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Integrin-Extracellular Matrix Interactions

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Tumor-Associated Fibroblasts and their Matrix

Part of the book series: The Tumor Microenvironment ((TTME,volume 4))

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Abstract

The extracellular matrix is an essential component of the tumor microenvironment that promotes tumor development and metastasis. Fibroblasts, endothelial cells and other stromal cells deposit extracellular matrix and growth factors that promote the growth and spread of cancer cells. Changes in the composition or architecture of the extracellular matrix within tumors can alter integrin expression and function and promote metastatic progression, angiogenesis and lymphangiogenesis. Since integrins and extracellular matrix molecules provide tumor cells with survival signals, increased blood flow and avenues for metastatic escape, suppression of integrin or extracellular matrix protein expression or function may be useful in the treatment of cancer.

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Authors and Affiliations

  1. Moores UCSD Cancer Center, University of California, San Diego, 3855 Health Sciences Drive #0819, 92093-0819, La Jolla, CA, USA

    Christie J. Avraamides

  2. Department of Medicine, University of California, San Diego, 92093-0819, La Jolla, CA, USA

    Judith A. Varner

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  1. Christie J. Avraamides
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Correspondence to Judith A. Varner .

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  1. Siederstrasse 13, Villingen-Schwenningen, 78054, Germany

    Margareta M. Mueller

  2. Am Pferchelhang 32, Heidelberg, 69118, Germany

    Norbert E. Fusenig

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Avraamides, C.J., Varner, J.A. (2011). Integrin-Extracellular Matrix Interactions. In: Mueller, M., Fusenig, N. (eds) Tumor-Associated Fibroblasts and their Matrix. The Tumor Microenvironment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0659-0_18

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