Abstract
Cardiovascular (CV) system changes are known to occur in childhood as part of the “silent” evidence of the beginning of adult heart diseases. Although autopsy studies have shown atherosclerotic accumulation of lipids and plaques in arteries of children and adolescents related to risk factors, it is now possible to study CV changes in the general population of youth. Noninvasive techniques have been developed to access underlying damage of the CV renal system. Ultrasonography measurement of carotid intima-media thickness has become an established tool for evaluating subclinical atherosclerosis in adults and is now being applied to study children, especially with hypercholesterolemia, diabetes and obesity. Other techniques are being used to study compliance and distensibility of the vascular tree, related to arterial wall stiffness resulting from hypertension and other etiologies of adult heart diseases. Noninvasive studies of the CV system are providing an excellent background to understand early changes leading to CV events in adulthood and a basis for beginning Preventive Cardiology at an early age.
Keywords
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Kochanek KD, Smith BL (2004) Deaths: preliminary data for 2002. Natl Vital Stat Rep 52:1–47
Rosamond WD, Chambless LE, Folsom AR, Cooper LS, Conwill DE, Clegg L, Wang CH, Heiss G (1998) Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994. N Engl J Med 339:861–867
Berenson GS, Srinivasan S, Boa W, Newman WP III, Tracy RP, Wattigney WA (1998) Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 338:1650–1656
A Preliminary report from the Pathological Determinants of Atherosclerosis in Youth (PDAY) Research Group (1990) A relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. J Am Med Assoc 264:3018–3024
Tracy RE, Newman WP III, Wattigney WA, Srinivasan SR, Strong JP, Berenson GS (1995) Histologic features of atherosclerosis and hypertension from autopsies of young individuals in a defined geographic population: the Bogalusa Heart Study. Atherosclerosis 116:163–179
Grewal J, Chan S, Frohlich J, Mancini GB (2003) Assessment of novel risk factors in patients at low risk for cardiovascular events based on Framingham risk stratification. Clin Invest Med (Medecine Clinique et Experimentale) 26:158–165
Greenland P, Abrams J, Aurigemma GP, Bond MG, Clark LT, Criqui MH, Crouse JR III, Friedman L, Fuster V, Herrington DM, Kuller LH, Ridker PM, Roberts WC, Stanford W, Stone N, Swan HJ, Taubert KA, Wexler L (2000) Prevention conference V: beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. Circulation 101:E16–E22
Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, Clegg LX (1997) Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 146:483–494
Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH, Azen SP (1998) The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 128:262–269
O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22
Salonen JT, Salonen R (1991) Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb 11:1245–1249
Simons PC, Algra A, Bots ML, Grobbee DE, van der Graaf Y (1999) Common carotid intima-media thickness and arterial stiffness: indicators of cardiovascular risk in high-risk patients. The SMART Study (Second Manifestations of ARTerial disease). Circulation 100:951–957
Dijk J, van der Graaf Y, Bots M, Grobbee D, Algra A (2006) Carotid intima-media thickness and the risk of new vascular events in patients with manifest atherosclerotic disease: the SMART study. Eur Heart J 27:1971–1978
Grobbee D, Bots M (1994) Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med 236:567–573
Urbina EM, Srinivasan SR, Tang R, Bond MG, Kieltyka L, Berenson GS (2002) Impact of multiple coronary risk factors on the intima-media thickness of different segments of carotid artery in healthy young adults (The Bogalusa Heart Study). Am J Cardiol 90:953–958
Selvin E, Coresh J, Golden SH, Boland LL, Brancati FL, Steffes MW (2005) Glycemic control, atherosclerosis, and risk factors for cardiovascular disease in individuals with diabetes: the atherosclerosis risk in communities study. Diabetes Care 28:1965–1973
Bots ML, Dijk JM, Oren A, Grobbee DE (2002) Carotid intima-media thickness, arterial stiffness and risk of cardiovascular disease: current evidence. J Hypertens 20:2317–2325
Furberg CD, Adams HP Jr, Applegate WB, Byington RP, Espeland MA, Hartwell T, Hunninghake DB, Lefkowitz DS, Probstfield J, Riley WA, et al (1994) Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. Circulation 90:1679–1687
Pitt B, Byington RP, Furberg CD, Hunninghake DB, Mancini GB, Miller ME, Riley W (2000) Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. PREVENT Investigators. Circulation 102:1503–1510
Salonen R, Nyyssonen K, Porkkala E, Rummukainen J, Belder R, Park JS, Salonen JT (1995) Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries. Circulation 92:1758–1764
Smilde TJ, van Wissen S, Wollersheim H, Trip MD, Kastelein JJ, Stalenhoef AF (2001) Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 357:577–581
Terpstra WF, May JF, Smit AJ, Graeff PA, Meyboom-de Jong B, Crijns HJ (2004) Effects of amlodipine and lisinopril on intima-media thickness in previously untreated, elderly hypertensive patients (the ELVERA trial). J Hypertens 22:1309–1316
Zanchetti A, Bond MG, Hennig M, Neiss A, Mancia G, Dal Palu C, Hansson L, Magnani B, Rahn KH, Reid JL, Rodicio J, Safar M, Eckes L, Rizzini P (2002) Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial. Circulation 106:2422–2427
Bots ML, Evans GW, Riley WA, Grobbee DE (2003) Carotid intima-media thickness measurements in intervention studies: design options, progression rates, and sample size considerations: a point of view. Stroke 34:2985–2994
Davis PH, Dawson JD, Riley WA, Lauer RM (2001) Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: the Muscatine Study. Circulation 104:2815–2819
Freedman DS, Dietz WH, Tang R, Mensah GA, Bond MG, Urbina EM, Srinivasan S, Berenson GS (2004) The relation of obesity throughout life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 28:159–166
Li S, Chen W, Srinivasan SR, Bond MG, Tang R, Urbina EM, Berenson GS (2003) Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA 290:2271–2276
Oren A, Vos L, Uiterwaal C, Gorissen W, Grobbee D, Bots M (2003) Change in body mass index from adolescence to young adulthood and increased carotid intima-media thickness at 28 years of age: the atherosclerosis risk in young adults study. Int J Obes Relat Metab Disord 27:1383–1390
Raitakari OT, Juonala M, Kahonen M, Taittonen L, Laitinen T, Maki-Torkko N, Jarvisalo MJ, Uhari M, Jokinen E, Ronnemaa T, Akerblom HK, Viikari JS (2003) Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the cardiovascular risk in Young Finns Study. JAMA 290:2277–2283
Aggoun Y, Bonnet D, Sidi D, Girardet JP, Brucker E, Polak M, Safar ME, Levy BI (2000) Arterial mechanical changes in children with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 20:2070–2075
Jarvisalo MJ, Jartti L, Nanto-Salonen K, Irjala K, Ronnemaa T, Hartiala JJ, Celermajer DS, Raitakari OT (2001) Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children. Circulation 104:2943–2947
Koeijvoets KC, Rodenburg J, Hutten BA, Wiegman A, Kastelein JJ, Sijbrands EJ (2005) Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia: substudy of an intima-media thickness trial. Circulation 112:3168–3173
Tonstad S, Joakimsen O, Stensland-Bugge E, Leren TP, Ose L, Russell D, Bonaa KH (1996) Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects. Arterioscler Thromb Vasc Biol 16:984–991
Wiegman A, de Groot E, Hutten BA, Rodenburg J, Gort J, Bakker HD, Sijbrands EJ, Kastelein JJ (2004) Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. Lancet 363:369–370
Lande MB, Carson NL, Roy J, Meagher CC (2006) Effects of childhood primary hypertension on carotid intima media thickness: a matched controlled study. Hypertension 48:40–44
Sorof JM, Alexandrov AV, Cardwell G, Portman RJ (2003) Carotid artery intimal-medial thickness and left ventricular hypertrophy in children with elevated blood pressure. Pediatrics 111:61–66
Meyer AA, Kundt G, Steiner M, Schuff-Werner P, Kienast W (2006) Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. Pediatrics 117:1560–1567
Woo KS, Chook P, Yu CW, Sung RY, Qiao M, Leung SS, Lam CW, Metreweli C, Celermajer DS (2004) Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening. Int J Obes Relat Metab Disord 28:852–857
Iannuzzi A, Licenziati MR, Acampora C, Salvatore V, Auriemma L, Romano ML, Panico S, Rubba P, Trevisan M (2004) Increased carotid intima-media thickness and stiffness in obese children. Diabetes Care 27:2506–2508
Singh TP, Groehn H, Kazmers A (2003) Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus. J Am Coll Cardiol 41:661–665
Iannuzzi A, Licenziati MR, Acampora C, Renis M, Agrusta M, Romano L, Valerio G, Panico S, Trevisan M (2006) Carotid artery stiffness in obese children with the metabolic syndrome. Am J Cardiol 97:528–531
Sass C, Herbeth B, Chapet O, Siest G, Visvikis S, Zannad F (1998) Intima-media thickness and diameter of carotid and femoral arteries in children, adolescents and adults from the Stanislas cohort: effect of age, sex, anthropometry and blood pressure. J Hypertens 16:1593–1602
Ishizu T, Ishimitsu T, Yanagi H, Seo Y, Obara K, Moriyama N, Watanabe S, Yamaguchi I (2004) Effect of age on carotid arterial intima-media thickness in childhood. Heart Vessels 19:189–195
Espeland MA, Tang R, Terry JG, Davis DH, Mercuri M, Crouse JR III (1999) Associations of risk factors with segment-specific intimal-medial thickness of the extracranial carotid artery. Stroke 30:1047–1055
Jourdan C, Wuhl E, Litwin M, Fahr K, Trelewicz J, Jobs K, Schenk JP, Grenda R, Mehls O, Troger J, Schaefer F (2005) Normative values for intima-media thickness and distensibility of large arteries in healthy adolescents. J Hypertens 23:1707–1715
Urbina EM, Kimball TR, McCoy CE, Khoury PR, Daniels SR, Dolan LM (2009) Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation 119:2913–2919
Koklu E, Kurtoglu S, Akcakus M, Yikilmaz A, Coskun A, Gunes T (2007) Intima-media thickness of the abdominal aorta of neonate with different gestational ages. J Clin Ultrasound 35:491–497
Skilton MR, Evans N, Griffiths KA, Harmer JA, Celermajer DS (2005) Aortic wall thickness in newborns with intrauterine growth restriction. Lancet 365:1484–1486
Gunes T, Koklu E, Yikilmaz A, Ozturk MA, Akcakus M, Kurtoglu S, Coskun A, Koklu S (2007) Influence of maternal smoking on neonatal aortic intima-media thickness, serum IGF-I and IGFBP-3 levels. Eur J Pediatr 166:1039–1044
Volanen I, Jarvisalo MJ, Vainionpaa R, Arffman M, Kallio K, Angle S, Ronnemaa T, Viikari J, Marniemi J, Raitakari OT, Simell O (2006) Increased aortic intima-media thickness in 11-year-old healthy children with persistent Chlamydia pneumoniae seropositivity. Arterioscler Thromb Vasc Biol 26:649–655
Volanen I, Kallio K, Saarinen M, Jarvisalo MJ, Vainionpaa R, Ronnemaa T, Viikari J, Marniemi J, Simell O, Raitakari OT (2008) Arterial intima-media thickness in 13-year-old adolescents and previous antichlamydial antimicrobial use: a retrospective follow-up study. Pediatrics 122:e675–e681
Dawson JD, Sonka M, Blecha MB, Lin W, Davis PH (2009) Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study. J Am Coll Cardiol 53:2273–2279
Roman MJ, Saba PS, Pini R, Spitzer M, Pickering TG, Rosen S, Alderman MH, Devereux RB (1992) Parallel cardiac and vascular adaptation in hypertension. Circulation 86:1909–1918
Liang YL, Teede H, Kotsopoulos D, Shiel L, Cameron JD, Dart AM, McGrath BP (1998) Non-invasive measurements of arterial structure and function: repeatability, interrelationships and trial sample size. Clin Sci (Lond) 95:669–679
Wendelhag I, Wiklund O, Wikstrand J (1992) Arterial wall thickness in familial hypercholesterolemia. Ultrasound measurement of intima-media thickness in the common carotid artery. Arterioscler Thromb 12:70–77
Wendelhag I, Wiklund O, Wikstrand J (1995) Intima-media thickness after cholesterol lowering in familial hypercholesterolemia. A three-year ultrasound study of common carotid and femoral arteries. Atherosclerosis 117:225–236
Roman MJ, Pickering TG, Schwartz JE, Pini R, Devereux RB (1995) Association of carotid atherosclerosis and left ventricular hypertrophy. J Am Coll Cardiol 25:83–90
Riley W, Freedman D, Higgs N, Barnes R, Zinkgraf S, Berenson G (1992) Decreased arterial elasticity associated with cardiovascular disease risk factors in the young. The Bogalusa Heart Study. Arteriosclerosis 6:378–386
Cavallini M, Roman M, Blank S, Pini R, Pickering T, Devereux R (1996) Association of the auscultatory gap with vascular disease in hypertensive patients. Ann Intern Med 124:877–883
Salomaa V, Riley W, Kark JD, Nardo C, Folsom AR (1995) Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation 91:1432–1443
Urbina EM, Srinivasan, SR, Kieltyka RL, Tang R, Bond MG, Chen W, Berenson GS (2004) Correlates of carotid artery stiffness in young adults: the Bogalusa Heart Study. Atherosclerosis 176:157–164
Urbina EM, Williams RV, Alpert BS, Collins RT, Daniels SR, Hayman L, Jacobson M, Mahoney L, Mietus-Snyder M, Rocchini A, Steinberger J, McCrindle B (2009) on behalf of the American Heart Association Atherosclerosis H, Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young. Noninvasive assessment of subclinical atherosclerosis in children and adolescents. Recommendations for standard assessment for clinical research. A Scientific Statement from the American Heart Association. Hypertension. HYPERTENSIONAHA.109.192639
Woo KS, Chook P, Yu CW, Sung RY, Qiao M, Leung SS, Lam CW, Metreweli C, Celermajer DS (2004) Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation 109:1981–1986
Wiegman A, Hutten BA, de Groot E, Rodenburg J, Bakker HD, Buller HR, Sijbrands EJ, Kastelein JJ (2004) Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial. J Am Med Assoc 292:331–337
Crouse JR III, Raichlen JS, Riley WA, Evans GW, Palmer MK, O’Leary DH, Grobbee DE, Bots ML (2007) Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial. J Am Med Assoc 297:1344–1353
Anderson HC (1983) Calcific diseases. Arch Path Lab Med 107:341–348
Stary HC (1989) Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis 9(Suppl I):I-19–I-32
Epstein FH, Simpson R, Boas EP (1957) The epidemiology of atherosclerosis among a random sample of clothing workers of different ethnic origins in New York City. II. Associations between serum lipid levels, blood pressure, overweight, and some other variables. J Chron Dis 5:329–341
Margolis JR, Chen JTT, Kong Y, Peter RH, Behar VS, Kisslo JA (1980) The diagnostic and prognostic significance of coronary artery calcification. Radiology 137:609–616
Wang L, Jerosch-Herold M, Jacobs DR Jr, Shahar E, Detrano R, Folsom AR (2006) Coronary artery calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 48:1018–1026
Mahoney LT, Burns TL, Stanford W, Thompson BH, Witt JD, Rost CA, Lauer RM (1996) Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study. J Am Coll Cardiol 27:277–284
Janowitz WR, Agatston AS, Kaplan G, Viamonte M Jr (1993) Differences in prevalence and extent of coronary artery calcium detected by ultrafast computed tomography in asymptomatic men and women. Am J Cardiol 72:247–254
Sakuma H, Takeda K, Hirano T, Okuda Y, Matsumura K, Yamaguchi N, Nakana T, Takano M (1988) Plain chest radiograph with computed tomography; improved sensitivity for the detection of coronary artery calcification. Am J Roentgen 151:27–30
Bormann J, Stanford W, Stenberg R, Winniford M, Galvin J, Berbaum K, Talman C (1992) Ultrafast CT detection of coronary artery stenosis. Am J Cardiac Imaging 6:191–196
Hamby RI, Tabrah F, Wisoff BG, Hartstein ML (1974) Coronary artery calcification: clinical implications and angiographic correlates. Am Heart J 87:565–570
Wong ND, Kouwabunpat D, Vo A, Detrano RC, Eisenberg H, Goel M, Tobis JM (1994) Coronary calcium and atherosclerosis by ultrafast computed tomography in asymptomatic men and women: relation to age and risk factors. Am Heart J 127:422–430
Wong ND, Vo A, Abrahamson D, Tobis JM, Eisenberg H, Detrano RC (1994) Detection of coronary artery calcium by ultrafast computed tomography and its relation to clinical evidence of coronary artery disease. Am J Cardiol 73:223–227
Goel M, Wong ND, Eisenberg H, Hagar J, Kelly D, Tobis JM (1992) Risk factor correlates of coronary calcium as evaluated by ultrafast computed tomography. Am J Cardiol 70:977–980
Loecker TH, Schwartz RS, Cotta CW, Hickman JR Jr (1992) Fluoroscopic coronary artery calcification and associated coronary disease in asymptomatic young men. J Am Coll Cardiol 19:1167–1172
Michos ED, Nasir K, Braunstein JB, Rumberger JA, Budoff MJ, Post WS, Blumenthal RS (2006) Framingham risk equation underestimates subclinical atherosclerosis risk in asymptomatic women. Atherosclerosis 184:201–206
Dabelea D, Kinney G, Snell-Bergeon JK, Hokanson JE, Eckel RH, Ehrlich J, Garg S, Hamman RF, Rewers M (2003) Effect of Type 1 diabetes on the gender difference in coronary artery calcification: a role for Insulin resistance?: the Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. Diabetes 52:2833–2839
Gidding SS, Bookstein LC, Chomka EV (1998) Usefulness of electron beam tomography in adolescents and young adults with heterozygous familial hypercholesterolemia. Circulation 98:2580–2583
Kaichi S, Tsuda E, Fujita H, Kurosaki K, Tanaka R, Naito H, Echigo S (2008) Acute coronary artery dilation due to Kawasaki disease and subsequent late calcification as detected by electron beam computed tomography. Pediatr Cardiol 29:568–573
Frey EE, Matherne CP, Mahoney LT, Sato Y, Stanford W, Smith WL (1988) Coronary artery aneurysms due to Kawasaki disease: diagnosis with ultrafast CT. Radiology 167:725–726
Dadlani GH, Gingell RL, Orie JD, Roland JM, Najdzionek J, Lipsitz SR, Pieroni DR, Lipshultz SE (2005) Coronary artery calcifications in the long-term follow-up of Kawasaki disease. Am Heart J 150:1016
Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, Sider D, Wang Y, Chung J, Emerick A, Greaser L, Elashoff RM, Salusky IB (2000) Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342:1478–1483
Sheth RD, Perez MD, goldstein SL (2003) Cardiovascular calcifications in pediatric patients receiving maintenance dialysis. Pediatr Nephrol 18:810–813
Ishitani MB, Milliner DS, Kim DY, Bohorquez HE, Heimbach JK, Sheedy PF II, Morgenstern BZ, Gloor JM, Murphy JG, McBane RD, Bielak LF, Peyser PA, Stegall MD (2005) Early subclinical coronary artery calcification in young adults who were pediatric kidney transplant recipients. Am J Transplant 5:1689–1693
Bae KT, Hong C, Takahashi N, Gutierrez F, Sharkey AM, Hirsch R, Canter CE, Bae KT, Hong C, Takahashi N, Gutierrez F, Sharkey AM, Hirsch R, Canter CE (2004) Multi-detector row computed tomographic angiography in pediatric heart transplant recipients: initial observations. Transplantation 77:599–602
Starkman HS, Cable G, Hala V, Hecht H, Donnelly CM, Starkman HS, Cable G, Hala V, Hecht H, Donnelly CM (2003) Delineation of prevalence and risk factors for early coronary artery disease by electron beam computed tomography in young adults with type 1 diabetes. Diabetes Care 26:433–436
O’Rourke MF, Staessen JA, Vlachopoulos C, Duprez D, Plante GE (2002) Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertens 15:426–444
Laurent S, Hayoz D, Trazzi S, Boutouyrie P, Waeber B, Omboni S, Brunner HR, Mancia G, Safar M (1993) Isobaric compliance of the radial artery is increased in patients with essential hypertension. J Hypertens 11:89–98
Mangoni AA, Mircoli L, Giannattasio C, Ferrari AU, Mancia G (1996) Heart rate-dependence of arterial distensibility in vivo. J Hypertens 14:897–901
Safar ME, London BM (1994) The arterial system in human hypertension. Blackwell Scientific, London
Bank AJ, Kaiser DR, Rajala S, Cheng A (1999) In vivo human brachial artery elastic mechanics: effects of smooth muscle relaxation. Circulation 100:41–47
Bank AJ, Wang H, Holte JE, Mullen K, Shammas R, Kubo SH (1996) Contribution of collagen, elastin, and smooth muscle to in vivo human brachial artery wall stress and elastic modulus. Circulation 94:3263–3270
Lopez-Beltran EA, Blackshear PL, Finkelstein SM, Cohn JN (1998) Non-invasive studies of peripheral vascular compliance using a non-occluding photoplethysmographic method. Med Biol Eng Comput 36:748–753
Giannattasio C, Mangoni AA, Failla M, Stella ML, Carugo S, Bombelli M, Sega R, Mancia G (1997) Combined effects of hypertension and hypercholesterolemia on radial artery function. Hypertension 29:583–586
Hopkins KD, Lehmann ED, Jones RL, Turay RC, Gosling RG (1996) A family history of NIDDM is associated with decreased aortic distensibility in normal healthy young adult subjects. Diabetes Care 19:501–503
Urbina EM, Brinton TJ, Elkasabany A, Berenson GS (2002) Brachial artery distensibility and relation to cardiovascular risk factors in healthy young adults (The Bogalusa Heart Study). Am J Cardiol 89:946–951
Urbina EM, Kieltkya L, Tsai J, Srinivasan SR, Berenson GS (2005) Impact of multiple cardiovascular risk factors on brachial artery distensibility in young adults: the Bogalusa Heart Study. Am J Hypertens 18:767–771
Liao D, Arnett DK, Tyroler HA, Riley WA, Chambless LE, Szklo M, Heiss G (1999) Arterial stiffness and the development of hypertension. The ARIC study. Hypertension 34:201–206
Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG (2002) Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 106:2085–2090
Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, Benetos A (2001) Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37:1236–1241
Blacher J, Asmar R, Diane S, London GM, Safar ME (1999) Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 33:1111–1117
Syeda B, Gottsauner-Wolf M, Denk S, Pichler P, Khorsand A, Glogar D (2003) Arterial compliance: a diagnostic marker for atherosclerotic plaque burden? Am J Hypertens 16:356–362
Bhuiyan AR, Li S, Li H, Chen W, Srinivasan SR, Berenson GS (2005) Distribution and correlates of arterial compliance measures in asymptomatic young adults: the Bogalusa Heart Study. Am J Hypertens 18:684–691
Li H, Srinivasan SR, Chen W, Xu JH, Li S, Berenson GS (2005) Vascular abnormalities in asymptomatic, healthy young adult smokers without other major cardiovascular risk factors: the Bogalusa Heart Study. Am J Hypertens 18:319–324
Li H, Srinivasan SR, Berenson GS (2006) Comparison of the measures of pulsatile arterial function between asymptomatic younger adult smokers and former smokers: the Bogalusa Heart Study. Am J Hypertens 19:897–901
Arnett DK, Glasser SP, McVeigh G, Prineas R, Finklestein S, Donahue R, Cohn JN, Sinaiko A (2001) Blood pressure and arterial compliance in young adults: the Minnesota Children’s Blood Pressure Study. Am J Hypertens 14:200–205
Covic A, Haydar AA, Bhamra-Ariza P, Gusbeth-Tatomir P, Goldsmith DJ (2005) Aortic pulse wave velocity and arterial wave reflections predict the extent and severity of coronary artery disease in chronic kidney disease patients. J Nephrol 18:388–396
Jelic S, Bartels MN, Mateika JH, Ngai P, DeMeersman RE, Basner RC (2002) Arterial stiffness increases during obstructive sleep apneas. Sleep 25:850–855
London GM, Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME (2001) Arterial wave reflections and survival in end-stage renal failure. Hypertension 38:434–438
Wilkinson IB, Prasad K, Hall IR, Thomas A, MacCallum H, Webb DJ, Frenneaux MP, Cockcroft JR (2002) Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol 39:1005–1011
Wilkinson IB, MacCallum H, Rooijmans DF, Murray GD, Cockcroft JR, McKnight JA, Webb DJ (2000) Increased augmentation index and systolic stress in type 1 diabetes mellitus. QJM 93:441–448
Tomiyama H, Arai T, Koji Y, Yambe M, Motobe K, Zaydun G, Yamamoto Y, Hori S, Yamashina A (2004) The age-related increase in arterial stiffness is augmented in phases according to the severity of hypertension. Hypertens Res-Clin Exp 27:465–470
Schnabel R, Larson MG, Dupuis J, Lunetta KL, Lipinska I, Meigs JB, Yin X, Rong J, Vita JA, Newton-Cheh C, Levy D, Keaney JF Jr, Vasan RS, Mitchell GF, Benjamin EJ (2008) Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension 51:1651–1657
Kohara K, Tabara Y, Oshiumi A, Miyawaki Y, Kobayashi T, Miki T (2005) Radial augmentation index: a useful and easily obtainable parameter for vascular aging. Am J Hypertens 18:11S–14S
Matsui Y, Ishikawa J, Eguchi K, Hoshide S, Miyashita H, Shimada K, Kario K, Matsui Y, Ishikawa J, Eguchi K, Hoshide S, Miyashita H, Shimada K, Kario K (2008) The influence of wave reflection on left ventricular hypertrophy in hypertensive patients is modified by age and gender. Hypertens Res-Clin Exp 31:649–656
Olafiranye O, Qureshi G, Salciccioli L, Weber M, Lazar J (2008) Association of beta-blockers use with increased aortic wave reflection. J Am Soc Hypertens 2:64–69
de Luca N, Mallion JM, O’Rourke MF, O’Brien E, Rahn KH, Trimarco B, Romero R, De Leeuw PW, Hitzenberger G, Battegay E, Duprez D, Sever P, Safar ME (2004) Regression of left ventricular mass in hypertensive patients treated with perindopril/indapamide as a first-line combination: the REASON echocardiography study. Am J Hypertens 17:660–667
Papamichael CM, Karatzi KN, Papaioannou TG, Karatzis EN, Katsichti P, Sideris V, Zakopoulos N, Zampelas A, Lekakis JP (2008) Acute combined effects of olive oil and wine on pressure wave reflections: another beneficial influence of the Mediterranean diet antioxidants? J Hypertens 26:223–229
Lehmann ED, Gosling RG, Sonksen PH (1992) Arterial wall compliance in diabetes. Diabet Med 9:114–119
Nichols WW, O’Rourke MF (1990) McDonald’s blood flow in arteries: theoretical, experimental and clinical principles, 3rd edn. Edward Arnold, London
London GM, Marchais SJ, Safar ME, Genest AF, Guerin AP, Metivier F, Chedid K, London AM (1990) Aortic and large artery compliance in end-stage renal failure. Kidney Int 37:137–142
Lehmann ED, Watts GF, Gosling RG (1992) Aortic distensibility and hypercholesterolaemia. Lancet 340:1171–1172
Avolio AP, Chen SG, Wang RP, Zhang CL, Li MF, O’Rourke MF (1983) Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation 68:50–58
Vaitkevicius PV, Fleg JL, Engel JH, O’Connor FC, Wright JG, Lakatta LE, Yin FC, Lakatta EG (1993) Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation 88:1456–1462
Li S, Chen W, Srinivasan SR, Berenson GS (2005) Influence of metabolic syndrome on arterial stiffness and its age-related change in young adults: the Bogalusa Heart Study. Atherosclerosis 180:349–354
Li S, Chen W, Srinivasan SR, Berenson GS (2004) Childhood blood pressure as a predictor of arterial stiffness in young adults: the bogalusa heart study. Hypertension 43:541–546
Whincup PH, Gilg JA, Donald AE, Katterhorn M, Oliver C, Cook DG, Deanfield JE (2005) Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors. Circulation 112:1789–1797
Leeson CP, Whincup PH, Cook DG, Mullen MJ, Donald AE, Seymour CA, Deanfield JE (2000) Cholesterol and arterial distensibility in the first decade of life: a population-based study. Circulation 101:1533–1538
Singhal A, Farooqi IS, Cole TJ, O’Rahilly S, Fewtrell M, Kattenhorn M, Lucas A, Deanfield J (2002) Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 106:1919–1924
Urbina EM, Bean JA, Daniels SR, D’Alessio D, Dolan, LM (2007) Overweight and hyperinsulinemia provide individual contributions to compromises in brachial artery distensibility in healthy adolescents and young adults: brachial distensibility in children. J Am Soc Hypertens 1:200–207
Urbina EM, Khoury P, Martin LJ, D’Alessio D, Dolan LM (2009) Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults. Int J Obes 33:1118–1125
Haller MJ, Samyn M, Nichols WW, Brusko T, Wasserfall C, Schwartz RF, Atkinson M, Shuster JJ, Pierce GL, Silverstein JH (2004) Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes. Diabetes Care 27:2911–2917
Galler A, Heitmann A, Siekmeyer W, Gelbrich G, Kapellen T, Kratzsch J, Kiess W (2009) Increased arterial stiffness in children and adolescents with type 1 diabetes: no association between arterial stiffness and serum levels of adiponectin. Pediatr Diabetes 11:38–46
Brooks BA, Molyneaux LM, Yue DK (2001) Augmentation of central arterial pressure in Type 2 diabetes. Diabet Med 18:374–380
Covic A, Mardare N, Gusbeth-Tatomir P, Brumaru O, Gavrilovici C, Munteanu M, Prisada O, Goldsmith DJ (2006) Increased arterial stiffness in children on haemodialysis. Nephrol Dial Transplant 21:729–735
Mahmud A, Feely J (2003) Spurious systolic hypertension of youth: fit young men with elastic arteries. Am J Hypertens 16:229–232
Kyvelou S-MG, Vyssoulis GP, Karpanou EA, Adamopoulos DN, Deligeorgis AD, Cokkinos DV, Stefanadis CI (2008) Arterial stiffness in offspring of hypertensive parents: a pilot study. Int J Cardiol 129:438–440
Kucerova J, Filipovsky J, Staessen JA, Cwynar M, Wojciechowska W, Stolarz K, Kuznetsova T, Gasowski J, Dolejsova M, Grodzicki T, Kawecka-Jaszcz K, Fagard R (2006) Arterial characteristics in normotensive offspring of parents with or without a history of hypertension. Am J Hypertens 19:264–269
Stella A, Gessaroli M, Cifiello BI, Salardi S, Reggiani A, Cacciari E, D’Addato M (1984) Elastic modulus in young diabetic patients (ultrasound measurements of pulse wave velocity). Angiology 35:729–734
Woolam GL, Schnur PL, Vallbona C, Hoff HE (1962) The pulse wave velocity as an early indicator of atherosclerosis in diabetic subjects. Circulation 25:533–539
Tedesco MA, Di Salvo G, Ratti G, Natale F, Calabrese E, Grassia C, Iacono A, Lama G (2001) Arterial distensibility and ambulatory blood pressure monitoring in young patients with neurofibromatosis type 1. Am J Hypertens 14:559–566
Tedesco MA, Ratti G, Di Salvo G, Martiniello AR, Limongelli G, Grieco M, Calabrese E, Grassia C, Iacono A, Lama G (2000) Noninvasive evaluation of arterial abnormalities in young patients with neurofibromatosis type 1. Angiology 51:733–741
Kwok KL, Ng DK, Cheung YF (2003) BP and arterial distensibility in children with primary snoring. Chest 123:1561–1566
Cheung YF, Yung TC, Tam SC, Ho MH, Chau AK (2004) Novel and traditional cardiovascular risk factors in children after Kawasaki disease: implications for premature atherosclerosis. J Am Coll Cardiol 43:120–124
Cheung YF, Brogan PA, Pilla CB, Dillon MJ, Redington AN (2002) Arterial distensibility in children and teenagers: normal evolution and the effect of childhood vasculitis. Arch Dis Child 87:348–351
de Divitiis M, Pilla C, Kattenhorn M, Donald A, Zadinello M, Wallace S, Redington A, Deanfield J (2003) Ambulatory blood pressure, left ventricular mass, and conduit artery function late after successful repair of coarctation of the aorta. J Am Coll Cardiol 41:2259–2265
Roegel JC, Heinrich E, De Jong W, Stephan D, Charpentier A, Eisenmann B, Imbs JL (1998) Vascular and neuroendocrine components in altered blood pressure regulation after surgical repair of coarctation of the aorta. J Hum Hypertens 12:517–525
Ou P, Celermajer DS, Raisky O, Jolivet O, Buyens F, Herment A, Sidi D, Bonnet D, Mousseaux E (2008) Angular (Gothic) aortic arch leads to enhanced systolic wave reflection, central aortic stiffness, and increased left ventricular mass late after aortic coarctation repair: evaluation with magnetic resonance flow mapping. J Thorac Cardiovasc Surg 135:62–68
Im JA, Lee JW, Shim JY, Lee HR, Lee DC (2007) Association between brachial-ankle pulse wave velocity and cardiovascular risk factors in healthy adolescents. J Pediatr 150:247–251
Zhu H, Yan W, Ge D, Treiber FA, Harshfield GA, Kapuku G, Snieder H, Dong Y (2007) Cardiovascular characteristics in American youth with prehypertension. Am J Hypertens 20:1051–1057
Ge D, Young TW, Wang X, Kapuku GK, Treiber FA, Snieder H (2007) Heritability of arterial stiffness in black and white American youth and young adults. Am J Hypertens 20:1065–1072
Urbina EM, Kimball TR et al (2010) Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus. J Hypertens 28(8):1692–1698
Avolio AP, Deng FQ, Li WQ, Luo YF, Huang ZD, Xing LF, O’Rourke MF (1985) Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation 71:202–210
Okada M, Yakata M (1989) Normal ranges of pulse wave velocity and the changes with age. Rinsho Byori 37:215–218
McEniery CM, Yasmin, Hall IR, Qasem A, Wilkinson IB, Cockcroft JR (2005) Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol 46:1753–1760
Collins RT, Somes GW, Alpert BS (2008) Differences in arterial compliance among normotensive adolescent groups: Collins arterial compliance in adolescents. Pediatr Cardiol 29:929–934
Niboshi A, Hamaoka K, Sakata K, Inoue F (2006) Characteristics of brachial-ankle pulse wave velocity in Japanese children. Eur J Pediatr 165:625–629
Urbina EM, Dolan LM, McCoy CE, Khoury PR, Daniels SR, Kimball TR (2011) Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults. J Pediatr 158:715–721
Deanfield J, Donald A, Ferri C, Giannattasio C, Halcox J, Halligan S, Lerman A, Mancia G, Oliver JJ, Pessina AC, Rizzoni D, Rossi GP, Salvetti A, Schiffrin EL, Taddei S, Webb DJ (2005) Endothelial function and dysfunction. Part I: methodological issues for assessment in the different vascular beds: a statement by the working group on endothelin and endothelial factors of the European society of hypertension. J Hypertens 23:7–17
Chan SY, Mancini GB, Kuramoto L, Schulzer M, Frohlich J, Ignaszewski A (2003) The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol 42:1037–1043
Li XP, Zhao SP, Zhang XY, Liu L, Gao M, Zhou QC (2000) Protective effect of high density lipoprotein on endothelium-dependent vasodilatation. Int J Cardiol 73:231–236
Felmeden DC, Spencer CG, Blann AD, Beevers DG, Lip GY (2003) Low-density lipoprotein subfractions and cardiovascular risk in hypertension: relationship to endothelial dysfunction and effects of treatment. Hypertension 41:528–533
Balletshofer BM, Rittig K, Stock J, Lehn-Stefan A, Overkamp D, Dietz K, Haring HU (2003) Insulin resistant young subjects at risk of accelerated atherosclerosis exhibit a marked reduction in peripheral endothelial function early in life but not differences in intima-media thickness. Atherosclerosis 171(2):303–309
Lee SJ, Lee DW, Kim KS, Lee IK (2001) Effect of estrogen on endothelial dysfunction in postmenopausal women with diabetes. Diabetes Res Clin Pract 54:S81–S92
Celermajer DS, Adams MR, Clarkson P, Robinson J, McCredie R, Donald A, Deanfield JE (1996) Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med 334(3):150–154
Franzoni F, Ghiadoni L, Galetta F, Plantinga Y, Lubrano V, Huang Y, Salvetti G, Regoli F, Taddei S, Santoro G, Salvetti A (2005) Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men. Am J Hypertens 18(4 Pt 1):510–516
Amar S, Gokce N, Morgan S, Loukideli M, Van Dyke TE, Vita JA (2003) Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler Thromb Vasc Biol 23:1245–1249
Ohike Y, Kozaki K, Iijima K, Eto M, Kojima T, Ohga E, Santa T, Imai K, Hashimoto M, Yoshizumi M, Ouchi Y (2005) Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure—possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine. Circ J 69:221–226
Ip MS, Tse HF, Lam B, Tsang KW, Lam WK (2004) Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 169:348–353
Fuchsjager-Mayrl G, Pleiner J, Wiesinger GF, Sieder AE, Quittan M, Nuhr MJ, Francesconi C, Seit HP, Francesconi M, Schmetterer L, Wolzt M (2002) Exercise training improves vascular endothelial function in patients with type 1 diabetes. Diabetes Care 25:1795–1801
Hamdy O, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, Moussa A, Caselli A, Caballero AE, Economides PA, Veves A, Horton ES (2003) Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care 26:2119–2125
Ryan M, McInerney D, Owens D, Collins P, Johnson A, Tomkin GH (2000) Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity. QJM 93:85–91
Sondergaard E, Moller JE, Egstrup K (2003) Effect of dietary intervention and lipid-lowering treatment on brachial vasoreactivity in patients with ischemic heart disease and hypercholesterolemia. Am Heart J 145:E19
Williams MJ, Sutherland WH, McCormick MP, de Jong SA, McDonald JR, Walker RJ (2001) Vitamin C improves endothelial dysfunction in renal allograft recipients. Nephrol Dial Transplant 16:1251–1255
Agewall S, Wright S, Doughty RN, Whalley GA, Duxbury M, Sharpe N (2000) Does a glass of red wine improve endothelial function? Eur Heart J 21:74–78
Chou EJ, Keevil JG, Aeschlimann S, Wiebe DA, Folts JD, Stein JH (2001) Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. Am J Cardiol 88:553–555
Vlachopoulos C, Aznaouridis K, Alexopoulos N, Economou E, Andreadou I, Stefanadis C (2005) Effect of dark chocolate on arterial function in healthy individuals. Am J Hypertens 18:785–791
Woo KS, Chook P, Lolin YI, Sanderson JE, Metreweli C, Celermajer DS (1999) Folic acid improves arterial endothelial function in adults with hyperhomocystinemia. J Am Coll Cardiol 34:2002–2006
Alonso R, Mata P, De Andres R, Villacastin BP, Martinez-Gonzalez J, Badimon L (2001) Sustained long-term improvement of arterial endothelial function in heterozygous familial hypercholesterolemia patients treated with simvastatin. Atherosclerosis 157:423–429
de Jongh S, Lilien MR, op’t Roodt J, Stroes ES, Bakker HD, Kastelein JJ (2002) Early statin therapy restores endothelial function in children with familial hypercholesterolemia. J Am Coll Cardiol 40:2117–2121
Joyce M, Moore K, Thompson C, Fitzgerald P, Fennessy F, Kelly CJ, Bouchier-Hayes DJ (2004) Hydroxy-methylglutaryl-coenzyme A reductase inhibition improves endothelial dysfunction in type-1 diabetes. Eur J Vasc Endovasc Surg 27:432–437
Beckman JA, Liao JK, Hurley S, Garrett LA, Chui D, Mitra D, Creager MA (2004) Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein. Circ Res 95:217–223
Ghiadoni L, Huang Y, Magagna A, Buralli S, Taddei S, Salvetti A (2001) Effect of acute blood pressure reduction on endothelial function in the brachial artery of patients with essential hypertension. J Hypertens 19:547–551
Anderson TJ, Elstein E, Haber H, Charbonneau F (2000) Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilation in patients with coronary disease (BANFF study). J Am Coll Cardiol 35:60–66
Jensen-Urstad K, Johansson J (2001) Gender difference in age-related changes in vascular function. J Intern Med 250:29–36
Atkov OY, Balahonova TV, Pogorelova OA (1998) Non-invasive ultrasound detection of endothelial dysfunction. Eur J Ultrasound 7:37–45
Tounian P, Aggoun Y, Dubem B, Varille V, Guy-Grand B, Sidi D, Giradet J-P, Bonnet D (2001) Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 358:1400–1404
Bonnet D, Aggoun Y, Szezepanski I, Bellal N, Blanche S (2004) Arterial stiffness and endothelial dysfunction in HIV-infected children. AIDS 18:1037–1041
Kari JA, Donald AE, Vallance DT, Bruckdorfer KR, Leone A, Mullen MJ, Bunce T, Dorado B, Deanfield JE, Rees L (1997) Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney Int 52:468–472
Deng YB, Li TL, Xiang HJ, Chang Q, Li CL (2003) Impaired endothelial function in the brachial artery after Kawasaki disease and the effects of intravenous administration of vitamin C. Pediatr Infect Dis J 22:34–39
Jarvisalo MJ, Lehtimaki T, Raitakari OT (2004) Determinants of arterial nitrate-mediated dilatation in children: role of oxidized low-density lipoprotein, endothelial function, and carotid intima-media thickness. Circulation 109:2885–2889
Charakida M, Donald AE, Green H, Storry C, Clapson M, Caslake M, Dunn DT, Halcox JP, Gibb DM, Klein NJ, Deanfield JE (2005) Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation 112:103–109
Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE (1992). Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340(8828):1111–1115
Jarvisalo MJ, Raitakari M, Toikka JO, Putto-Laurila A, Rontu R, Laine S, Lehtimaki T, Ronnemaa T, Viikari J, Raitakari OT (2004) Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes. Circulation 109:1750–1755
Donaghue KC, Robinson J, McCredie R, Fung A, Silink M, Celermajer DS (1998) Macroangiopathy—does it play a role in young people? Horm Res 1:38–40
Lilien MR, Stroes ES, Op’t Roodt J, de Jongh S, Schroder CH, Koomans HA (2003) Vascular function in children after renal transplantation. Am J Kidney Dis 41:684–691
Jarvisalo MJ, Harmoinen A, Hakanen M, Paakkunainen U, Viikari J, Hartiala J, Lehtimaki T, Simell O, Raitakari OT (2002) Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol 22:1323–1328
Aburawi E, Liuba P, Pesonen E, Yla-Herttuala S, Sjoblad S (2004) Acute respiratory viral infections aggravate arterial endothelial dysfunction in children with type 1 diabetes. Diabetes Care 27:2733–2735
Donaghue KC, Robinson J, McCredie R, Fung A, Silink M, Celermajer DS (1997) Large vessel dysfunction in diabetic adolescents and its relationship to small vessel complications. J Pediatr Endocrinol Metab 10:593–598
de Jongh S, Lilien MR, Bakker HD, Hutten BA, Kastelein JJ, Stroes ES (2002) Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia. Atherosclerosis 163:193–197
Mietus-Snyder M, Malloy MJ (1998) Endothelial dysfunction occurs in children with two genetic hyperlipidemias: improvement with antioxidant vitamin therapy. J Pediatr 133:35–40
Sorensen KE, Celermajer DS, Georgakopoulos D, Hatcher G, Betteridge DJ, Deanfield JE (1994) Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J Clin Invest 93:50–55
Aggoun Y, Farpour-Lambert NJ, Marchand LM, Golay E, Maggio AB, Beghetti M (2008) Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure. Eur Heart J 29:792–799
Woo KS, Chook P, Yu CW, Sung RY, Qiao M, Leung SS, Lam CW, Metreweli C, Celermajer DS (2004) Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening. Int J Obes Relat Metab Disord 28:852–857
Kallio K, Jokinen E, Raitakari OT, Hamalainen M, Siltala M, Volanen I, Kaitosaari T, Viikari J, Ronnemaa T, Simell O (2007) Tobacco smoke exposure is associated with attenuated endothelial function in 11-year-old healthy children. Circulation 115:3205–3212
Leeson CP, Kattenhorn M, Morley R, Lucas A, Deanfield JE (2001) Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life. Circulation 103:1264–1268
Leeson CP, Whincup PH, Cook DG, Donald AE, Papacosta OLA, Deanfield JE (1997) Flow-mediated dilation in 9- to 11-year-old children: the influence of intrauterine and childhood factors. Circulation 96:2223–2238
Slyper AH (2004) Clinical review 168: what vascular ultrasound testing has revealed about pediatric atherogenesis, and a potential clinical role for ultrasound in pediatric risk assessment. J Clin Endocrinol Metab 89:3089–3095
Abbott RA, Harkness MA, Davies PS (2002) Correlation of habitual physical activity levels with flow-mediated dilation of the brachial artery in 5–10 year old children. Atherosclerosis 160:233–239
Kelly AS, Wetzsteon RJ, Kaiser DR, Steinberger J, Bank AJ, Dengel DR (2004) Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise. J Pediatr 145:731–736
Watts K, Beye P, Siafarikas A, O’Driscoll G, Jones TW, Davis EA, Green DJ (2004) Effects of exercise training on vascular function in obese children. J Pediat 144:620–625
Watts K, Beye P, Siafarikas A, Davis EA, Jones TW, O’Driscoll G, Green DJ (2004) Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents. J Am Coll Cardiol 43:1823–1827
Wiltshire EJ, Gent R, Hirte C, Pena A, Thomas DW, Couper JJ (2002) Endothelial dysfunction relates to folate status in children and adolescents with type 1 diabetes. Diabetes 51:2282–2286
Bennett-Richards K, Kattenhorn M, Donald A, Oakley G, Varghese Z, Rees L, Deanfield JE (2002) Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure? Circulation 105:1810–1815
Bennett-Richards KJ, Kattenhorn M, Donald AE, Oakley GR, Varghese Z, Bruckdorfer KR, Deanfield JE, Rees L (2002) Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney Int 62:1372–1378
Engler MM, Engler MB, Malloy MJ, Chiu EY, Schloetter MC, Paul SM, Stuehlinger M, Lin KY, Cooke JP, Morrow JD, Ridker PM, Rifai N, Miller E, Witztum JL, Mietus-Snyder M (2003) Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) trial. Circulation 108:1059–1063
Engler MM, Engler MB, Malloy M, Chiu E, Besio D, Paul S, Stuehlinger M, Morrow J, Ridker P, Rifai N, Mietus-Snyder M (2004) Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY study. Int J Clin Pharmacol Ther 42:672–679
de Jongh S, Vissers MN, Rol P, Bakker HD, Kastelein JJ, Stroes ES (2003) Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia. J Inherit Metab Dis 26:343–351
Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R (2002) International brachial artery reactivity task F guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39:257–265
Aeschlimann SE, Mitchell CK, Korcarz CE (2004) Ultrasound brachial artery reactivity testing: technical considerations. J Am Soc Echocardiogr 17:697–699
Tsai WC, Li YH, Lin CC, Chao TH, Chen JH (2004) Effects of oxidative stress on endothelial function after a high-fat meal. Clin Sci 106:315–319
Etsuda H, Takase B, Uehata A, Kusano H, Hamabe A, Kuhara R, Akima T, Matsushima Y, Arakawa K, Satomura K, Kurita A, Ohsuzu F (1999) Morning attenuation of endothelium-dependent, flow-mediated dilation in healthy young men: possible connection to morning peak of cardiac events? Clinical Cardiology 22:417–421
Gaenzer H, Sturm W, Kirchmair R, Neumayr G, Ritsch A, Patsch J (2000) Circadian variation of endothelium-dependent vasodilatation of the brachial artery as a confounding factor in the evaluation of endothelial function. Atherosclerosis 149:227–228
English JL, Jacobs LO, Green G, Andrews TC (1998) Effect of the menstrual cycle on endothelium-dependent vasodilation of the brachial artery in normal young women. Am J Cardiol 82:256–258
Lambert J, Stehouwer CD (1996) Modulation of endothelium-dependent, flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation 94:2319–2320
Schroeder S, Enderle MD, Baumbach A, Ossen R, Herdeg C, Kuettner A, Karsch KR (2000) Influence of vessel size, age and body mass index on the flow-mediated dilatation (FMD%) of the brachial artery. Int J Cardiol 76:219–225
Silber HA, Ouyang P, Bluemke DA, Gupta SN, Foo TK, Lima JA (2005) Why is flow-mediated dilation dependent on arterial size? Assessment of the shear stimulus using phase-contrast magnetic resonance imaging. Am J Physiol Heart Circ Physiol 288:H822–H828
Jarvisalo MJ, Ronnemaa T, Volanen I, Kaitosaari T, Kallio K, Hartiala JJ, Irjala K, Viikari JS, Simell O, Raitakari OT (2002) Brachial artery dilatation responses in healthy children and adolescents. Am J Physiol Heart Circ Physiol 282:H87–H92
Uehata A, Lieberman EH, Gerhard MD, Anderson TJ, Ganz P, Polak JF, Creager MA, Yeung AC (1997) Noninvasive assessment of endothelium-dependent flow-mediated dilation of the brachial artery. Vasc Med 2:87–92
Accini JL, Sotomayor A, Trujillo F, Barrera JG, Bautista L, Lopez-Jaramillo P (2001) Colombian study to assess the use of noninvasive determination of endothelium-mediated vasodilatation (CANDEV). Normal values and factors associated. Endothelium 8:157–166
Sorensen K, Celermajer D, Spiegelhalter D, Georgakopoulos D, Robinson J, Thomas O, Deanfield J (1995) Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. Br Heart J 74:247–253
Bonetti PO, Barsness GW, Keelan PC, Schnell TI, Pumper GM, Kuvin JT, Schnall RP, Holmes DR, Higano ST, Lerman A (2003) Enhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery disease. J Am Coll Cardiol 41:1761–1768
Kuvin J, Patel A, Sliney K, Pandian N, Sheffy J, Schnall R, Karas R, Udelson J (2003) Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 146:168–174
Hamburg NM, Keyes MJ, Larson MG, Vasan RS, Schnabel R, Pryde MM, Mitchell GF, Sheffy J, Vita JA, Benjamin EJ (2008) Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation 117:2467–2474
O’Brien LM, Holbrook CR, Vanderlaan M, Amiel J, Gozal D (2005) Autonomic function in children with congenital central hypoventilation syndrome and their families. Chest 128:2478–2484
Tauman R, O’Brien LM, Mast BT, Holbrook CR, Gozal D (2004) Peripheral arterial tonometry events and electroencephalographic arousals in children. Sleep 27:502–506
Haller MJ, Stein J, Shuster J, Theriaque D, Silverstein J, Schatz DA, Earing MG, Lerman A, Mahmud FH (2007) Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes. Pediatr Diabetes 8:193–198
Mahmud FH, Van Uum S, Kanji N, Thiessen-Philbrook H, Clarson CL, Mahmud FH, Van Uum S, Kanji N, Thiessen-Philbrook H, Clarson CL (2008) Impaired endothelial function in adolescents with type 1 diabetes mellitus. J Pediatr 152:557–562
Cracowski JL, Minson CT, Salvat-Melis M, Halliwill JR (2006) Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends Pharmacol Sci 27:503–508
Vuilleumier P, Decosterd D, Maillard M, Burnier M, Hayoz D (2002) Postischemic forearm skin reactive hyperemia is related to cardovascular risk factors in a healthy female population. [see comment]. J Hypertens 20:1753–1757
Elhadd TA, Khan F, Kirk G, McLaren M, Newton RW, Greene SA, Belch JJ (1998) Influence of puberty on endothelial dysfunction and oxidative stress in young patients with type 1 diabetes. Diabetes Care 21:1990–1996
Khan F, Elhadd TA, Greene SA, Belch JJ (2000) Impaired skin microvascular function in children, adolescents, and young adults with type 1 diabetes. Diabetes Care 23:215–220
Gozal D, Kheirandish-Gozal L, Serpero LD, Sans Capdevila O, Dayyat E (2007) Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy. Circulation 116:2307–2314
Gaeta G, De Michele M, Cuomo S, Guarini P, Foglia MC, Bond MG, Trevisan M (2000) Arterial abnormalities in the offspring of patients with premature myocardial infarction. N Engl J Med 343:840–846
Singhal A, Cole TJ, Fewtrell M, Deanfield J, Lucas A (2004) Is slower early growth beneficial for long-term cardiovascular health? Circulation 109:1108–1113
Fernandez-Real JM, Castro A, Vazquez G, Casamitjana R, Lopez-Bermejo A, Penarroja G, Ricart W (2004) Adiponectin is associated with vascular function independent of insulin sensitivity. Diabetes Care 27:739–745
Olsen MH, Wachtell K, Hermann KL, Bella JN, Dige-Petersen H, Rokkedal J, Ibsen H (2002) Left ventricular hypertrophy is associated with reduced vasodilatory capacity in the brachial artery in patients with longstanding hypertension. A LIFE substudy. Blood Press 11:285–292
Papaioannou GI, Seip RL, Grey NJ, Katten D, Taylor A, Inzucchi SE, Young LH, Chyun DA, Davey JA, Wackers FJ, Iskandrian AE, Ratner RE, Robinson EC, Carolan S, Engel S, Heller GV (2004) Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics-brachial artery reactivity study). Am J Cardiol 94:294–299
Chambers JC, Obeid OA, Kooner JS (1999) Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects. Arterioscler Thromb Vasc Biol 19:2922–2927
Chenevard R, Hurlimann D, Bechir M, Enseleit F, Spieker L, Hermann M, Riesen W, Gay S, Gay RE, Neidhart M, Michel B, Luscher TF, Noll G, Ruschitzka F (2003) Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation 107:405–409
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Urbina, E.M. (2011). Target Organ Damage Related to Cardiovascular Risk Factors in Youth. In: Berenson, G. (eds) Evolution of Cardio-Metabolic Risk from Birth to Middle Age:. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1451-9_9
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