Abstract
High-grade gliomas (HGG) are the most challenging brain tumors to treat. Even though various sophisticated options exist to treat patients with gliomas, the disease invariably leads to death over months or years. The major obstacles encountered in treating gliomas are in determining the exact location, extent, and metabolic activity of the tumor. Molecular imaging of energy metabolism, amino acid transport, cell proliferation and cell death have been found helpful in identifying the biologically active tumor tissues for therapy. It allows a better understanding of pathology at the molecular level. This ability is especially useful in brain tumors where tissue sampling in vivo is associated with significant risks. Positron emission tomography (PET) is one of the most prominent molecular imaging modalities utilized for imaging pathophysiology of tumors at an early stage. In this chapter, the applicability of PET in assessing the biologically active tumor volumes in high-grade glioma patients for radiation therapy treatment planning and therapy monitoring will be reviewed. We will focus on the concept of biological target volume (BTV) and associated methods of image segmentation available for delineating tumor volumes in connection with their applicability in high-grade gliomas.
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Zaidi, H., Senthamizhchelvan, S. (2011). Assessment of Biological Target Volume Using Positron Emission Tomography in High-Grade Glioma Patients. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 2. Tumors of the Central Nervous System, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0618-7_15
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