Hulshoff, J.E., Hayakawa, T., Van Dijk, K., et al.: Mechanical and histologic evaluation of Ca-P plasma-spray and magnetron sputter-coated implants in trabecular bone of the goat. J. Biomed. Mater. Res. 36, 75–83 (1997)
Lee JR, L., Beirne, O.: Survival of hydroxypatite-coated implants: A meta-analytic review. J. Oral Maxillofac. Surg. 58, 1372–1379 (2000)
Kim, H.M., Miyaji, F., Kokubo, T., et al.: Preparation of bioactive Ti and its alloys via simple chemical surface treatment. J. Biomed. Mater. Res. 32, 409–417 (1996)
Li, P.J., Degroot, K.: Calcium-phosphate formation within sol-gel prepared Titania in-vitro and in-vivo. J. Biomed. Mater. Res. 27, 1495–1500 (1993)
Li, P.J., Ducheyne, P.: Quasi-biological apatite film induced by titanium in a simulated body fluid. J. Biomed. Mater. Res. 41, 341–348 (1998)
Ohtsuki, C., Iida, H., Hayakawa, S., et al.: Bioactivity of titanium treated with hydrogen peroxide solutions containing metal chlorides. J. Biomed. Mater. Res. 35, 39–47 (1997)
Wen, H.B., Dewijn, J.R., Liu, Q., et al.: A simple method to prepare calcium phosphate coatings on Ti6Al4 V. J. Mater. Sci. Mater. M 8, 765–770 (1997)
Kim, H.M., Miyaji, F., Kokubo, T., et al.: Preparation of bioactive Ti and its alloys via simple chemical surface treatment. J. Biomed. Mater. Res. 32, 409–417 (1996)
Kokubo, T., Takadama, H.: How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27, 2907–2915 (2006)
Nishiguchi, S., Kato, H., Fujita, H., et al.: Titanium metals form direct bonding to bone after alkali and heat treatments. Biomaterials 22, 2525–2533 (2001)
Aparicio, C., Padros, A., Gil, F.J.: In vivo evaluation of micro-rough and bioactive titanium dental implants using histometry and pull-out tests. J. Mech. Behav. Biomed. Mater. 4, 1672–1682 (2011)
Aparicio, C., Manero, J.M., Conde, F., et al.: Acceleration of apatite nucleation on microrough bioactive titanium for bone-replacing implants. J Biomed Mater Res A 82A, 521–529 (2007)
Aparicio, C., Gil, F.J., Planell, J.A., et al.: Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applications. J. Mater. Sci. Mater. M 13, 1105–1111 (2002)
Albelda, S.M., Buck, C.A.: Integrins and other cell-adhesion molecules. Faseb J. 4, 2868–2880 (1990)
Ratner, B.D.: New ideas in biomaterials science—a path to engineered biomaterials. J. Biomed. Mater. Res. 27, 837–850 (1993)
Massia, S.P., Hubbell, J.A.: An rgd spacing of 440 nm is sufficient for integrin alpha-V-beta-3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation. J. Cell Biol. 114, 1089–1100 (1991)
García, A.J.: Surface modification of biomaterials. In: Atala, A., Lanza, R., Thomson, J.A., Nerem, R. (eds.) Principles of Regenerative Medicine (2nd edn), pp. 663–673. Elsevier/Academic Press, San Diego (2011)
Hall, J., Sorensen, R.G., Wozney, J.M., et al.: Bone formation at rhBMP-2-coated titanium implants in the rat ectopic model. J. Clin. Periodontol. 34, 444–451 (2007)
Bekos, E.J., Ranieri, J.P., Aebischer, P., et al.: Structural-changes of bovine serum-albumin upon adsorption to modified fluoropolymer substrates used for neural cell attachment studies. Langmuir 11, 984–989 (1995)
Tebbe, D., Thull, R., Gbureck, U.: Influence of spacer length on heparin coupling efficiency and fibrinogen adsorption of modified titanium surfaces. Biomed. Eng. Online. 6(1), 31 (2007)
Nadkarni, V.D., Pervin, A., Linhardt, R.J.: Directional immobilization of heparin onto beaded supports. Anal. Biochem. 222, 59–67 (1994)
Nanci, A., Wuest, J.D., Peru, L., et al.: Chemical modification of titanium surfaces for covalent attachment of biological molecules. J. Biomed. Mater. Res. 40, 324–335 (1998)
Puleo, D.A., Kissling, R.A., Sheu, M.S.: A technique to immobilize bioactive proteins, including bone morphogenetic protein-4 (BMP-4), on titanium alloy. Biomaterials 23, 2079–2087 (2002)
Rezania, A., Johnson, R., Lefkow, A.R., et al.: Bioactivation of metal oxide surfaces. 1. Surface characterization and cell response. Langmuir 15, 6931–6939 (1999)
Endo, M., Takagaki, K., Nakamura, T.: A new avenue of proteoglycan studies—of glycosaminoglycan chains using endo-type glycosidases. Seikagaku 67, 1269–1282 (1995)
Puleo, D.A.: Activity of enzyme immobilized on silanized Co-Cr-Mo. J. Biomed. Mater. Res. 29, 951–957 (1995)
Puleo, D.A.: Retention of enzymatic activity immobilized on silanized Co-Cr-Mo and Ti-6Al-4 V. J. Biomed. Mater. Res. 37, 222–228 (1997)
Li, Y., Aparicio, C., Rodriguez-Cabello, C., et al.: Bio-mineralization of nanorough titanium covalently-coated with statherin-derived recombinant biopolymers. J. Dent. Res. (Spec. Iss. B). 89, 3574 (2010)
Schuler, M., Trentin, D., Textor, M., et al.: Biomedical interfaces: Titanium surface technology for implants and cell carriers. Nanomedicine (Lond) 1, 449–463 (2006)
Porte-Durrieu, M.C., Guillemot, F., Pallu, S., et al.: Cyclo-(DfKRG) peptide grafting onto Ti-6Al-4 V: Physical characterization and interest towards human osteoprogenitor cells adhesion. Biomaterials 25, 4837–4846 (2004)
Puleo, D.A.: Biochemical surface modification of Co-Cr-Mo. Biomaterials 17, 217–222 (1996)
Xiao, S.J., Textor, M., Spencer, N.D., et al.: Immobilization of the cell-adhesive peptide Arg-Gly-Asp-Cys (RGDC) on titanium surfaces by covalent chemical attachment. J. Mater. Sci. Mater. Med. 8, 867–872 (1997)
Zhang, F., Xu, F.J., Kang, E.T., et al.: Modification of titanium via surface-initiated atom transfer radical polymerization (ATRP). Ind. Eng. Chem. Res. 45, 3067–3073 (2006)
Kamigaito, M., Ando, T., Sawamoto, M.: Metal-catalyzed living radical polymerization. Chem. Rev. 101, 3689–3745 (2001)
Matyjaszewski, K., Miller, P.J., Shukla, N., et al.: Polymers at interfaces: Using atom transfer radical polymerization in the controlled growth of homopolymers and block copolymers from silicon surfaces in the absence of untethered sacrificial initiator. Macromolecules 32, 8716–8724 (1999)
Matyjaszewski, K., Xia, J.H.: Atom transfer radical polymerization. Chem. Rev. 101, 2921–2990 (2001)
Zhang, F., Shi, Z.L., Chua, P.H., et al.: Functionalization of titanium surfaces via controlled living radical polymerization: From antibacterial surface to surface for osteoblast adhesion. Ind. Eng. Chem. Res. 46, 9077–9086 (2007)
Mrksich, M., Chen, C.S., Xia, Y.N., et al.: Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold. Proc. Natl. Acad. Sci. USA 93, 10775–10778 (1996)
Gawalt, E.S., Avaltroni, M.J., Koch, N., et al.: Self-assembly and bonding of alkanephosphonic acids on the native oxide surface of titanium. Langmuir 17, 5736–5738 (2001)
Danahy, M.P., Avaltroni, M.J., Midwood, K.S., et al.: Self-assembled monolayers of alpha, omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. Langmuir 20, 5333–5337 (2004)
Hayakawa, T., Yoshinari, M., Nagai, M., et al.: X-ray photoelectron spectroscopic studies of the reactivity of basic terminal OH of titanium towards tresyl chloride and fibronectin. Biomed. Res. Tokyo 24, 223–230 (2003)
Huang, N.P., Michel, R., Voros, J., et al.: Poly (l-lysine)-g-poly(ethylene glycol) layers on metal oxide surfaces: Surface-analytical characterization and resistance to serum and fibrinogen adsorption. Langmuir 17, 489–498 (2001)
Kenausis, G.L., Voros, J., Elbert, D.L., et al.: Poly (l-lysine)-g-poly (ethylene glycol) layers on metal oxide surfaces: Attachment mechanism and effects of polymer architecture on resistance to protein adsorption. J. Phys. Chem. B 104, 3298–3309 (2000)
Tosatti, S., De Paul, S.M., Askendal, A., et al.: Peptide functionalized poly (l-lysine)-g-poly (ethylene glycol) on titanium: resistance to protein adsorption in full heparinized human blood plasma. Biomaterials 24, 4949–4958 (2003)
Vandevondele, S., Voros, J., Hubbell, J.A.: RGD-Grafted poly-l-lysine-graft-(polyethylene glycol) copolymers block non-specific protein adsorption while promoting cell adhesion. Biotechnol. Bioeng. 82, 784–790 (2003)
Beutner, R., Michael, J., Forster, A., et al.: Immobilization of oligonucleotides on titanium based materials by partial incorporation in anodic oxide layers. Biomaterials 30, 2774–2781 (2009)
Michael, J., Beutner, R., Hempel, U., et al.: Surface modification of titanium-based alloys with bioactive molecules using electrochemically fixed nucleic acids. J. Biomed. Mater Res. B 80B, 146–155 (2007)
Schliephake, H., Botel, C., Forster, A., et al.: Effect of oligonucleotide mediated immobilization of bone morphogenic proteins on titanium surfaces. Biomaterials 33, 1315–1322 (2012)
De Jonge, L.T., Leeuwenburgh, S.C.G., Wolke, J.G.C., et al.: Organic-inorganic surface modifications for titanium implant surfaces. Pharm. Res. Dordr 25, 2357–2369 (2008)
Bierbaum, S., Hempel, U., Geissler, U., et al.: Modification of Ti6Al4 V surfaces using collagen I, III, and fibronectin. II. Influence on osteoblast responses. J Biomed Mater Res A 67A, 431–438 (2003)
Ku, Y., Chung, C.P., Jang, J.H.: The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior. Biomaterials 26, 5153–5157 (2005)
Steele, J.G., Johnson, G., Mcfarland, C., et al.: Roles of serum vitronectin and fibronectin in initial attachment of human vein endothelial-cells and dermal fibroblasts on oxygen-containing and nitrogen-containing surfaces made by radiofrequency plasmas. J. Biomat. Sci. Polym. E 6, 511–532 (1994)
Carson, A.E., Barker, T.H.: Emerging concepts in engineering extracellular matrix variants for directing cell phenotype. Regen. Med. 4, 593–600 (2009)
Pierschbacher, M.D., Ruoslahti, E.: Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309, 30–33 (1984)
Ruoslahti, E.: RGD and other recognition sequences for integrins. Annu. Rev. Cell Dev. Biol. 12, 697–715 (1996)
Collier, J.H., Segura, T.: Evolving the use of peptides as components of biomaterials. Biomaterials 32, 4198–4204 (2011)
Coin, I., Beyermann, M., Bienert, M.: Solid-phase peptide synthesis: From standard procedures to the synthesis of difficult sequences. Nat. Protoc. 2, 3247–3256 (2007)
Cooper, L.F., Deporter, D., Wennerberg, A., et al.: What physical and/or biochemical characteristics of roughened endosseous implant surfaces particularly enhance their bone-implant contact capability? Int. J. Oral Max. Impl. 20, 307–312 (2005)
Lebaron, R.G., Athanasiou, K.A.: Extracellular matrix cell adhesion peptides: Functional applications in orthopedic materials. Tissue Eng. 6, 85–103 (2000)
Itoh, D., Yoneda, S., Kuroda, S., et al.: Enhancement of osteogenesis on hydroxyapatite surface coated with synthetic peptide (EEEEEEEPRGDT) in vitro. J. Biomed. Mater. Res. 62, 292–298 (2002)
Grzesik, W.J., Robey, P.G.: Bone-matrix rgd glycoproteins—immunolocalization and interaction with human primary osteoblastic bone-cells in-vitro. J. Bone Miner. Res. 9, 487–496 (1994)
Pierschbacher, M.D., Hayman, E.G., Ruoslahti, E.: Cell attachment to fibronectin and the extracellular-matrix. In. Vitro Cell Dev. B 20, 255–265 (1984)
Rezania, A., Thomas, C.H., Branger, A.B., et al.: The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone sialoprotein. J. Biomed. Mater. Res. 37, 9–19 (1997)
Petrie, T.A., Raynor, J.E., Reyes, C.D., et al.: The effect of integrin-specific bioactive coatings on tissue healing and implant osseointegration. Biomaterials 29, 2849–2857 (2008)
Aucoin, L., Griffith, C.M., Pleizier, G., et al.: Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations. J. Biomat. Sci. Polym. E 13, 447–462 (2002)
Benoit, D.S.W., Anseth, K.S.: The effect on osteoblast function of colocalized RGD and PHSRN epitopes on PEG surfaces. Biomaterials 26, 5209–5220 (2005)
Feng, Y.Z., Mrksich, M.: The synergy peptide PHSRN and the adhesion peptide RGD mediate cell adhesion through a common mechanism. Biochemistry-Us 43, 15811–15821 (2004)
Kao, W.J., Lee, D., Schense, J.C., et al.: Fibronectin modulates macrophage adhesion and FBGC formation: The pole of RGD, PHSRN, and PRRARV domains. J. Biomed. Mater. Res. 55, 79–88 (2001)
Kokkoli, E., Ochsenhirt, S.E., Tirrell, M.: Collective and single-molecule interactions of alpha (5) beta (1) integrins. Langmuir 20, 2397–2404 (2004)
Mardilovich, A., Kokkoli, E.: Biomimetic peptide-amphiphiles for functional biomaterials: The role of GRGDSP and PHSRN. Biomacromolecules 5, 950–957 (2004)
Ochsenhirt, S.E., Kokkoli, E., Mccarthy, J.B., et al.: Effect of RGD secondary structure and the synergy site PHSRN on cell adhesion, spreading and specific integrin engagement. Biomaterials 27, 3863–3874 (2006)
Collier, J.H., Rudra, J.S., Gasiorowski, J.Z., et al.: Multi-component extracellular matrices based on peptide self-assembly. Chem. Soc. Rev. 39, 3413–3424 (2010)
Vogel, V.: Mechanotransduction involving multimodular proteins: Converting force into biochemical signals. Annu. Rev. Bioph. Biom. 35, 459–488 (2006)
Reyes, C.D., Garcia, A.J.: Engineering integrin-specific surfaces with a triple-helical collagen-mimetic peptide. J. Biomed. Mater. Res. A 65A, 511–523 (2003)
Bagno, A., Piovan, A., Dettin, M., et al.: Human osteoblast-like cell adhesion on titanium substrates covalently functionalized with synthetic peptides. Bone 40, 693–699 (2007)
Benesch, J., Mano, J.F., Reis, R.L.: Proteins and their peptide motifs in acellular apatite mineralization of scaffolds for tissue engineering. Tissue Eng. Part B-Rev. 14, 433–445 (2008)
Weiner, S., Traub, W.: Organization of hydroxyapatite crystals within collagen fibrils. FEBS Lett. 206, 262–266 (1986)
He, G., Ramachandran, A., Dahl, T., et al.: Phosphorylation of phosphophoryn is crucial for its function as a mediator of biomineralization. J. Biol. Chem. 280, 33109–33114 (2005)
Steitz, S.A., Speer, M.Y., Mckee, M.D., et al.: Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am. J. Pathol. 161, 2035–2046 (2002)
Wada, T., Mckee, M.D., Steitz, S., et al.: Calcification of vascular smooth muscle cell cultures inhibition by osteopontin. Circ. Res. 84, 166–178 (1999)
Ohta, K., Monma, H., Tanaka, J., et al.: Interaction between hydroxyapatite and proteins by liquid chromatography using simulated body fluids as eluents. J. Mater Sci. Mater. Med. 13, 633–637 (2002)
Raj, P.A., Johnsson, M., Levine, M.J., et al.: Salivary statherin—dependence on sequence, charge, hydrogen-bonding potency, and helical conformation for adsorption to hydroxyapatite and inhibition of mineralization. J. Biol. Chem. 267, 5968–5976 (1992)
Wikiel, K., Burke, E.M., Perich, J.W., et al.: Hydroxyapatite mineralization and demineralization in the presence of synthetic phosphorylated pentapeptides. Arch. Oral Biol. 39, 715–721 (1994)
Hunter, G.K., Hauschka, P.V., Poole, A.R., et al.: Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. Biochem. J. 317, 59–64 (1996)
Yao, K.L., Todescan, R., Sodek, J.: Temporal changes in matrix protein-synthesis and messenger-rna expression during mineralized tissue formation by adult-rat bone-marrow cells in culture. J. Bone Miner. Res. 9, 231–240 (1994)
Fujisawa, R., Wada, Y., Nodasaka, Y., et al.: Acidic amino acid-rich sequences as binding sites of osteonectin to hydroxyapatite crystals. Bba. Protein Struct. Mol. 1292, 53–60 (1996)
Stubbs, J.T., Mintz, K.P., Eanes, E.D., et al.: Characterization of native and recombinant bone sialoprotein: Delineation of the mineral-binding and cell adhesion domains and structural analysis of the RGD domain. J. Bone Miner. Res. 12, 1210–1222 (1997)
Norowski, P.A., Bumgardner, J.D.: Biomaterial and antibiotic strategies for peri-implantitis. J. Biomed. Mater. Res. B 88B, 530–543 (2009)
Huang, H.L., Chang, Y.Y., Lai, M.C., et al.: Antibacterial TaN-Ag coatings on titanium dental implants. Surf. Coat. Tech. 205, 1636–1641 (2010)
Zhao, L.Z., Chu, P.K., Zhang, Y.M., et al.: Antibacterial coatings on titanium implants. J. Biomed. Mater. Res. B 91B, 470–480 (2009)
Popat, K.C., Eltgroth, M., Latempa, T.J., et al.: Decreased staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded Titania nanotubes. Biomaterials 28, 4880–4888 (2007)
Lucke, M., Schmidmaier, G., Sadoni, S., et al.: Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats. Bone 32, 521–531 (2003)
Jahoda, D., Nyc, O., Pokorny, D., et al.: Antibiotic treatment for prevention of infectious complications in joint replacement. Acta Chir. Orthopaedicae Et Traumatologiae Cechoslovaca 73, 108–114 (2006)
Alt, V., Bitschnau, A., Osterling, J., et al.: The effects of combined gentamicin-hydroxyapatite coating for cementless joint prostheses on the reduction of infection rates in a rabbit infection prophylaxis model. Biomaterials 27, 4627–4634 (2006)
Radin, S., Campbell, J.T., Ducheyne, P., et al.: Calcium phosphate ceramic coatings as carriers of vancomycin. Biomaterials 18, 777–782 (1997)
Yamamura, K., Iwata, H., Yotsuyanagi, T.: Synthesis of antibiotic-loaded hydroxyapatite beads and invitro drug release testing. J. Biomed. Mater. Res. 26, 1053–1064 (1992)
Kim, W.H., Lee, S.B., Oh, K.T., et al.: The release behavior of CHX from polymer-coated titanium surfaces. Surf. Interface Anal. 40, 202–204 (2008)
Chen, W., Liu, Y., Courtney, H.S., et al.: In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating. Biomaterials 27, 5512–5517 (2006)
Harris, L.G., Tosatti, S., Wieland, M., et al.: Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptide-functionalized poly (l-lysine)-grafted-poly(ethylene glycol) copolymers. Biomaterials 25, 4135–4148 (2004)
Chua, P.H., Neoh, K.G., Kang, E.T., et al.: Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion. Biomaterials 29, 1412–1421 (2008)
Antoci, V., Adams, C.S., Hickok, N.J., et al.: Vancomycin bound to Ti rods reduces periprosthetic infection—preliminary study. Clin. Orthop. Relat. Res. 461, 88–95 (2007)
Antoci, V., Adams, C.S., Parvizi, J., et al.: Covalently attached vancomycin provides a nanoscale antibacterial surface. Clin. Orthop. Relat. Res. 461, 81–87 (2007)
Antoci Jr, V., Adams, C.S., Parvizi, J., et al.: The inhibition of staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection. Biomaterials 29, 4684–4690 (2008)
Antoci, V., King, S.B., Jose, B., et al.: Vancomycin covalently bonded to titanium alloy prevents bacterial colonization. J. Orthop. Res. 25, 858–866 (2007)
Weber, F.A., Lautenbach, E.E.G.: Revision of infected total hip-arthroplasty. Clin. Orthop. Relat. R. 211, 108–115
Tunney, M.M., Ramage, G., Patrick, S., et al.: Antimicrobial susceptibility of bacteria isolated from orthopedic implants following revision hip surgery. Antimicrob. Agents Ch. 42, 3002–3005 (1998)
Antoci, V., Adams, C.S., Hickok, N.J., et al.: Antibiotics for local delivery systems cause skeletal cell toxicity in vitro. Clin. Orthop. Relat. Res. 462, 200–206 (2007)
Ince, A., Schutze, N., Hendrich, C., et al.: Effect of polyhexanide and gentamycin on human osteoblasts and endothelial cells. Swiss Med.Wkly. 137, 139–145 (2007)
Ince, A., Schutze, N., Hendrich, C., et al.: In vitro investigation of orthopedic titanium-coated and brushite-coated surfaces using human osteoblasts in the presence of gentamycin. J. Arthroplasty 23, 762–771 (2008)
Naal, F.D., Salzmann, G.M., Von Knoch, F., et al.: The effects of clindamycin on human osteoblasts in vitro. Arch. Orthop. Trauma Surg. 128, 317–323 (2008)
Salzmann, G.M., Naal, F.D., Von Knoch, F., et al.: Effects of cefuroxime on human osteoblasts in vitro. J. Biomed. Mater. Res. A 82, 462–468 (2007)
Gorr, S.U., Abdolhosseini, M.: Antimicrobial peptides and periodontal disease. J. Clin. Periodontol. 38, 126–141 (2011)
Krisanaprakornkit, S., Khongkhunthian, S.: The role of antimicrobial peptides in periodontal disease. Public Health 21st C. 73–103 (2010)
Hancock, R.E.W., Sahl, H.G.: Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat. Biotechnol. 24, 1551–1557 (2006)
Lau, Y.E., Rozek, A., Scott, M.G., et al.: Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells. Infect. Immun. 73, 583–591 (2005)
Sandgren, S., Wittrup, A., Cheng, F., et al.: The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis. J. Biol. Chem. 279, 17951–17956 (2004)
Kazemzadeh-Narbat, M., Kindrachuk, J., Duan, K., et al.: Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections. Biomaterials 31, 9519–9526 (2010)
Campoccia, D., Montanaro, L., Speziale, P., et al.: Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use. Biomaterials 31, 6363–6377 (2010)
Walsh, C.: Molecular mechanisms that confer antibacterial drug resistance. Nature 406, 775–781 (2000)
Gao, G.Z., Lange, D., Hilpert, K., et al.: The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides. Biomaterials 32, 3899–3909 (2011)
Holmberg, K.V., Hegde, R., Abdolhosseini, M., et al.: Antimicrobial-peptide biofunctionalized titanium for dental implants. J. Dent. Res. 90, 1722 (2011)
Jelokhani-Niaraki, M., Prenner, E.J., Kay, C.M., et al.: Conformation and interaction of the cyclic cationic antimicrobial peptides in lipid bilayers. J. Pept. Res. 60, 23–36 (2002)
Wieczorek, M., Jenssen, H., Kindrachuk, J., et al.: Structural studies of a peptide with immune modulating and direct antimicrobial activity. Chem. Biol. 17, 970–980 (2010)
Bromberg, L.E., Buxton, D.K., Friden, P.M.: Novel periodontal drug delivery system for treatment of periodontitis. J. Controlled Release 71, 251–259 (2001)
Owen, G.R., Jackson, J.K., Chehroudi, B., et al.: An in vitro study of plasticized poly (lactic-co-glycolic acid) films as possible guided tissue regeneration membranes: Material properties and drug release kinetics. J. Biomed. Mater. Res A 95A, 857–869 (2010)
Srirangarajan, S., Mundargi, R.C., Ravindra, S., et al.: Randomized, controlled, single-masked, clinical study to compare and evaluate the efficacy of microspheres and gel in periodontal pocket therapy. J. Periodontol. 82, 114–121 (2011)
Nagase, H., Fields, G.B.: Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides. Biopolymers 40, 399–416 (1996)
Patterson, J., Hubbell, J.A.: Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials 31, 7836–7845 (2010)
Patterson, J., Hubbell, J.A.: SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels. Biomaterials 32, 1301–1310 (2011)
Tokatlian, T., Shrum, C.T., Kadoya, W.M., et al.: Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2-and 3-dimensions. Biomaterials 31, 8072–8080 (2010)
Aulisa, L., Dong, H., Hartgerink, J.D.: Self-assembly of multidomain peptides: Sequence variation allows control over cross-linking and viscoelasticity. Biomacromolecules 10, 2694–2698 (2009)
Tauro Jr, L.B., Ss, Lateef, Ra, Gemeinhart: Matrix metalloprotease selective peptide substrates cleavage within hydrogel matrices for cancer chemotherapy activation. Peptides 29, 1965–1973 (2008)
Galler, K.M., Aulisa, L., Regan, K.R., D’souza, R.N., Hartgerink, J.D.: Self-assembling multidomain peptide hydrogels: designed susceptibility to enzymatic cleavage allows enhanced cell migration and spreading. J. Am. Chem. Soc. 132, 1965–1973 (1973)
Chau, Y., Luo, Y., Cheung, A.C.Y., et al.: Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides—a model for biofunctional scaffolds. Biomaterials 29, 1713–1719 (2008)
Lai, Y.X., Xie, C., Zhang, Z., et al.: Design and synthesis of a potent peptide containing both specific and non-specific cell-adhesion motifs. Biomaterials 31, 4809–4817 (2010)
Gristina, A.G.: Biomaterial-centered infection—microbial adhesion versus tissue integration. Science 237, 1588–1595 (1987)
Neoh, K.G., Hu, X., Zheng, D., et al.: Balancing osteoblast functions and bacterial adhesion on functionalized titanium surfaces. Biomaterials 33, 2813–2822 (2012)
Hetrick, E.M., Schoenfisch, M.H.: Reducing implant-related infections: active release strategies. Chem. Soc. Rev. 35, 780–789 (2006)
Shi, Z., Neoh, K.G., Kang, E.T., et al.: Titanium with surface-grafted dextran and immobilized bone morphogenetic protein-2 for inhibition of bacterial adhesion and enhancement of osteoblast functions. Tissue Eng. Part A 15, 417–426 (2009)
Kim, J., Kim, I.S., Cho, T.H., et al.: Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials 28, 1830–1837 (2007)
Holland, N.B., Qiu, Y.X., Ruegsegger, M., et al.: Biomimetic engineering of non-adhesive glycocalyx-like surfaces using oligosaccharide surfactant polymers. Nature 392, 799–801 (1998)
Vacheethasanee, K., Marchant, R.E.: Surfactant polymers designed to suppress bacterial (staphylococcus epidermidis) adhesion on biomaterials. J. Biomed. Mater. Res. 50, 302–312 (2000)
Maddikeri, R.R., Tosatti, S., Schuler, M., et al.: Reduced medical infection related bacterial strains adhesion on bioactive RGD modified titanium surfaces: A first step toward cell selective surfaces. J. Biomed. Mater. Res. A 84A, 425–435 (2008)
Garcia, A.J., Reyes, C.D.: Bio-adhesive surfaces to promote osteoblast differentiation and bone formation. J. Dent. Res. 84, 407–413 (2005)
Groll, J., Fiedler, J., Engelhard, E., et al.: A novel star PEG-derived surface coating for specific cell adhesion. J. Biomed. Mater. Res. Part A 74A, 607–617 (2005)
Chen, X., Sevilla, P., Aparicio, C.: Surface biofunctionalization by covalent co-immobilization of oligopeptides. Colloids Surf. B. 107, 189–197 (2013)
Geissler, U., Hempel, U., Wolf, C., et al.: Collagen type I-coating of Ti6Al4 V promotes adhesion of osteoblasts. J. Biomed. Mater. Res. 51, 752–760 (2000)
Roehlecke, C., Witt, M., Kasper, M., et al.: Synergistic effect of titanium alloy and collagen type I on cell adhesion, proliferation and differentiation of osteoblast-like cells. Cells Tissues Organs 168, 178–187 (2001)
Morra, M., Cassinelli, C., Cascardo, G., et al.: Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies. Biomaterials 24, 4639–4654 (2003)
Morra, M., Cassinelli, C., Cascardo, G., et al.: Collagen I-coated titanium surfaces: Mesenchymal cell adhesion and in vivo evaluation in trabecular bone implants. J. Biomed. Mater. Res. A 78A, 449–458 (2006)
Muller, R., Abke, J., Schnell, E., et al.: Surface engineering of stainless steel materials by covalent collagen immobilization to improve implant biocompatibility. Biomaterials 26, 6962–6972 (2005)
Muller, R., Abke, J., Schnell, E., et al.: Influence of surface pretreatment of titanium- and cobalt-based biomaterials on covalent immobilization of fibrillar collagen. Biomaterials 27, 4059–4068 (2006)
Couchourel, D., Escoffier, C., Rohanizadeh, R., et al.: Effects of fibronectin on hydroxyapatite formation. J. Inorg. Biochem. 73, 129–136 (1999)
Garcia, A.J., Ducheyne, P., Boettiger, D.: Effect of surface reaction stage on fibronectin-mediated adhesion of osteoblast-like cells to bioactive glass. J. Biomed. Mater. Res. 40, 48–56 (1998)
Pegueroles, M., Aguirre, A., Engel, E., et al.: Effect of blasting treatment and Fn coating on MG63 adhesion and differentiation on titanium: a gene expression study using real-time RT-PCR. J. Mater. Sci. Mater. Med. 22, 617–627 (2011)
El-Ghannam, A., Starr, L., Jones, J.: Laminin-5 coating enhances epithelial cell attachment, spreading, and hemidesmosome assembly on Ti-6Al-4 V implant material in vitro. J. Biomed. Mater. Res. 41, 30–40 (1998)
Werner, S., Huck, O., Frisch, B., et al.: The effect of microstructured surfaces and laminin-derived peptide coatings on soft tissue interactions with titanium dental implants. Biomaterials 30, 2291–2301 (2009)
Werner, S., Kocgozlu, L., Huck, O., et al.: Epithelial cell adhesion on a new laminin-5 functionalized porous titanium material. Int. J. Artif. Organs 31, 639–649 (2008)
Lange, K., Herold, M., Scheideler, L., et al.: Investigation of initial pellicle formation on modified titanium dioxide (TiO2) surfaces by reflectometric interference spectroscopy (RIfS) in a model system. Dent. Mater. 20, 814–822 (2004)
Rezania, A., Healy, K.E.: Biomimetic peptide surfaces that regulate adhesion, spreading, cytoskeletal organization, and mineralization of the matrix deposited by osteoblast-like cells. Biotechnol. Prog. 15, 19–32 (1999)
Lynch, S.E., Buser, D., Hernandez, R.A., et al.: Effects of the platelet-derived growth-factor insulin-like growth factor-i combination on bone regeneration around titanium dental implants—results of a pilot-study in beagle dogs. J. Periodontol. 62, 710–716 (1991)
Ito, Y., Chen, G.P., Imanishi, Y.: Micropatterned immobilization of epidermal growth factor to regulate cell function. Bioconjug. Chem. 9, 277–282 (1998)
Kuhl, P.R., Griffithcima, L.G.: Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase. Nat. Med. 2, 1022–1027 (1996)
Jensen, E.D., Gopalakrishnan, R., Westendorf, J.J.: Bone morphogenic protein 2 activates protein kinase d to regulate histone deacetylase 7 localization and repression of runx2. J. Biol. Chem. 284, 2225–2234 (2009)
Yamaguchi, A., Komori, T., Suda, T.: Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr. Rev. 21, 393–411 (2000)
Suzawa, M., Takeuchi, Y., Fukumoto, S., et al.: Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro. Endocrinology 140, 2125–2133 (1999)
Fiorellini, J.P., Buser, D., Riley, E., et al.: Effect on bone healing of bone morphogenetic protein placed in combination with endosseous implants: A pilot study in beagle dogs. Int. J. Periodont. Rest. 21, 41–47 (2001)
Marukawa, E., Asahina, I., Oda, M., et al.: Functional reconstruction of the non-human primate mandible using recombinant human bone morphogenetic protein-2. Int. J. Oral Max. Surg. 31, 287–295 (2002)
Seol, Y.J., Park, Y.J., Lee, S.C., et al.: Enhanced osteogenic promotion around dental implants with synthetic binding motif mimicking bone morphogenetic protein (BMP)-2. J. Biomed. Mater. Res. A 77A, 599–607 (2006)
Leong, L.M., Brickell, P.M.: Bone morphogenetic protein-4. Int. J. Biochem. Cell B 28, 1293–1296 (1996)
Morra, M.: Biochemical modification of titanium surfaces: Peptides and ECM proteins. Eur. Cells Mater. 12, 1–15 (2006)
Schmidmaier, G., Wildemann, B., Ostapowicz, D., et al.: Long-term effects of local growth factor (IGF-I and TGF-beta 1) treatment on fracture healing—a safety study for using growth factors. J. Orthop. Res. 22, 514–519 (2004)
Ruoslahti, E.: Proteoglycans in cell regulation. J. Biol. Chem. 264, 13369–13372 (1989)
Rammelt, S., Illert, T., Bierbaum, S., et al.: Coating of titanium implants with collagen, RGD peptide and chondroitin sulfate. Biomaterials 27, 5561–5571 (2006)
Zou, X.N., Li, H.S., Chen, L., et al.: Stimulation of porcine bone marrow stromal cells by hyaluronan, dexamethasone and rhBMP-2. Biomaterials 25, 5375–5385 (2004)
Chen, W.Y.J., Abatangelo, G.: Functions of hyaluronan in wound repair. Wound Repair Regen 7, 79–89 (1999)
Morra, M., Cassinelli, C., Cascardo, G., et al.: Covalently-linked hyaluronan promotes bone formation around Ti implants in a rabbit model. J. Orthop. Res. 27, 657–663 (2009)
Fisher, L.W., Fedarko, N.S.: Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect. Tissue Res. 44, 33–40 (2003)
Young, M.F.: Bone matrix proteins: Their function, regulation, and relationship to osteoporosis. Osteoporos. Int. 14, S35–S42 (2003)
Yoshitake, H., Rittling, S.R., Denhardt, D.T., et al.: Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. P. Natl. Acad. Sci. USA 96, 8156–8160 (1999)
Asou, Y., Rittling, S.R., Yoshitake, H., et al.: Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone. Endocrinology 142, 1325–1332 (2001)
Boskey, A., Spevak, L., Tan, M., et al.: Dentin sialoprotein (DSP) has limited effects on in vitro apatite formation and growth. Calcif. Tissue Int. 67, 472–478 (2000)
Hunter, G.K., Goldberg, H.A.: Nucleation of hydroxyapatite by bone sialoprotein. Proc. Natl. Acad. Sci. USA 90, 8562–8565 (1993)
Fisher, L.W., Torchia, D.A., Fohr, B., et al.: Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin. Biochem. Bioph. Res. Co. 280, 460–465 (2001)
Tye, C.E., Rattray, K.R., Warner, K.J., et al.: Delineation of the hydroxyapatite-nucleating domains of bone sialoprotein. J. Biol. Chem. 278, 7949–7955 (2003)
Fujisawa, R., Kuboki, Y.: Affinity of bone sialoprotein and several other bone and dentin acidic proteins to collagen fibrils. Calcif. Tissue Int. 51, 438–442 (1992)
Tye, C.E., Hunter, G.K., Goldberg, H.A.: Identification of the type I collagen-binding domain of bone sialoprotein and characterization of the mechanism of interaction. J. Biol. Chem. 280, 13487–13492 (2005)
Karadag, A., Ogbureke, K.U.E., Fedarko, N.S., et al.: Bone sialoprotein, matrix metalloproteinase 2, and alpha (v) beta (3) integrin in osteotropic cancer cell invasion. J. Natl. Cancer Inst. 96, 956–965 (2004)
Goldberg, H.A., Warner, K.J., Li, M.C., et al.: Binding of bone sialoprotein, osteopontin and synthetic polypeptides to hydroxyapatite. Connect. Tissue Res. 42, 25–37 (2001)
Byzova, T.V., Kim, W., Midura, R.J., et al.: Activation of integrin alpha (V) beta (3) regulates cell adhesion and migration to bone sialoprotein. Exp. Cell Res. 254, 299–308 (2000)
Grzesik, W.J., Robey, P.G.: Bone matrix RGD glycoproteins: immunolocalization and interaction with human primary osteoblastic bone cells in vitro. J. Bone Miner. Res. 9, 487–496 (1994)
Chen, J., Shapiro, H.S., Sodek, J.: Development expression of bone sialoprotein mRNA in rat mineralized connective tissues. J. Bone Miner. Res. 7, 987–997 (1992)
Cooper, L.F., Yliheikkila, P.K., Felton, D.A., et al.: Spatiotemporal assessment of fetal bovine osteoblast culture differentiation indicates a role for BSP in promoting differentiation. J. Bone Miner. Res. 13, 620–632 (1998)
Gordon, J.A., Tye, C.E., Sampaio, A.V., et al.: Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro. Bone 41, 462–473 (2007)
Luo, G., Ducy, P., Mckee, M.D., et al.: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386, 78–81 (1997)
Beertsen, W., Vandenbos, T., Niehof, J.: Mineralization of dentinal collagen sheets complexed with alkaline-phosphatase and integration with newly formed bone following subperiosteal implantation over osseous defects in rat calvaria. Bone Miner. 20, 41–55 (1993)
Bellows, C.G., Aubin, J.E., Heersche, J.N.M.: Initiation and progression of mineralization of bone nodules formed invitro—the role of alkaline-phosphatase and organic phosphate. Bone Miner. 14, 27–40 (1991)
Termine, J.D., Kleinman, H.K., Whitson, S.W., et al.: Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26, 99–105 (1981)
Delany, A.M., Amling, M., Priemel, M., et al.: Osteopenia and decreased bone formation in osteonectin-deficient mice. J. Clin. Invest. 105, 1325–1325, 915 (2000)
Brogden, K.A.: Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 3, 238–250 (2005)
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Chen, X., Li, Y., Aparicio, C. (2013). Biofunctional Coatings for Dental Implants. In: Nazarpour, S. (eds) Thin Films and Coatings in Biology. Biological and Medical Physics, Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2592-8_4
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