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Antibody Expression and Production pp 143–164Cite as

Production of Antibodies in Plants

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Part of the book series: Cell Engineering ((CEEN,volume 7))

Abstract

Plants are specially suited organisms for production of high amounts of carbon-reduced molecules at low cost. Is it possible to take advantage of this privileged position for the manufacturing of value-added proteins as antibodies? Three decades ago the assembly of functional antibodies in plants was first demonstrated. Since then, many examples of plant-made antibodies in different formats and for different applications have been reported. It was not until improvements in transient expression technologies were introduced in recent years that plant-made antibody yields became similar to those of competing platforms. Transient expression systems are adapting well to the latest market trends of speed and quality, and therefore successful products are expected to reach the market propelled by this technology wave. New developments will probably come from optimized platforms, designed according to synthetic biology standards, to integrate in a single plant chassis a number of traits specifically engineered for recombinant protein production. Platform optimization will include advances on subcellular targeting, transcriptional control, protein degradation, glyco-engineering and downstream processing, all of which are reviewed here, together with other adaptations to the agricultural scale as gene containment or identity preservation.

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Authors and Affiliations

  1. Instituto de Biología Molecular y Celular de Plantas (IBMCP), UPV-CSIC, 46022, Valencia, Spain

    Alejandro Sarrion-Perdigones, Paloma Juarez, Antonio Granell & Diego Orzaez

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  1. Alejandro Sarrion-Perdigones
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  2. Paloma Juarez
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  3. Antonio Granell
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  4. Diego Orzaez
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Correspondence to Diego Orzaez .

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  1. Dept. Chemical & Biochemical, Engineering, University College, Dublin, Belfield, Dublin 4, Ireland

    Mohamed Al-Rubeai

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Sarrion-Perdigones, A., Juarez, P., Granell, A., Orzaez, D. (2011). Production of Antibodies in Plants. In: Al-Rubeai, M. (eds) Antibody Expression and Production. Cell Engineering, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1257-7_7

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