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Evolution of Cardio-Metabolic Risk from Birth to Middle Age: pp 35–52Cite as

Evolution of Metabolic Syndrome from Childhood

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Abstract

Metabolic syndrome (MetS), the concurrence of inextricably linked disorders including obesity, insulin resistance, dyslipidemia and hypertension, has gained importance because of its association with subsequent morbidity and mortality from cardiovascular disease. This chapter reviews observations on the MetS in children and adults from the Bogalusa Heart Study, a biracial (black–white) community-based longitudinal study of the early natural history of cardiovascular disease beginning in childhood. The evolution of the definition, the role of obesity in the pathogenesis of the syndrome, tracking from childhood to adulthood and black–white difference in prevalence of the MetS are described. With respect to clustering analysis of the MetS components, conventional and advanced statistical methodologies, including observed to expected ratio, intraclass correlation, factor analysis and path analysis, are explained in detail. Observations from the Bogalusa Heart Study reinforce recommendations to prevent and modulate the development of the MetS during childhood.

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  1. Center for Cardiovascular Health, Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA

    Wei Chen

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  1. , Department of Epidemiology, Tulane University, Canal Street 1440, New Orleans, 70112, Louisiana, USA

    Gerald S. Berenson

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Chen, W. (2011). Evolution of Metabolic Syndrome from Childhood. In: Berenson, G. (eds) Evolution of Cardio-Metabolic Risk from Birth to Middle Age:. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1451-9_4

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