Abstract
Impaired glucose homeostasis is one of the most common causes of death in the U.S. The progressive global epidemic of obesity makes it a major causal factor for pre-diabetes and type 2 diabetes, which may represent the two categories of impaired glucose regulation. Recognition of the importance of black–white contrast in the prevalence of type 2 diabetes mellitus has stirred up interest in its potential role in the development and progression of diabetes. Accumulating evidence suggests that multiple cardiometabolic risk factors such as insulin resistance/hyperinsulinemia, adiposity, genetic predisposition, low birth weight, prepuberty, inflammation markers including C-reactive protein and adiponectin, chronic kidney dysfunction, and environmental and socio-economic status lead to the black–white divergence in type 2 diabetes. Early prevention and intervention for these risk factors, especially obesity and altered lifestyles involving physical activity and dietary consumption, may help to neutralize the racial disparities seen in the emerging epidemic of diabetes beginning in youth.
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Hoyert DL, Heron MP, Murphy SL, Kung H (2006) Deaths. Final data for 2003. National vital statistics reports, vol 54, No 13. National Center for Health Statistics, Hyattsville
Cowie CC, Rust KF, Byrd-Holt DD, Eberhardt MS, Flegal KM, Engelgau MM, Saydah SH, Williams DE, Geiss LS, Gregg EW (2006) Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999–2002. Diabetes Care 29:1263–1268
Fox CS, Sullivan L, D’Agostino RB Sr, Wilson PW. (2004) Framingham Heart Study. The significant effect of diabetes duration on coronary heart disease mortality: the Framingham Heart Study. Diabetes Care 27:704–708
Osei K, Schuster DP (1994) Ethnic differences in secretion, sensitivity, and hepatic extraction of insulin in black and white Americans. Diabet Med 11:755–62
Zimmet P (1982) Type 2 (non-insulin-dependent) diabetes—an epidemiological overview. Diabetologia 22:399–411
Nguyen QM, Srinivasan SR, Xu JH, Chen W, Berenson GS (2008) Changes in risk variables of metabolic syndrome since childhood in pre-diabetic and type 2 diabetic subjects: the Bogalusa Heart Study. Diabetes Care 31:2044–2049
Richard Kahn (2000) American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care 23:381–389
Svec F, Nastasi K, Hilton C, Bao W, Srinivasan SR, Berenson GS. (1992) Black–white contrasts in insulin levels during pubertal development. The Bogalusa Heart Study. Diabetes 41:313–317
Jiang X, Srinivasan SR, Radhakrishnamurthy B, Dalferes ER, Berenson GS (1996) Racial (black–white) differences in insulin secretion and clearance in adolescents: the Bogalusa Heart Study. Pediatrics 97:357–360
Botero D, Wolfsdorf JI (2005) Diabetes mellitus in children and adolescents. Arch Med Res 36:281–290
Arslanian SA, Saad R, Lewy V, Danadian K, Janosky J (2002) Hyperinsulinemia in African–American children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity. Diabetes 51:3014–3019
Strauss RS, Pollack HA (2001) Epidemic increase in childhood overweight, 1986–1998. JAMA 286:2845–2848
Okosun IS (2001) Racial differences in rates of type 2 diabetes in American women: how much is due to differences in overall adiposity? Ethn Health 6:27–34
Broyles S, Katzmarzyk PT, Srinivasan SR, Chen W, Bouchard C, Freedman DS, Berenson GS (2010) The pediatric obesity epidemic continues unabated in Bogalusa, Louisiana. Pediatrics 125:900–905
Schuster DP, Kien CL, Osei K (1998) Differential impact of obesity on glucose metabolism in black and white American adolescents. Am J Med Sci 316:361–367
Gungor N, Hannon T, Libman I, Bacha F, Arslanian S (2005) Type 2 diabetes mellitus in youth: the complete picture to date. Pediatr Clin North Am 52:1579–1609
Bacha F, Saad R, Gungor N, Janosky J, Arslanian SA (2003) Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab 88:2534–2540
Nguyen QM, Srinivasan SR, Xu JH, Chen W, Berenson GS (2008) Distribution and cardiovascular risk correlates of hemoglobin A(1c) in nondiabetic younger adults: the Bogalusa Heart Study. Metabolism 57:1487–1492
Franks PW, Hanson RL, Knowler WC, Moffett C, Enos G, Infante AM, Krakoff J, Looker HC (2007) Childhood predictors of young-onset type 2 diabetes. Diabetes 56:2964–2972
Srinivasan SR, Myers L, Berenson GS (1999) Temporal association between obesity and hyperinsulinemia in children, adolescents, and young adults: the Bogalusa Heart Study. Metabolism 48:928–934
Srinivasan SR, Myers L, Berenson GS (2002) Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes 51:204–209
Thorens B (2008) Glucose sensing and the pathogenesis of obesity and type 2 diabetes. Int J Obes (Lond) 32(Suppl 6):62–71
Sonnett TE, Levien TL, Gates BJ, Robinson JD, Campbell RK (2010) Diabetes mellitus, inflammation, obesity: proposed treatment pathways for current and future therapies. Ann Pharmacother 44:701–711
Møller N, Jørgensen JO (2009) Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev 30:152–177
Gower BA, Fernández JR, Beasley TM, Shriver MD, Goran MI (2003) Using genetic admixture to explain racial differences in insulin-related phenotypes. Diabetes 52:1047–1051
Carulli L, Rondinella S, Lombardini S, Canedi I, Loria P, Carulli N (2005) Review article: diabetes, genetics and ethnicity. Aliment Pharmacol Ther 22(Suppl 2):16–19
Stocker CJ, Arch JR, Cawthorne MA (2005) Fetal origins of insulin resistance and obesity. Proc Nutr Soc 64:143–151
Paradies YC, Montoya MJ, Fullerton SM (2007) Racialized genetics and the study of complex diseases: the thrifty genotype revisited. Perspect Biol Med 50:203–227
Huang B, Rodriguez BL, Burchfiel CM, Chyou PH, Curb JD, Yano K (1996) Acculturation and prevalence of diabetes among Japanese–American men in Hawaii. Am J Epidemiol 144:674–681
Rodriguez BL, Curb JD, Burchfiel CM, Huang B, Sharp DS, Lu GY, Fujimoto W, Yano K (1996) Impaired glucose tolerance, diabetes, and cardiovascular disease risk factor profiles in the elderly. The Honolulu Heart Program. Diabetes Care 19:587–590
Ellsworth DL, Coady SA, Chen W, Srinivasan SR, Elkasabany A, Gustat J, Boerwinkle E, Berenson GS (2002) Influence of the beta2-adrenergic receptor Arg16Gly polymorphism on longitudinal changes in obesity from childhood through young adulthood in a biracial cohort: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 26:928–937
Nguyen QM, Srinivasan SR, Xu JH, Chen W, Berenson GS (2009) Influence of childhood parental history of type 2 diabetes on the pre-diabetic and diabetic status in adulthood: the Bogalusa Heart Study. Eur J Epidemiol 24:537–539
Lackland DT, Egan BM, Syddall HE, Barker DJ (2002) Associations between birth weight and antihypertensive medication in black and white medicaid recipients. Hypertension 39:179–183
Ventura SJ, Martin JA, Curtin SC, Mathews TJ, Park MM (2000) National vital statistics report. U.S. Department of Health and Human Services, Hyattsville, pp 1–100
Eriksson JG, Forsén TJ (2002) Childhood growth and coronary heart disease in later life. Ann Med 34:157–161
Eriksson JG, Forsén T, Tuomilehto J, Jaddoe VW, Osmond C, Barker DJ (2002) Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals. Diabetologia 45:342–348
Gautier JF, Wilson C, Weyer C, Mott D, Knowler WC, Cavaghan M, Polonsky KS, Bogardus C, Pratley RE (2001) Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes. Diabetes 50:1828–1833
Forsén T, Eriksson J, Tuomilehto J, Reunanen A, Osmond C, Barker D (2000) The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med 133:176–182
Whincup PH, Kaye SJ, Owen CG, Huxley R, Cook DG, Anazawa S, Barrett-Connor E, Bhargava SK, Birgisdottir BE, Carlsson S, de Rooij SR, Dyck RF, Eriksson JG, Falkner B, Fall C, Forsén T, Grill V, Gudnason V, Hulman S, Hyppönen E, Jeffreys M, Lawlor DA, Leon DA, Minami J, Mishra G, Osmond C, Power C, Rich-Edwards JW, Roseboom TJ, Sachdev HS, Syddall H, Thorsdottir I, Vanhala M, Wadsworth M, Yarbrough DE (2008) Birth weight and risk of type 2 diabetes: a systematic review. JAMA 300:2886–2897
Morrison JA, Alfaro MP, Khoury P, Thornton BB, Daniels SR (1996) Determinants of resting energy expenditure in young black girls and young white girls. J Pediatr 129:637–642
Arslanian S, Suprasongsin C (1996) Differences in the in vivo insulin secretion and sensitivity of healthy black versus white adolescents. J Pediatr 129:440–443
Webber LS, Cresanta JL, Croft JB, Srinivasan SR, Berenson GS (1986) Transitions of cardiovascular risk from adolescence to young adulthood—the Bogalusa Heart Study: II. Alterations in anthropometric blood pressure and serum lipoprotein variables. J Chronic Dis 39:91–103
Freedman DS, Dietz WH, Srinivasan SR, Berenson GS (1999) The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 103:1175–1182
Bacha F, Saad R, Gungor N, Arslanian SA (2005) Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African–American children? Pediatr Diabetes 6:100–102
Patel DA, Srinivasan SR, Xu JH, Chen W, Berenson GS (2006) Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Metabolism 55:1551–1557
Toprak D, Toprak A, Chen W, Xu JH, Srinivasan S, Berenson GS (2011) Adiposity in childhood is related to C-reactive protein and adiponectin in young adulthood: from the Bogalusa Heart Study. Obesity (Silver Spring) 19:185–190
Patel DA, Srinivasan SR, Xu JH, Li S, Chen W, Berenson GS. (2006) Distribution and metabolic syndrome correlates of plasma C-reactive protein in biracial (black–white) younger adults: the Bogalusa Heart Study. Metabolism 55:699–705
U.S. Renal Data Systems USRDS 2007 (2010) Annual data report: Atlas of end stage renal disease in the United States. National Institutes of Health, NI-DDK, Bethesda, MD, 2007. Incidence & prevalence. Am J Kidney Dis 55(Suppl 1):S231–S240
Herrera R, Almaguer M, Chipi J, Martínez O, Bacallao J, Rodríguez N, Abreu Mde L, Fariña O, Roche Mdel C (2010) Albuminuria as a marker of kidney and cardio–cerebral vascular damage. Isle of Youth Study (ISYS), Cuba. MEDICC Rev 12:20–26
Chauveau P, Rigalleau V, Aparicio M (2008) Insulin resistance and chronic kidney disease. Nephrol Ther 4:568–574
Bello AK, Nwankwo E, El Nahas AM(2005) Prevention of chronic kidney disease: a global challenge. Kidney Int 98(Suppl):S11–S17
Sarnak MJ, Levey AS (2000) Cardiovascular disease and chronic renal disease: a new paradigm. Am J Kidney Dis 35(4 Suppl 1):S117–S131
de Zeeuw D (2004) Albuminuria, not only a cardiovascular/renal risk marker, but also a target for treatment? Kidney Int 92(Suppl):S2–S6
Muntner P, Arshad A, Morse SA, Patel DA, Manapatra PD, Reisin E, Aguilar EA, Chen W, Srinivasan S, Berenson GS (2009) End-stage renal disease in young black males in a black–white population: longitudinal analysis of the Bogalusa Heart Study. BMC Nephrol 10:40
Naser KA, Gruber A, Thomson GA (2006) The emerging pandemic of obesity and diabetes: are we doing enough to prevent a disaster? Int J Clin Pract 60:1093–1097
Cowie CC, Rust KF, Ford ES, Eberhardt MS, Byrd-Holt DD, Li C, Williams DE, Gregg EW, Bainbridge KE, Saydah SH, Geiss LS (2009) Full accounting of diabetes and pre-diabetes in the U.S. Population in 1988–1994 and 2005–2006. Diabetes Care 32:287–294
Stenvinkel P (2010) Chronic kidney disease: a public health priority and harbinger of premature cardiovascular disease. J Intern Med 268:456–467
Laspa E, Christen A, Efstathiadou Z, Johnston DG, Godsland IF (2007) Long-term changes and variability in diabetes risk factors prior to the development of impaired glucose homeostasis. Diabet Med 24:1269–1278
Klein BE, Klein R, Moss SE, Cruickshanks KJ (1996) Parental history of diabetes in a population-based study. Diabetes Care 19:827–830
Wilson PW, Meigs JB, Sullivan L, Fox CS, Nathan DM, D’Agostino RB Sr (2007) Prediction of incident diabetes mellitus in middle aged adults: the Framingham offspring study. Arch Intern Med 167:1068–1074
LaVeist TA, Thorpe RJ Jr, Galarraga JE, Bower KM, Gary-Webb TL (2009) Environmental and socio-economic factors as contributors to racial disparities in diabetes prevalence. J Gen Intern Med 24:1144–1148
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Nguyen, Q., Srinivasan, S.R., Berenson, G.S. (2011). Black–White Divergence Influencing Impaired Fasting Glucose and Type 2 Diabetes Mellitus. In: Berenson, G. (eds) Evolution of Cardio-Metabolic Risk from Birth to Middle Age:. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1451-9_5
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DOI: https://doi.org/10.1007/978-94-007-1451-9_5
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