Abstract
Throughout the course of human history, surgical therapy has remained a viable option for the treatment of certain, well-defined lesions. However, particularly given the technological advancements over the last half-century, the fields of neurosurgery and neurooncology have been able to embrace multimodal forms of therapy, including maximal safe surgical resection, radiotherapy, and both local and systemic chemotherapy, in an effort to improve survival and decrease the odds of developing new post-operative deficits in patients with highly malignant gliomas. Some studies do appear to indicate that extent of resection plays a favorable role in survival of patients with high grade gliomas, although the exact relationship between extent of resection and survival or poor outcomes is not completely defined. Future prospective, randomized trials may need to be developed to assess the effect of multimodal forms of imaging, motor mapping, and combination forms of therapy upon short- and long-term patient outcomes.
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Mukherjee, D., Quinones-Hinojosa, A. (2011). Impact of Extent of Resection on Outcomes in Patients with High-Grade Gliomas. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 2. Tumors of the Central Nervous System, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0618-7_19
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