Abstract
The use of track structure calculations in radiotherapy using conventional low-LET radiation sources is discussed. Microdosimetry and emergent nanodosimetry methods are considered in explaining variations in quality factors associated with clinical practice and in vitro data. Transformation rate in the human derived for the in vitro system CGL1 is presented as a model for the induction of secondary cancer, a late effect associated with radiotherapy treatment.
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References
B.J. Mijnheer, J.J. Battermann, A. Wambersie, Radiotherapy and Oncology, 8, 237–252 (1987)
C. Lindborg, J.-E. Grindborg, Radiat. Prot. Dosim. 70, 541–6 (1997)
W. Friedland, P. Jacob, H.G. Paretzke, M. Merzagora, A. Ottolenghi, Radiat. Environ. Biophys. 38 39–47 (1999)
H. Nikjoo, P. ONeill, W.E. Wilson, D.T. Goodhead, Radiat. Res. 156 577–83 (2001)
Y. Hsiao, R.D. Stewart, Phys. Med. Biol. 53, 233–244 (2008)
A.M. Kellerer, H.H. Rossi, Radiat. Res. 75, 471–488 (1978)
M. Zaider, Med. Phys. 25, 791–792 (1998)
R.K. Sachs, D.J. Brenner, Med. Phys. 25, 2071–2073 (1998)
M. Zaider, Med. Phys. 25, 2074–5 (1998)
D.J. Brenner, M. Zaider, Med. Phys. 25, 1055–1057 (1998)
P. Pihet, H.G. Menzel, Med. Phys. 26, 848–852 (1999)
D.J. Brenner, C.-S. Leu, J.F. Beatty, R.E. Shefer, Phys. Med. Biol. 44, 323–333 (1999)
M. Zaider, L. Hanin, Med. Phys. 38, 574–583 (2011)
F. Verhaegen, I.A. Castellano, Radiat. Prot. Dosim. 99, 393–6 (2002)
B. Reniers, F. Verhaegen, Radiat. Prot. Dosim. 122, 401–3 (2007)
H.H. Liu, F. Verhaegen, Radiat. Prot. Dosim. 99, 425–7 (2002)
D.J. Carlson, R.D. Stewart, X.A. Li, K. Jennings, J.Z. Wang, M. Guerrero, Phys. Med. Biol. 49, 4477–4491 (2004)
R.D. Stewart, X.A. Li, Med. Phys. 34, 3739–3751 (2007)
D.J. Brenner, Semin. Radiat. Oncol. 18, 234-239 (2008)
J.P. Kirkpatrick, J.J. Meyer, L.B. Marks, Semin. Radiat. Oncol. 18, 240-243 (2008)
H.T.Jr. Peterson, J. Radiol. Prot. 30, 801–811 (2010)
G.J. Heyes, A.J. Mill, M.W. Charles, J. Radiol. Prot. 29, A123–A132 (2009)
N. Hunter, C.R. Muirhead, J. Radiol. Prot. 29, 5–21 (2009)
J.E. Pattison, L.C. Payne, R.P. Hugtenburg, A.H. Beddoe, M.W. Charles, Radiat. Prot. Dosim. 109, 175–180 (2004)
J.E. Pattison, R.P. Hugtenburg, A.H. Beddoe, M.W. Charles, Radiat. Prot. Dosim. 95, 125–135 (2001)
L. Walsh, W. Rühm, A.M. Kellerer, Radiat. Environ. Biophys. 43, 145–151 (2004)
D. Harder, N. Petoussi-Henß, D. Regulla, M. Zankl, G. Dietze, Radiat. Prot. Dosim. 109, 291–295 (2004)
A.M. Kellerer, H. Roos, Radiat. Prot. Dosim. 113, 245–250 (2005)
R.D. Stewart, W.E. Wilson, J.C. McDonald, D.J. Strom, Phys. Med. Biol. 47, 79–88 (2002)
C.S. Liu, C.-J. Tung, Y.H. Hu, C.M. Chou, T.C. Chao, C.C. Lee, Nucl. Instrum. Meths. B. 267, 1823–9 (2009)
T.C. Chao, Y.S. Huang, F.Y. Hsu, Y. Hsiao, C.C. Lee, C.J. Tung, Radiat. Prot. Dosim. 143, 248–252 (2011)
R.P. Hugtenburg, Z. Chaoui, J.E. Pattison, Nucl Instrum. Meths. A 580, 157–160 (2007)
R.P. Hugtenburg, Eu. J. Radiol. 68, S126–8 (2008)
R.P. Hugtenburg, A.E.R. Baker, S. Green, Appl. Radiat. Isotop. 67, 433–5 (2009)
R.P. Hugtenburg, A.E.R. Baker, S. Green, Appl. Radiat. Isotop. 67, S168-170 (2009)
M. Zaider, D.J. Brenner, Radiat. Res. 103, 302–316 (1985)
ICRU: Report 40. The quality factor in radiation protection. International Commission of Radiation Units and Measurements, Bethesda, MA, (1986)
R.J. Cannell, D.E. Watt, Phys. Med. Biol. 30, 255-258 (1985)
A.V. Lappa, E.A. Bigildeev, D.S. Burmistrov, O.N. Vasilyev, Radiat. Environ. Biophys. 32, 1–19 (1993)
E.A. Bigildeev, V. Michalik, Radiat. Phys. Chem. 47, 197–207 (1996)
W. Friedland, M. Dingfelder, P. Jacob, H.G. Paretzke, Radiat. Phys. Chem. 72, 279–86 (2005)
H.H. Rossi, M. Zaider, Microdosimetry and its applications, Springer-Verlag, Berlin (1996)
A. Mozumder, Y. Hatano, (Eds.), Charged Particle and Photon Interactions with Matter. Chemical, Physicochemical and Biological Consequences with Applications, Marcel Dekker, New York, (2004)
G. Garty, S. Shchemelinin, A. Breskin, R. Chechik, G. Assaf, I. Orion, V. Bashkirov, R. Schulte, B. Grosswendt, B.: Nucl. Instrum. Meth. A, 492 212–235 (2002)
M.N. Cornforth, K.M. Greulich-Bode, B.D. Loucas, J. Arsuaga, M. Vázquez, Sachs, M. Brückner, M. Molls, P. Hahnfeldt, L. Hlatky, D.J. Brenner, J. Cell Biol. 159 237-244
H.H. Rossi, Radiation Protection Dosimetry 52, 9–12 (1994)
Acknowledgements
Frank Verhaegen is acknowledged for providing his thesis and the basic data on lineal energy spectra therein. Geoff Heyes, Alan Beddoe and Ihsan Al Affan are thanked for their helpful discussion.
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Hugtenburg, R.P. (2012). Track-Structure Monte Carlo Modelling in X-ray and Megavoltage Photon Radiotherapy. In: GarcÃa Gómez-Tejedor, G., Fuss, M. (eds) Radiation Damage in Biomolecular Systems. Biological and Medical Physics, Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2564-5_18
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