Abstract
Tumours are highly complex tissues composed of carcinoma cells and a surrounding stroma consisting of various mesenchymal cells and a highly specialised extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which include both fibroblast and myofibroblast cell populations, are major cell types present within the stroma of many different types of cancer. These cells are capable of promoting tumourigenesis through their interactions with carcinoma cells. CAFs and other mesenchymal cells within the tumour microenvironment secrete elevated levels of the pro-angiogenic chemokine, stromal cell-derived factor-1 (SDF-1 ; also known as CXCL12). This chemokine specifically binds to the cell surface receptors CXCR4 and CXCR7 , predominantly expressed on nearby carcinoma cells. Although it is well-demonstrated that activation of the SDF-1 -CXCR4 and SDF-1 -CXCR7 signalling is important for tumour progression, little is known about the functional role of their downstream signalling pathways that promote tumourigenesis. In this chapter, we discuss the potential function of SDF-1 , secreted by the stroma, in providing a niche within the tumour microenvironment. Within this context, we also highlight the important role of stromal fibroblasts in promoting tumourigenesis, invasion and metastasis.
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Shimoda, M., Mellody, K., Orimo, A. (2011). The SDF-1 -Rich Tumour Microenvironment Provides a Niche for Carcinoma Cells. In: Mueller, M., Fusenig, N. (eds) Tumor-Associated Fibroblasts and their Matrix. The Tumor Microenvironment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0659-0_13
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DOI: https://doi.org/10.1007/978-94-007-0659-0_13
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